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R. Race, R. Sanger (1980)
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J. Mendlewicz, P. Linkowski, J. Guroff, H. Praag (1979)
Color blindness linkage to bipolar manic-depressive illness. New evidence.Archives of general psychiatry, 36 13
J. Mendlewicz, J. Rainer (1974)
Morbidity risk and genetic transmission in manic-depressive illness.American journal of human genetics, 26 6
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Raymond Crowe, Peter Smouse (1977)
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N. Morton (1956)
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Colorblindness not closely linked to bipolar illness
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Linkage between an X-chromosome marker (deutan-colorblindness) and bipolar affective BARON
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Colorblindness linkage to bipolar manic-depressive illness
C. Smith (1959)
Some comments on the statistical methods used in linkage investigations.American journal of human genetics, 11
Elliot Gershon, Targum Sd, Steven Matthysse, William Bunney (1979)
Color blindness not closely linked to bipolar illness. Report of a new pedigree series.Archives of general psychiatry, 36 13
L. Morton, K. Kidd (1980)
The effects of variable age-of-onset and diagnostic criteria on the estimates of linkage: an example using manic-depressive illness and color blindness.Social biology, 27 1
Cedric Smith (1968)
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Miron Baron, John Rainer, Neil Risch (1981)
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G. Winokur, P. Clayton (1967)
Family History Studies
J. Mendlewicz (1977)
Genetic Studies in Schizoaffective Illness
Julien Mendlewicz, Paul Linkowski, Jean Wilmotte (1980)
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E. Gershon, S. Matthysse (1977)
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SUMMARY It has been suggested that an X‐linked dominant allele operates in the genetic transmission of bipolar (manic‐depressive) illness. Linkage studies with X‐chromosome markers have remained inconclusive, showing both positive and negative results. Some of the ambiguity may be attributed to imprecise analytic methods and genetic heterogeneity. In this report, recently published pedigree series are reanalysed for linkage using a systematic method of pedigree analysis (Liped 3) with an accurate age‐of‐onset correction. Linkage heterogeneity is assessed through a two‐recombination fraction heterogeneity test suggested by Smith (1963). The results are as follows: (1) Close linkage of bipolar illness to colourblindness (deutan and protan) and glucose‐6‐phosphate dehydrogenase deficiency appears to be present in some pedigrees, with estimated recombination fractions of θ= 0.05 and 0.00, respectively; (2) Linkage with the Xg blood group cannot be supported. These results are consistent with known linkages on the X chromosome.
Annals of Human Genetics – Wiley
Published: May 1, 1982
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