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Xenotransplantation literature update March–April, 2009

Xenotransplantation literature update March–April, 2009 Abbreviations: αGal galactose‐α1,3‐galactose DAF decay accelerating factor EGFP enhanced green fluorescent protein GT‐KO α1,3‐galactosyltransferase gene knockout HLA human leukocyte antigen HT α‐1,2‐fucosyltransferase IEQ total islet equivalents IEQ/g islet equivalents per gram of pancreas IL interleukin LTR long‐terminal repeats NK natural killer cells PBMC peripheral blood mononuclear cellsl PD‐1 programmed death 1 PD‐L PD‐1 ligand pEC porcine endothelial cells PERV porcine endogenous retrovirus TEM transendothelial migration TF tissue factor TM thrombotic microangiopathy TRIM5α tripartite motif 5α Reviews During the period March–April, 2009, nine reviews on different aspects of xenotransplantation were published, six of which appeared in the April issue of Current Opinion in Organ Transplantation, edited by Gilles Blancho. Sachs and Galli [ 1 ] reviewed recent developments in the techniques and applications of genetically modified animals. The authors summarized existing and emerging technologies, including enzymatic engineering and the use of small interfering RNA, as well as recent data on xenotransplantation models using genetically modified donor animals. They concluded that new transgenic and knockout animals, potentially modified for individual organs, need to be generated on the background of inbred pigs, and mentioned the European Union’s Xenome project. Cowan et al. recently published two reviews [ 2,3 ] on different http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Xenotransplantation literature update March–April, 2009

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References (22)

Publisher
Wiley
Copyright
© 2009 John Wiley & Sons A/S
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/j.1399-3089.2009.00529.x
pmid
19566658
Publisher site
See Article on Publisher Site

Abstract

Abbreviations: αGal galactose‐α1,3‐galactose DAF decay accelerating factor EGFP enhanced green fluorescent protein GT‐KO α1,3‐galactosyltransferase gene knockout HLA human leukocyte antigen HT α‐1,2‐fucosyltransferase IEQ total islet equivalents IEQ/g islet equivalents per gram of pancreas IL interleukin LTR long‐terminal repeats NK natural killer cells PBMC peripheral blood mononuclear cellsl PD‐1 programmed death 1 PD‐L PD‐1 ligand pEC porcine endothelial cells PERV porcine endogenous retrovirus TEM transendothelial migration TF tissue factor TM thrombotic microangiopathy TRIM5α tripartite motif 5α Reviews During the period March–April, 2009, nine reviews on different aspects of xenotransplantation were published, six of which appeared in the April issue of Current Opinion in Organ Transplantation, edited by Gilles Blancho. Sachs and Galli [ 1 ] reviewed recent developments in the techniques and applications of genetically modified animals. The authors summarized existing and emerging technologies, including enzymatic engineering and the use of small interfering RNA, as well as recent data on xenotransplantation models using genetically modified donor animals. They concluded that new transgenic and knockout animals, potentially modified for individual organs, need to be generated on the background of inbred pigs, and mentioned the European Union’s Xenome project. Cowan et al. recently published two reviews [ 2,3 ] on different

Journal

Xenotransplantation – Wiley

Published: May 1, 2009

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