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Downloaded from http://journals.lww.com/americantherapeutics by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/03/2020 American Journal of Therapeutics 0, 1–3 (2020) Acute Kidney Injury in Patients Using Amikacin in Intensive Care Unit—A Paired Case–Control Study With Meropenem To the Editor: was predefined in 0.2, and we used a ratio of 1:1 to In the past decade, polymyxin B and colistin have optimize balance and precision. been the most important options for the treatment of Bivariate analysis was performed separately for 1 2 carbapenem-resistant Enterobacteriaceae infections. each variable. P values were calculated using the x However, the pharmacokinetic profile and the high test or Fisher exact test for categorical variables and nephrotoxicity are the main limitations of polymyx- Student t test for continuous variables. The multivari- 2,3 ins. Amikacin has been an option in some hospitals able model was performed with the intent to identify for the treatment of carbapenem-resistant bacteria. independent risk factors apart from our main interest New studies evaluating amikacin dose in critical pa- in this study (amikacin vs. meropenem). All tests tients have been recently published. The challenge is were 2-tailed, and a P value #0.05 was considered that some physicians are reluctant to prescribe high significant. Statistical analyses were performed using doses
American Journal of Therapeutics – Wolters Kluwer Health
Published: Jan 1, 2020
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