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Variants in Intron 13 of the ELMO1 Gene are Associated with Diabetic Nephropathy in African Americans

Variants in Intron 13 of the ELMO1 Gene are Associated with Diabetic Nephropathy in African... Variants in the engulfment and cell motility 1 (ELMO1) gene are associated with nephropathy due to type 2 diabetes mellitus (T2DM) in a Japanese cohort. We comprehensively evaluated this gene in African American (AA) T2DM patients with end‐stage renal disease (ESRD). Three hundred and nine HapMap tagging SNPs and 9 reportedly associated SNPs were genotyped in 577 AA T2DM‐ESRD patients and 596 AA non‐diabetic controls, plus 43 non‐diabetic European American controls and 45 Yoruba Nigerian samples for admixture adjustment. Replication analyses were conducted in 558 AA with T2DM‐ESRD and 564 controls without diabetes. Extension analyses included 328 AA with T2DM lacking nephropathy and 326 with non‐diabetic ESRD. The original and replication analyses confirmed association with four SNPs in intron 13 (permutation p‐values for combined analyses = 0.001–0.003), one in intron 1 (P = 0.004) and one in intron 5 (P = 0.002) with T2DM‐associated ESRD. In a subsequent combined analysis of all 1,135 T2DM‐ESRD cases and 1,160 controls, an additional 7 intron 13 SNPs produced evidence of association (P = 3.5 × 10−5– P = 0.05). No associations were seen with these SNPs in those with T2DM lacking nephropathy or with ESRD due to non‐diabetic causes. Variants in intron 13 of the ELMO1 gene appear to confer risk for diabetic nephropathy in AA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Variants in Intron 13 of the ELMO1 Gene are Associated with Diabetic Nephropathy in African Americans

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References (14)

Publisher
Wiley
Copyright
Copyright © 2009 Wiley Subscription Services
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.2008.00498.x
pmid
19183347
Publisher site
See Article on Publisher Site

Abstract

Variants in the engulfment and cell motility 1 (ELMO1) gene are associated with nephropathy due to type 2 diabetes mellitus (T2DM) in a Japanese cohort. We comprehensively evaluated this gene in African American (AA) T2DM patients with end‐stage renal disease (ESRD). Three hundred and nine HapMap tagging SNPs and 9 reportedly associated SNPs were genotyped in 577 AA T2DM‐ESRD patients and 596 AA non‐diabetic controls, plus 43 non‐diabetic European American controls and 45 Yoruba Nigerian samples for admixture adjustment. Replication analyses were conducted in 558 AA with T2DM‐ESRD and 564 controls without diabetes. Extension analyses included 328 AA with T2DM lacking nephropathy and 326 with non‐diabetic ESRD. The original and replication analyses confirmed association with four SNPs in intron 13 (permutation p‐values for combined analyses = 0.001–0.003), one in intron 1 (P = 0.004) and one in intron 5 (P = 0.002) with T2DM‐associated ESRD. In a subsequent combined analysis of all 1,135 T2DM‐ESRD cases and 1,160 controls, an additional 7 intron 13 SNPs produced evidence of association (P = 3.5 × 10−5– P = 0.05). No associations were seen with these SNPs in those with T2DM lacking nephropathy or with ESRD due to non‐diabetic causes. Variants in intron 13 of the ELMO1 gene appear to confer risk for diabetic nephropathy in AA.

Journal

Annals of Human Genetics – Wiley

Published: Jan 1, 2009

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