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Adrenocortical Carcinoma A Comprehensive Immunohistochemical Study of 40 Cases

Adrenocortical Carcinoma A Comprehensive Immunohistochemical Study of 40 Cases RESEARCH ARTICLE Adrenocortical Carcinoma: A Comprehensive Immunohistochemical Study of 40 Cases Annikka Weissferdt, MD, FRCPath,* Alexandria Phan, MD,w Saul Suster, MD,z and Cesar A. Moran, MD* from the cells of the adrenal cortex, specialized steroido- Abstract: Adrenocortical carcinomas (ACC) are uncommon tu- genic cells that produce glucocorticoids, mineralocorticoids, mors of the adrenal cortex that are known to follow an aggressive and androgens. Tumorigenesis may lead to abnormal clinical course. The distinction of these tumors from other neo- hormone function and result in excess production of steroid plasms may sometimes prove difficult due to overlapping clinical, hormones that may clinically manifest as Cushing morphologic, and even immunophenotypical features. To this end, syndrome, Conn syndrome, virilization, or feminization. we performed a comprehensive immunohistochemical analysis using However, a proportion of ACC may be nonfunctional and traditional and novel markers in 40 cases of ACC. An im- patients present with nonspecific symptoms such as ab- munohistochemical panel consisting of 10 traditional and novel dominal pain or fatigue. Because of morphologic variability antibodies was applied to whole tissue sections of ACC including and histologic overlap, the separation of ACC from other high-molecular weight cytokeratin (HMWCK), low-molecular adrenal or retroperitoneal neoplasms may be difficult, es- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Adrenocortical Carcinoma A Comprehensive Immunohistochemical Study of 40 Cases

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31828a96cf
pmid
23531850
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Adrenocortical Carcinoma: A Comprehensive Immunohistochemical Study of 40 Cases Annikka Weissferdt, MD, FRCPath,* Alexandria Phan, MD,w Saul Suster, MD,z and Cesar A. Moran, MD* from the cells of the adrenal cortex, specialized steroido- Abstract: Adrenocortical carcinomas (ACC) are uncommon tu- genic cells that produce glucocorticoids, mineralocorticoids, mors of the adrenal cortex that are known to follow an aggressive and androgens. Tumorigenesis may lead to abnormal clinical course. The distinction of these tumors from other neo- hormone function and result in excess production of steroid plasms may sometimes prove difficult due to overlapping clinical, hormones that may clinically manifest as Cushing morphologic, and even immunophenotypical features. To this end, syndrome, Conn syndrome, virilization, or feminization. we performed a comprehensive immunohistochemical analysis using However, a proportion of ACC may be nonfunctional and traditional and novel markers in 40 cases of ACC. An im- patients present with nonspecific symptoms such as ab- munohistochemical panel consisting of 10 traditional and novel dominal pain or fatigue. Because of morphologic variability antibodies was applied to whole tissue sections of ACC including and histologic overlap, the separation of ACC from other high-molecular weight cytokeratin (HMWCK), low-molecular adrenal or retroperitoneal neoplasms may be difficult, es-

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2014

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