Abnormal Neural Activity in Children With Diffuse Intrinsic Pontine Glioma Had Manifested Deficit in Behavioral Inhibition: A Resting-State Functional MRI Study
Abnormal Neural Activity in Children With Diffuse Intrinsic Pontine Glioma Had Manifested Deficit...
Cheng, Xu; Gao, Pei-Yi
2019-01-01 00:00:00
Purpose
The purpose of this study was to investigate whether alterations of regional neural function in children with diffuse intrinsic pontine glioma (DIPG) had manifested deficit in behavioral inhibition using resting-state functional MRI (rs-fMRI).
Methods
There were 17 participants with DIPG who took part in the study. Eight children were with deficit in behavioral inhibition, whereas the other 9 children did not obtain deficit in behavioral inhibition. Five healthy children with age, sex, and education matched to the study group also participated as the control group. These 3 groups underwent rs-fMRI, and the results were then converted to amplitude of low-frequency fluctuation (ALFF) data. Amplitude of low-frequency fluctuation data were further analyzed by single-factor analysis of variance comparing among 3 groups based on the whole brain levels. Amplitude of low-frequency fluctuation results were subjected to t test of voxel-wised comparison to derive the rs-fMRI brain function differences between the 2 DIPG groups. The Pearson correlation between ALFF values of abnormal regions found in 3 groups and the scores obtained according to the Child Behavior Checklist were analyzed.
Results
The 3 groups had shown significant differences in terms of the ALFF results, with the ALFF increased in several brain regions (P < 0.05, corrected with AlphaSim, clusters >59 voxels), which include left supramarginal gyrus, left dorsolateral superior frontal gyrus, right precentral gyrus, and right middle frontal gyrus. Participants with deficit in behavioral inhibition had shown significant differences (ALFF decreased) in several brain regions, including left dorsolateral superior frontal gyrus and right fusiform gyrus (P < 0.05, corrected with AlphaSim, clusters >123 voxels), whereas other brain regions had shown ALFF increased, including left supramarginal gyrus, left middle frontal gyrus, and right medial superior frontal gyrus (P < 0.05, corrected with AlphaSim, clusters >123 voxels). There was no significant correlation between ALFF values and Child Behavior Checklist scores (P > 0.05).
Conclusions
These findings of focal spontaneous hyperfunction and hypofunction, which correlate with deficit in behavioral inhibition processing, and the abnormal brain regions are considered to be inefficient (in regions of the brain that may relate to compensatory brain and behavioral functioning, and it may be that the brain region needs to exert extra energy to perform a task to the same degree as the control group) or inability (inability in a certain region, or underpowered), pointing to a pathophysiologic process in executive dysfunction.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngJournal of Computer Assisted TomographyWolters Kluwer Healthhttp://www.deepdyve.com/lp/wolters-kluwer-health/abnormal-neural-activity-in-children-with-diffuse-intrinsic-pontine-0i8Ia715tG
Abnormal Neural Activity in Children With Diffuse Intrinsic Pontine Glioma Had Manifested Deficit in Behavioral Inhibition: A Resting-State Functional MRI Study
Purpose
The purpose of this study was to investigate whether alterations of regional neural function in children with diffuse intrinsic pontine glioma (DIPG) had manifested deficit in behavioral inhibition using resting-state functional MRI (rs-fMRI).
Methods
There were 17 participants with DIPG who took part in the study. Eight children were with deficit in behavioral inhibition, whereas the other 9 children did not obtain deficit in behavioral inhibition. Five healthy children with age, sex, and education matched to the study group also participated as the control group. These 3 groups underwent rs-fMRI, and the results were then converted to amplitude of low-frequency fluctuation (ALFF) data. Amplitude of low-frequency fluctuation data were further analyzed by single-factor analysis of variance comparing among 3 groups based on the whole brain levels. Amplitude of low-frequency fluctuation results were subjected to t test of voxel-wised comparison to derive the rs-fMRI brain function differences between the 2 DIPG groups. The Pearson correlation between ALFF values of abnormal regions found in 3 groups and the scores obtained according to the Child Behavior Checklist were analyzed.
Results
The 3 groups had shown significant differences in terms of the ALFF results, with the ALFF increased in several brain regions (P < 0.05, corrected with AlphaSim, clusters >59 voxels), which include left supramarginal gyrus, left dorsolateral superior frontal gyrus, right precentral gyrus, and right middle frontal gyrus. Participants with deficit in behavioral inhibition had shown significant differences (ALFF decreased) in several brain regions, including left dorsolateral superior frontal gyrus and right fusiform gyrus (P < 0.05, corrected with AlphaSim, clusters >123 voxels), whereas other brain regions had shown ALFF increased, including left supramarginal gyrus, left middle frontal gyrus, and right medial superior frontal gyrus (P < 0.05, corrected with AlphaSim, clusters >123 voxels). There was no significant correlation between ALFF values and Child Behavior Checklist scores (P > 0.05).
