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A Review on Color Normalization and Color Deconvolution Methods in Histopathology

A Review on Color Normalization and Color Deconvolution Methods in Histopathology REVIEW ARTICLE A Review on Color Normalization and Color Deconvolution Methods in Histopathology Devrim Onder, PhD, Selen Zengin, MD, and Sulen Sarioglu, MD The computerized algorithms produced excellent Abstract: The histopathologists get the benefits of wide range results for excellent or suitable images, but this is not the of colored dyes to have much useful information about the le- case for all images that are part of the daily practice of sions and the tissue compositions. Despite its advantages, the 4 the pathologists. The performance of image analysis staining process comes up with quite complex variations in methods again depend upon the quality of the final staining concentrations and correlations, tissue fixation types, stained tissue section similar to the work of a histo- and fixation time periods. Together with the improvements in pathologist. The properties of the images which are computing power and with the development of novel image driven by the influence of many factors, has important analysis methods, these imperfections have led to the emerging effect on achieving successful computerized image anal- of several color normalization algorithms. This article is a re- ysis results. These factors include the time period and the view of the currently available http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

A Review on Color Normalization and Color Deconvolution Methods in Histopathology

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000003
pmid
24897076
Publisher site
See Article on Publisher Site

Abstract

REVIEW ARTICLE A Review on Color Normalization and Color Deconvolution Methods in Histopathology Devrim Onder, PhD, Selen Zengin, MD, and Sulen Sarioglu, MD The computerized algorithms produced excellent Abstract: The histopathologists get the benefits of wide range results for excellent or suitable images, but this is not the of colored dyes to have much useful information about the le- case for all images that are part of the daily practice of sions and the tissue compositions. Despite its advantages, the 4 the pathologists. The performance of image analysis staining process comes up with quite complex variations in methods again depend upon the quality of the final staining concentrations and correlations, tissue fixation types, stained tissue section similar to the work of a histo- and fixation time periods. Together with the improvements in pathologist. The properties of the images which are computing power and with the development of novel image driven by the influence of many factors, has important analysis methods, these imperfections have led to the emerging effect on achieving successful computerized image anal- of several color normalization algorithms. This article is a re- ysis results. These factors include the time period and the view of the currently available

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Nov 1, 2014

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