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The rising number of multidrug‐resistant microorganisms has triggered interest in the prospection of biocompounds with antimicrobial activities. Synoeca‐MP consists of an antimicrobial peptide (AMP) classified as a mastoparan, which was isolated from the venom of Synoeca surinama, a social wasp. Synoeca‐MP presented a potent antimicrobial activity, with values of MIC50 and MIC90 against methicillin‐resistant Staphylococcus aureus—MRSA (1.9 and 2.2 μM), Escherichia coli ESBL (2.0 and 2,1 μM), vancomycin‐resistant Enterococcus faecalis (8.3 and 17.1 μM), Pseudomonas aeruginosa metallo‐ß‐lactamase (5.2 and 5.9 μM), and Klebsiella pneumoniae KPC (3.5 and 4.7 μM). Synoeca‐MP was also tested against six Candida species, with MICs varying from 10 to 40 μM. Moreover, the structural prediction for Synoeca‐MP demonstrated a cationic α‐helix capable of interacting with in silico membranes and low hemolytic activity. Due to its antimicrobial activity, synoeca‐MP shows potential as an adjuvant to antibiotics and antifungals commonly used in antibiotic therapies.
Peptide Science – Wiley
Published: May 1, 2020
Keywords: ; ;
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