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Adverse reactions to drugs used to treat alcoholism

Adverse reactions to drugs used to treat alcoholism December 2007 No. 247 Founded in 1966 by Professor D M Davies, FRCP, FRCP Ed ISSN 0044–6394 Acute phase Adverse reactions to drugs used to Benzodiazepines treat alcoholism Benzodiazepines (primarily diazepam and chlordiazepoxide) have been Byron Theron & Saket Singhal shown to improve psychomotor agita- Department of Gastroenterology, Sandwell General Hospital, Lyndon, West Bromwich, UK tion associated with acute alcohol Correspondence to Byron Theron, MB, ChB, MRCP, Department of Gastroenterology, withdrawal safely and effectively. Sandwell General Hospital, Lyndon, West Bromwich, B71 4HJ, UK These drugs are generally considered well tolerated in a controlled environ- ment. The main concerns relate to Summary the risk of oversedation and respiratory The armamentarium of drugs used in the treatment of alcohol abuse has grown depression, particularly in patients with with newer and novel therapies introduced to improve compliance and adverse liver or lung disease and in the elderly. effect profiles. There is now a range of treatments particularly aimed at reducing These effects can be reversed by the use craving and improving abstinence rates, including opioid antagonists (both long- of flumazenil. acting and short-acting) and g-aminobutyric-acid receptor analogues, which The use of these drugs should ideally have a good evidence base and are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Adverse Drug Reaction Bulletin Wolters Kluwer Health

Adverse reactions to drugs used to treat alcoholism

Theron, Byron; Singhal, Saket
Adverse Drug Reaction Bulletin , Volume &NA; (247) – Dec 1, 2007
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References (44)

Copyright
© 2007 Lippincott Williams & Wilkins, Inc.
ISSN
0044-6394
eISSN
2159-7774
DOI
10.1097/FAD.0b013e328300788f
Publisher site
See Article on Publisher Site

Abstract

December 2007 No. 247 Founded in 1966 by Professor D M Davies, FRCP, FRCP Ed ISSN 0044–6394 Acute phase Adverse reactions to drugs used to Benzodiazepines treat alcoholism Benzodiazepines (primarily diazepam and chlordiazepoxide) have been Byron Theron & Saket Singhal shown to improve psychomotor agita- Department of Gastroenterology, Sandwell General Hospital, Lyndon, West Bromwich, UK tion associated with acute alcohol Correspondence to Byron Theron, MB, ChB, MRCP, Department of Gastroenterology, withdrawal safely and effectively. Sandwell General Hospital, Lyndon, West Bromwich, B71 4HJ, UK These drugs are generally considered well tolerated in a controlled environ- ment. The main concerns relate to Summary the risk of oversedation and respiratory The armamentarium of drugs used in the treatment of alcohol abuse has grown depression, particularly in patients with with newer and novel therapies introduced to improve compliance and adverse liver or lung disease and in the elderly. effect profiles. There is now a range of treatments particularly aimed at reducing These effects can be reversed by the use craving and improving abstinence rates, including opioid antagonists (both long- of flumazenil. acting and short-acting) and g-aminobutyric-acid receptor analogues, which The use of these drugs should ideally have a good evidence base and are

Journal

Adverse Drug Reaction Bulletin – Wolters Kluwer Health

Published: Dec 1, 2007

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