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Cardiovascular Reseurch Foundution, Washington Hospital Center, Washington, DC Endovascular radiation has been developed in the last decade as a new modality for prevention of restenosis and a new subspecialty for cardiologists and radiation therapists. Emerging from extensive preclinical and pioneering feasibility clinical trials in peripheral and coronary arterial systems, a new field was born. Numerous preclinical studies in the porcine model have clearly demonstrated complete inhibition of the neointima and absence of luminal renarrowing when the right dose was administered intraluminally and reached the right target following vessel injury by balloon or stent. The feasibility clinical trials of applying vascular brachytherapy in the peripheral artery by Liermann and Schopol' with nearly 8 years of clinical follow-up are currently the longest follow-up data available. In addition the fact that the first wave of clinical trials in coronary arteries performed by Condado,2.3 Verin4 Teirstein,596 King' and Waksman* all have reached > 2 years clinical and angiographic follow-up provides comfort regarding the long-term safety of this technology. This fascinating field raises research opportunities in different directions. This special issue on vascular brachytherapy for the Journal of Interventional Cardiology is an attempt to touch on some of the important questions related to
Journal of Interventional Cardiology – Wiley
Published: Aug 1, 1999
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