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- Publisher
- Wiley
- Copyright
- Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0908-665X
- eISSN
- 1399-3089
- DOI
- 10.1111/j.1399-3089.2006.00285.x
- pmid
- 16623798
- Publisher site
- See Article on Publisher Site
Abstract
Abbreviations: AB, antibody; AVR, acute vascular rejection; Gal, g alactose‐α1,3‐galactose; GalT‐KO, α1,3‐galactosyltransferase gene knockout; PAEC, porcine aortic endothelial cells; PCV‐1, porcine circovirus type 1; PERV, porcine endogenous retrovirus; SDS, sodium dodecyl sulfate; SLA, swine leukocyte antigen. Reviews During the period November to December 2005, 11 reviews on xenotransplantation were published [ 1–11 ]. Galili reviewed the ontology and role for xenotransplantation, hyperacute rejection and cancer immunotherapy of the galactose‐α1,3‐galactose (Gal) epitope and anti‐Gal antibodies [ 8 ]. Fadiel et al. [ 9 ] provided an update on animal farm genomics and bioinformatics and reviewed recent advances in biotechnology in the farming industry, a field closely related to xenotransplantation. Pre‐clinical studies Tseng et al. [ 12 ] transplanted, heterotopically, eight baboons with α1,3‐galactosyltransferase gene‐knockout (GalT‐KO) pig hearts and studied graft survival and the type of rejection. The immunosuppressive regimen included an anti‐CD154 monoclonal antibody (Ab), mycophenolate mofetil and steroids. Heparin and aspirin were also given to delay onset and progression of thrombotic microangiopathy. In six of eight baboons, the authors observed a graft survival of 2 to 6 months, with loss of all grafts related to thrombotic microangiopathy. It remains unclear whether this event was secondary to a low
Journal
Xenotransplantation – Wiley
Published: Mar 1, 2006