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Abdominal Aortic Aneurysm Growth Predicted by Uptake of Ultrasmall Superparamagnetic Particles of Iron Oxide A Pilot Study Jennifer M.J. Richards, MD; Scott I. Semple, PhD; Thomas J. MacGillivray, PhD; Calum Gray, PhD; Jeremy P. Langrish, MD; Michelle Williams, MD; Marc Dweck, MD; William Wallace, MD; Graham McKillop, MD; Roderick T.A. Chalmers, MD; O. James Garden, MD; David E. Newby, MD Background—Abdominal aortic aneurysms are a major cause of death. Prediction of aneurysm expansion and rupture is challenging and currently relies on the simple measure of aneurysm diameter. Using MRI, we aimed to assess whether areas of cellular inflammation correlated with the rate of abdominal aortic aneurysm expansion. Methods and Results—Stable patients (n29; 27 male; age, 705 years) with asymptomatic abdominal aortic aneurysms (4.0 to 6.6 cm) were recruited from a surveillance program and imaged using a 3-T MRI scanner before and 24 to 36 hours after administration of ultrasmall superparamagnetic particles of iron oxide (USPIO). The change in T2* value on T2*-weighted imaging was used to detect accumulation of USPIO within the abdominal aortic aneurysm. Histological examination of aneurysm tissue confirmed colocalization and uptake of USPIO in areas with macrophage infiltration. Patients with distinct mural uptake of USPIO had
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: May 1, 2011
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