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A structural basis for food allergy: the role of cross-reactivity a b b Rana S. Bonds , Terumi Midoro-Horiuti and Randall Goldblum Division of Allergy, Pulmonary, Immunology, Critical Purpose of review Care and Sleep, University of Texas Medical Branch, Immunologic cross-reactivity, which is important in many aspects of host defense and Galveston, Texas, USA and Child Health Research Center, University of Texas Medical Branch, Galveston, immune-mediated diseases, is a prominent feature of allergic disorders. The goal of this Texas, USA article is to define allergenic cross-reactivity and its role in food allergy, review current Correspondence to Rana S. Bonds, University of Texas understanding of mechanisms of cross-reactivity, and consider how advances in our Medical Branch, 301 University Blvd., Route 0561, ability to predict cross-reactivity can impact diagnosis and treatment of food allergy. Galveston, TX 77555, USA Tel: +1 409 772 3410; fax: +1 409 772 9532; Recent findings e-mail: rsbonds@utmb.edu Recent evidence suggests that specific T cells, in addition to IgE, developed in response to inhaled allergens can cross-react with related food allergens, leading to Current Opinion in Allergy and Clinical distinct clinical reactions. Several new cross-reactivities have been identified, including Immunology 2008, 8:82–86 food–food, pollen–food, and latex–venom associations.
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Feb 1, 2008
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