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A Limited Immunohistochemical Panel Helps Differentiate Small Cell Epithelial Malignancies of the Sinonasal Cavity and Nasopharynx

A Limited Immunohistochemical Panel Helps Differentiate Small Cell Epithelial Malignancies of the... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE A Limited Immunohistochemical Panel Helps Differentiate Small Cell Epithelial Malignancies of the Sinonasal Cavity and Nasopharynx Jennifer Chapman-Fredricks, MD, Merce Jorda, MD, PhD, and Carmen Gomez-Fernandez, MD (Appl Immunohistochem Mol Morphol 2009;17:207–210) Background: Distinguishing small cell epithelial malignancies of the sinonasal cavity and nasopharynx is difficult due to overlapping morphologic characteristics, particularly in small ancers of the head and neck account for only 3.2% of biopsies. This distinction is important, however, because of the Call malignancies diagnosed in the United States and inherent differences in biology, natural history, prognosis, and only 3.6% of these occur in the sinonasal tract, making treatment among these neoplasms. The aim of this study is to sinonasal malignancies exceedingly rare. In addition to identify a limited immunohistochemical panel that may help to the relatively common squamous cell carcinoma, there are differentiate these morphologically similar small cell epithelial many other clinically aggressive high-grade malignant malignancies. neoplasms that can arise in this complex anatomic region. Many of these high-grade tumors fall under the general Design: We reviewed 37 cases of histologically similar small cell category of small cell malignant neoplasms. epithelial malignancies of the sinonasal cavity and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

A Limited Immunohistochemical Panel Helps Differentiate Small Cell Epithelial Malignancies of the Sinonasal Cavity and Nasopharynx

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Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31818fc85c
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE A Limited Immunohistochemical Panel Helps Differentiate Small Cell Epithelial Malignancies of the Sinonasal Cavity and Nasopharynx Jennifer Chapman-Fredricks, MD, Merce Jorda, MD, PhD, and Carmen Gomez-Fernandez, MD (Appl Immunohistochem Mol Morphol 2009;17:207–210) Background: Distinguishing small cell epithelial malignancies of the sinonasal cavity and nasopharynx is difficult due to overlapping morphologic characteristics, particularly in small ancers of the head and neck account for only 3.2% of biopsies. This distinction is important, however, because of the Call malignancies diagnosed in the United States and inherent differences in biology, natural history, prognosis, and only 3.6% of these occur in the sinonasal tract, making treatment among these neoplasms. The aim of this study is to sinonasal malignancies exceedingly rare. In addition to identify a limited immunohistochemical panel that may help to the relatively common squamous cell carcinoma, there are differentiate these morphologically similar small cell epithelial many other clinically aggressive high-grade malignant malignancies. neoplasms that can arise in this complex anatomic region. Many of these high-grade tumors fall under the general Design: We reviewed 37 cases of histologically similar small cell category of small cell malignant neoplasms. epithelial malignancies of the sinonasal cavity and

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: May 1, 2009

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