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Xenotransplantation literature update, July/August 2017

Xenotransplantation literature update, July/August 2017 AbbreviationshGal‐9human galectin‐9iPSCsinduced pluripotent stem cellsPIECsporcine iliac endothelial cellsXENOGENEIC CHIMERAOldani and colleagues reviewed the historical progress of blastocyte complementation and discussed the potential challenges, technological aspects, economic implications, and ethical limitations of the generation of human‐pig chimera using this technology. Initially, successful usage of pluripotent stem cells (iPSCs) for organ complementation in rodents with gene deletions, and the successful generation of chimeric mice using rat iPSCs and vice versa, validated the feasibility of this technology, across species barriers (at least in the concordant xenogeneic combination). Of note, the authors indicate that these studies demonstrated that the success of these chimera was organ‐dependent. The authors suggest that the generation of the pig‐human chimera may prove more difficult, mainly due to the less effective generation of pig‐human than mouse‐rat chimera, the variability in embryonic development across discordant species, and the potential of arrested development of chimeric embryos in utero. Also, the authors point out that residual host (pig) tissues after successful generation of pig‐human chimera can still pose an increased risk of rejection after transplantation.TRANSGENIC HUMAN GALECTIN‐9Han Jung et al evaluated in vitro the immunoregulatory influence of transgenic expression human galectin‐9 (hGal‐9) by porcine kidney cells on the cytotoxic effects by human monocytes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Xenotransplantation literature update, July/August 2017

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References (7)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12340
pmid
28891168
Publisher site
See Article on Publisher Site

Abstract

AbbreviationshGal‐9human galectin‐9iPSCsinduced pluripotent stem cellsPIECsporcine iliac endothelial cellsXENOGENEIC CHIMERAOldani and colleagues reviewed the historical progress of blastocyte complementation and discussed the potential challenges, technological aspects, economic implications, and ethical limitations of the generation of human‐pig chimera using this technology. Initially, successful usage of pluripotent stem cells (iPSCs) for organ complementation in rodents with gene deletions, and the successful generation of chimeric mice using rat iPSCs and vice versa, validated the feasibility of this technology, across species barriers (at least in the concordant xenogeneic combination). Of note, the authors indicate that these studies demonstrated that the success of these chimera was organ‐dependent. The authors suggest that the generation of the pig‐human chimera may prove more difficult, mainly due to the less effective generation of pig‐human than mouse‐rat chimera, the variability in embryonic development across discordant species, and the potential of arrested development of chimeric embryos in utero. Also, the authors point out that residual host (pig) tissues after successful generation of pig‐human chimera can still pose an increased risk of rejection after transplantation.TRANSGENIC HUMAN GALECTIN‐9Han Jung et al evaluated in vitro the immunoregulatory influence of transgenic expression human galectin‐9 (hGal‐9) by porcine kidney cells on the cytotoxic effects by human monocytes.

Journal

Xenotransplantation – Wiley

Published: Sep 1, 2017

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