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Clinical study relating cytokine and metabolic profiles in the context of HIV treatment-associated lipodystrophy, from a productive and thoughtful research group
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Very recent report of an important clinical trial, comparing abacavir versus stavudine treatment (in protease inhibitor-naïve patients) with lipodystrophy outcomes as prominent study endpoints
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Adipose tissue inflammation and altered adipokine and cytokine production in antiretroviral therapy-associated lipodystrophy Emma Hammond and David Nolan Purpose of review Introduction Adipose tissue pathology plays a central role in An association between HIV therapy and the develop- lipodystrophy. This review discusses the mechanisms by ment of a novel form of lipodystrophy was originally which adipose tissue responses to specific antiretroviral described in a number of publications in 1997 and 1998, therapy determine clinical outcomes, and key recent data in which it was observed that HIV-infected patients are examined that can inform the successful avoidance or receiving combination antiretroviral therapy (ART) management of such toxicities. regimens had a markedly increased risk of pathological Recent findings subcutaneous fat loss (hereafter termed lipoatrophy), Changes in body composition and hyperlipidaemia that and components of the metabolic syndrome including occur with the use of certain thymidine analogues and visceral fat gain, mixed hyperlipidaemia and insulin protease inhibitors are accompanied by profound resistance (reviewed in [1,2]). Subsequent clinical and alterations in adipose tissue. Drug toxicity in adipocytes basic science research has established that the diagnostic affects the homeostatic regulation of adipocytokines term ‘lipodystrophy syndrome’ that was applied to these secreted from adipose tissue that
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Jul 1, 2007
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