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Acute Effects of Transluminal Angioplasty in Three Experimental Models of Atherosclerosis

Acute Effects of Transluminal Angioplasty in Three Experimental Models of Atherosclerosis Transluminal angioplasty has shown promise as a nonoperative treatment of atherosclerotic obstruction. Despite its Increasing clinical use and potential Importance, little Is known of its mechanism and acute effects. To evaluate transluminal angioplasty, three rabbit models of experimental atherosclerosis were developed: Group 1 (n = 20) = high cholesterol diet plus balloon de-endothellalization; Group 2A (n = 12) = high cholesterol diet plus an Indwelling catheter; Group 2B (n = 10) = normal diet plus an indwelling catheter. After 6 weeks or 8 weeks, distinct angiographlc and pathological lesions In the iliac artery were evident in all groups. Group 1 showed predominant foam cell lesions, while Group 2 showed eccentric mixed fibrous and foam cell or only fibrous lesions. Significant anglographic stenosis was present in 78% of the animals. Angioplasty of the highest grade lilac stenosis resulted In at least a 20% reduction In luminal diameter narrowing In 26 of 37 animals (70%). Hlstopathologlcal examination 1 day following angloplasty In 17 animals showed two patterns. In Group 1 animals, neointimal fracture and dissection were evident, while in Group 2 animals thinning and stretching of the nonatherosclerotic portion of the vessel walls could be demonstrated. This study demonstrates that the New Zealand rabbit can be used to produce a spectrum of morphologically distinct atherosclerotic lesions that lend themselves to the study of transluminal angloplasty. The immediate consequences of angloplasty, which appear to depend upon the underlying hlstopathology and widening of the narrowed lumen, are frequently concurrent with intlmal fracture, dissection, or thinning of the nonatherosclerotic portion of the vessel wall. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Acute Effects of Transluminal Angioplasty in Three Experimental Models of Atherosclerosis

Arteriosclerosis , Volume 2 (2) – Mar 1, 1982

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Copyright
© 1982 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Transluminal angioplasty has shown promise as a nonoperative treatment of atherosclerotic obstruction. Despite its Increasing clinical use and potential Importance, little Is known of its mechanism and acute effects. To evaluate transluminal angioplasty, three rabbit models of experimental atherosclerosis were developed: Group 1 (n = 20) = high cholesterol diet plus balloon de-endothellalization; Group 2A (n = 12) = high cholesterol diet plus an Indwelling catheter; Group 2B (n = 10) = normal diet plus an indwelling catheter. After 6 weeks or 8 weeks, distinct angiographlc and pathological lesions In the iliac artery were evident in all groups. Group 1 showed predominant foam cell lesions, while Group 2 showed eccentric mixed fibrous and foam cell or only fibrous lesions. Significant anglographic stenosis was present in 78% of the animals. Angioplasty of the highest grade lilac stenosis resulted In at least a 20% reduction In luminal diameter narrowing In 26 of 37 animals (70%). Hlstopathologlcal examination 1 day following angloplasty In 17 animals showed two patterns. In Group 1 animals, neointimal fracture and dissection were evident, while in Group 2 animals thinning and stretching of the nonatherosclerotic portion of the vessel walls could be demonstrated. This study demonstrates that the New Zealand rabbit can be used to produce a spectrum of morphologically distinct atherosclerotic lesions that lend themselves to the study of transluminal angloplasty. The immediate consequences of angloplasty, which appear to depend upon the underlying hlstopathology and widening of the narrowed lumen, are frequently concurrent with intlmal fracture, dissection, or thinning of the nonatherosclerotic portion of the vessel wall.

Journal

ArteriosclerosisWolters Kluwer Health

Published: Mar 1, 1982

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