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Variants of red cell ǵlucose‐6‐p‐hosphate dehydroǵenase amonǵ Asiatic Indians

Variants of red cell ǵlucose‐6‐p‐hosphate dehydroǵenase amonǵ Asiatic Indians SUMMARY Among one hundfed and one unrelated Asiatic Indian males living in the Pacific north‐west, five G‐6‐PD‐deficient individuals were identified. The enzyme of three of these individuals was indistinguished elctrophoreticaly and biochemically from the Mediterranean type of deficiency. These individuals originated from the north‐western parts of the Indian subcontinent. The enzyme of one individual and that of his subsequently studied beother (G‐6‐PD Kerala) was found to be simialr to G‐6‐PD Seattle by km G‐6‐P, km TPN, pH optimum, utilization of 2d‐g‐6P and Gal‐6‐P and electrophoretic migration rate in Tris buffer, pH 8.8. Electrophoresis on TEB buffer (pH 8.6) however, showed this variant to be different from G‐6‐PD Seattle, The desirability of using multiple electrophoretic methods in the elucidation of new variants is emphasized by these observations. The third abmormal G‐6‐PD (G‐6‐PD West Bengal) was unlike other mutations previously described in having higher‐than normal km TPN and lower‐than‐normal km G‐6‐P and a slow electrophoretic mobilty. The identification of the Mediterranean type of G‐6‐PD deficiency in the north‐western part of the Indian subcontinent, together with histrorical and molecular considerations, suggests affiinities of Mediterranean, Near Eastern, and North‐west Indian populations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Variants of red cell ǵlucose‐6‐p‐hosphate dehydroǵenase amonǵ Asiatic Indians

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References (28)

Publisher
Wiley
Copyright
Copyright © 1968 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1968.tb00569.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY Among one hundfed and one unrelated Asiatic Indian males living in the Pacific north‐west, five G‐6‐PD‐deficient individuals were identified. The enzyme of three of these individuals was indistinguished elctrophoreticaly and biochemically from the Mediterranean type of deficiency. These individuals originated from the north‐western parts of the Indian subcontinent. The enzyme of one individual and that of his subsequently studied beother (G‐6‐PD Kerala) was found to be simialr to G‐6‐PD Seattle by km G‐6‐P, km TPN, pH optimum, utilization of 2d‐g‐6P and Gal‐6‐P and electrophoretic migration rate in Tris buffer, pH 8.8. Electrophoresis on TEB buffer (pH 8.6) however, showed this variant to be different from G‐6‐PD Seattle, The desirability of using multiple electrophoretic methods in the elucidation of new variants is emphasized by these observations. The third abmormal G‐6‐PD (G‐6‐PD West Bengal) was unlike other mutations previously described in having higher‐than normal km TPN and lower‐than‐normal km G‐6‐P and a slow electrophoretic mobilty. The identification of the Mediterranean type of G‐6‐PD deficiency in the north‐western part of the Indian subcontinent, together with histrorical and molecular considerations, suggests affiinities of Mediterranean, Near Eastern, and North‐west Indian populations.

Journal

Annals of Human Genetics – Wiley

Published: May 1, 1968

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