Conclusions
These findings of focal spontaneous hyperfunction and hypofunction, which correlate with deficit in behavioral inhibition processing, and the abnormal brain regions are considered to be inefficient (in regions of the brain that may relate to compensatory brain and behavioral functioning, and it may be that the brain region needs to exert extra energy to perform a task to the same degree as the control group) or inability (inability in a certain region, or underpowered), pointing to a pathophysiologic process in executive dysfunction.
Journal
Journal of Computer Assisted Tomography
– Wolters Kluwer Health
Published: Jan 1, 2019
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References
Brainstem tumors: where are we today?
Recinos, PF; Sciubba, DM; Jallo, GI
Intrinsic brainstem tumors in childhood: surgical indications
Epstein, F; Wisoff, JH
Neuropsychological theory and findings in ADHD: the state of the field and salient challenges for the coming decade
Nigg, JT
Linkages between attention and executive functions
Barkley, RA; Lyon, GR; Krasnegor, NA
Executive functions and developmental psychopathology
Pennington, BE; Ozonoff, S
Not all executive functions are related to intelligence
Friedman, NP; Miyake, A; Corley, RP
Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications
Sonuga-Barke, EJ; Sergeant, JA; Nigg, J
Development of cognitive inhibition
Harnishfeger, K; Dempster, F; Brainerd, C
Inhibition and the right inferior frontal cortex
Aron, AR; Robbins, TW; Poldrack, RA
Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder
Castellanos, FX; Lee, PP; Sharp, W
Magnetic resonance imaging correlates of attention-deficit/hyperactivity disorder in children
Hill, DE; Yeo, RA; Campbell, RA
Regional cerebral blood flow in children with attention deficit hyperactivity disorder: comparison before and after methylphenidate treatment
Lee, JS; Kim, BN; Kang, E
Effects of methylphenidate discontinuation on cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorder
Langleben, DD; Acton, PD; Austin, G
Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI
Rubia, K; Overmeyer, S; Taylor, E
Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study
Vaidya, CJ; Austin, G; Kirkorian, G
Is there evidence for neural compensation in attention deficit hyperactivity disorder? A review of the functional neuroimaging literature
Fassbender, C; Schweitzer, JB
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, MD; Raichle, ME
Functional connectivity in the motor cortex of resting human brain using echo-planar MRI
Biswal, B; Yetkin, FZ; Haughton, VM
Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
Zang, YF; He, Y; Zhu, CZ
Spatial patterns of intrinsic brain activity in mild cognitive impairment and Alzheimer's disease: a resting-state functional MRI study
Wang, Z; Yan, C; Zhao, C
Large-scale brain systems in ADHD: beyond the prefrontal-striatal model
Castellanos, FX; Proal, E
Quantitative brain magnetic resonance imaging in attention deficit hyperactivity disorder
Castellanos, FX; Giedd, JN; Marsh, WL
Cingulate, frontal and parietal cortical dysfunction in attention-deficit/hyperactivity disorder
Bush, G
Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects
Frodl, T; Skokauskas, N
Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD
Barkley, RA
Neuronal mechanisms of executive control by the prefrontal cortex
Funahashi, S
Relevance of the cerebellar hemispheres for executive functions
Karatekin, C; Lazareff, JA; Asamow, RF
How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder?
Sergeant, JA; Geurts, H; Oosterlaan, J
Structural brain imaging of attention-deficit/hyperactivity disorder
Seidman, L; Valera, E; Makris, N
Motor deficits correlate with resting state motor network connectivity in patients with brain tumours
Otten, ML; Mikell, CB; Youngerman, BE
Mapping numerical processing, reading, and executive functions in the developing brain: an fMRI meta-analysis on 52 studies including 842 children
Houdé, O; Rossi, S; Lubin, A
Reduced neuro-integration from the dorsolateral prefrontal cortex to the whole brain and executive dysfunction in schizophrenia patients and their relatives
Su, TW; Lan, TH; Hsu, TW
Spatial and temporal relationships of electrocorticographic alpha and gamma activity during auditory processing
Potes, C; Brunner, P; Gunduz, A
Vulnerability of the frontal and parietal regions in hypertensive patients during working memory task
Li, X; Wang, W; Wang, A
Fronto-cerebellar fiber tractography in pediatric patients following posterior fossa tumor surgery
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