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Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy

Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving... REVIEW URRENT Advances in detection and monitoring of plasma PINION viremia in HIV-infected individuals receiving antiretroviral therapy a,b Sarah Palmer Purpose of review This review will describe advances in detection and results of monitoring persistent viremia in patients on long-term suppressive therapy. In addition, the review explores the usefulness of these methods in determining the effectiveness of new HIV-1 eradication strategies in purging persistent HIV-1 reservoirs. Recent findings Quantification of plasma HIV-1 RNA levels remains essential for determining the success of combination antiretroviral therapy (cART) in treated patients. Recently, several new platforms with improved sensitivity for quantifying HIV-1 RNA have been developed and the application of these assays has revealed that low- level viremia persists in patients on suppressive therapy. In addition, new technological advances such as digital PCR have been proposed to increase the sensitivity of measuring and characterizing persistent HIV-1 viremia. The application of these assays will be important in determining the effectiveness of future HIV-1 eradication strategies. Summary The level of HIV-1 RNA in patient plasma remains an important marker for determining the success of cART. New sensitive assays have found that HIV-1 persists in the plasma of patients on suppressive therapy that may have implications http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy

Palmer, Sarah
Current Opinion in HIV and Aids , Volume 8 (2) – Mar 1, 2013
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Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e32835d80af
pmid
23314906
Publisher site
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Abstract

REVIEW URRENT Advances in detection and monitoring of plasma PINION viremia in HIV-infected individuals receiving antiretroviral therapy a,b Sarah Palmer Purpose of review This review will describe advances in detection and results of monitoring persistent viremia in patients on long-term suppressive therapy. In addition, the review explores the usefulness of these methods in determining the effectiveness of new HIV-1 eradication strategies in purging persistent HIV-1 reservoirs. Recent findings Quantification of plasma HIV-1 RNA levels remains essential for determining the success of combination antiretroviral therapy (cART) in treated patients. Recently, several new platforms with improved sensitivity for quantifying HIV-1 RNA have been developed and the application of these assays has revealed that low- level viremia persists in patients on suppressive therapy. In addition, new technological advances such as digital PCR have been proposed to increase the sensitivity of measuring and characterizing persistent HIV-1 viremia. The application of these assays will be important in determining the effectiveness of future HIV-1 eradication strategies. Summary The level of HIV-1 RNA in patient plasma remains an important marker for determining the success of cART. New sensitive assays have found that HIV-1 persists in the plasma of patients on suppressive therapy that may have implications

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Mar 1, 2013

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