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Adverse drug reactions: five historical scandals

Adverse drug reactions: five historical scandals Downloaded from http://journals.lww.com/adversedrugreactbull by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9l2nY+zyylnl33NGMK6MRsx on 10/23/2020 October 2020 No. 324 Founded in 1966 by Professor D M Davies, FRCP, FRCP Ed ISSN 0044–6394 Adverse drug reactions: five historical Elixir Sulfanilamide scandals Sulfanilamide is a sulfonamide antibiotic. The compound was initially synthesized in a,b a 1908, and in January 1937 evidence Henrik Horwitz , Ditte Resendal Gotfredsen & emerged that it was effective in the treatment Thea Christoffersen 8 of streptococcal infections (Fig. 2). The Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital and same year S.E. Massengill Company started Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark manufacturing sulfanilamide capsules and Correspondence to Henrik Horwitz, MD, PhD, associate professor, Department of Clinical tablets, but soon realized that there was a Pharmacology, Bispebjerg and Frederiksberg Hospital, Bispebjerg Bakke 23, 2400 8,9 demand for a liquid formulation. The Copenhagen, Denmark. Tel.: +4529464288. company’s chief chemist discovered that E-mail: henrik_horwitz@hotmail.com and henrik.horwitz@regionh.dk the drug could be dissolved in diethylene glycol, and in September 1937 the so-called Elixir Sulfanilamide, consisting of 72% diethylene glycol and 10% sulfanilamide, Summary 8,9 reached the market. Unfortunately, It is estimated that eight percentage of all acute medical admissions are due diethylene glycol is one of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Adverse Drug Reaction Bulletin Wolters Kluwer Health

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
0044-6394
eISSN
2159-7774
DOI
10.1097/FAD.0000000000000050
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/adversedrugreactbull by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9l2nY+zyylnl33NGMK6MRsx on 10/23/2020 October 2020 No. 324 Founded in 1966 by Professor D M Davies, FRCP, FRCP Ed ISSN 0044–6394 Adverse drug reactions: five historical Elixir Sulfanilamide scandals Sulfanilamide is a sulfonamide antibiotic. The compound was initially synthesized in a,b a 1908, and in January 1937 evidence Henrik Horwitz , Ditte Resendal Gotfredsen & emerged that it was effective in the treatment Thea Christoffersen 8 of streptococcal infections (Fig. 2). The Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital and same year S.E. Massengill Company started Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark manufacturing sulfanilamide capsules and Correspondence to Henrik Horwitz, MD, PhD, associate professor, Department of Clinical tablets, but soon realized that there was a Pharmacology, Bispebjerg and Frederiksberg Hospital, Bispebjerg Bakke 23, 2400 8,9 demand for a liquid formulation. The Copenhagen, Denmark. Tel.: +4529464288. company’s chief chemist discovered that E-mail: henrik_horwitz@hotmail.com and henrik.horwitz@regionh.dk the drug could be dissolved in diethylene glycol, and in September 1937 the so-called Elixir Sulfanilamide, consisting of 72% diethylene glycol and 10% sulfanilamide, Summary 8,9 reached the market. Unfortunately, It is estimated that eight percentage of all acute medical admissions are due diethylene glycol is one of

Journal

Adverse Drug Reaction BulletinWolters Kluwer Health

Published: Oct 1, 2020

References