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Xenotransplantation literature update, May/June 2017

Xenotransplantation literature update, May/June 2017 Management of the perioperative phase of pig to baboon cardiac xenotransplantations could affect experimental outcomes. Mayr et al. compared the perioperative hemodynamics and laboratory findings from orthotopic (n=5) and heterotopic (n=23) cardiac transplants. Several factors such as hemodynamics, respiratory function, and survival as well as organ damage were measured 12 hour after transplantation. Cardiopulmonary bypass time was significantly lower in the heterotopic transplants (median 144 minutes) compared to orthotopic (median 171 minutes). In a majority of the heterotopic transplants, no inotropics were used; however, in four of the five epinephrine was administrated. In addition, the time for administration of catecholamine was longer in the orthotopic when compared to the heterotopic transplants as well it appears easier to wean the heterotopic transplants off of the respirator even with impaired pulmonary function.There are many reasons for acute liver failure; however, recovery is based on ability of the liver to regenerate as well as hepatocyte necrosis. Acute liver failure therapy may be accomplished with hepatocyte transplants, which may provide temporary liver function while the patient's liver repairs or they await a liver transplant. Machaidze et al. investigated the efficacy of microencapsulation of porcine hepatocytes in a large animal model for fulminant liver failure. Porcine hepatocytes were transplanted http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Xenotransplantation literature update, May/June 2017

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References (8)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12323
pmid
28741697
Publisher site
See Article on Publisher Site

Abstract

Management of the perioperative phase of pig to baboon cardiac xenotransplantations could affect experimental outcomes. Mayr et al. compared the perioperative hemodynamics and laboratory findings from orthotopic (n=5) and heterotopic (n=23) cardiac transplants. Several factors such as hemodynamics, respiratory function, and survival as well as organ damage were measured 12 hour after transplantation. Cardiopulmonary bypass time was significantly lower in the heterotopic transplants (median 144 minutes) compared to orthotopic (median 171 minutes). In a majority of the heterotopic transplants, no inotropics were used; however, in four of the five epinephrine was administrated. In addition, the time for administration of catecholamine was longer in the orthotopic when compared to the heterotopic transplants as well it appears easier to wean the heterotopic transplants off of the respirator even with impaired pulmonary function.There are many reasons for acute liver failure; however, recovery is based on ability of the liver to regenerate as well as hepatocyte necrosis. Acute liver failure therapy may be accomplished with hepatocyte transplants, which may provide temporary liver function while the patient's liver repairs or they await a liver transplant. Machaidze et al. investigated the efficacy of microencapsulation of porcine hepatocytes in a large animal model for fulminant liver failure. Porcine hepatocytes were transplanted

Journal

Xenotransplantation – Wiley

Published: Jul 1, 2017

Keywords: ; ; ;

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