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a b b a Shean J. Aujla , Kristie R. Ross , James F. Chmiel and Fernando Holguin Division of Pulmonary Medicine, Allergy and Purpose of review Immunology, Children’s Hospital of Pittsburgh of The review discusses what is known regarding airway molecular phenotypes in pediatric UPMC, Pittsburgh, Pennsylvania and Division of Pediatric Pulmonology, Case Western Reserve asthma, specifically biomarkers that have been studied and their relation to the various University School of Medicine, Case Medical Center/ clinical phenotypes of asthma. Rainbow Babies and Children’s Hospital, Cleveland, Ohio, USA Recent findings Pediatric asthma is a complex and heterogeneous disease that consists of several Correspondence to Shean J. Aujla, Assistant Professor of Pediatrics, Division of Pulmonary Medicine, Allergy clinical phenotypes. There have been numerous studies investigating inflammatory and Immunology, Children’s Hospital of Pittsburgh of markers that would increase our understanding of the underlying pathogenesis of UPMC, Pittsburgh, PA 15224, USA Tel: +1 412 692 8112; fax: +1 412 692 6645; asthma as well as facilitate the discovery of therapies for these patients. Some of these e-mail: shean.aujla@chp.edu biomarkers, such as exhaled nitric oxide, exhaled breath condensate, urine leukotriene Current Opinion in Allergy and Clinical E4 and induced sputum are less invasive
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Apr 1, 2011
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