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Unscheduled DNA synthesis, u.v.‐induced chromosome aberrations adn SV 40 transformation in cultured cells from xeroderma pigmentosum

Unscheduled DNA synthesis, u.v.‐induced chromosome aberrations adn SV 40 transformation in... Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV,, transformation in cultured cells from xeroderma pigmentosum BY JENNIFER M. PARRINGTON, JOY D. A. DELHANTY AND HOWARD P. BADEN" MRC Human Biochemical Genetics Unit and Galton Laboratory, University College London Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disease (El-Hefnawi, Maynard Smith & Penrose, 1965) characterized by extreme sensitivity to sunlight and a greatly increased susceptibility to carcinomas and melanomas of the skin. A severe deficiency or complete absence of DNA repair replication following 2537A. U.V. irradiation has been demonstrated in both cultured fibroblasts (Cleaver, 1968; Bootsma, Mulder, Pot & Cohen, 1970) and lymphocytes (Burk, Lutzner & Robbins, 1969) from these patients. Recent work has suggested that the initial step in the repair mechanism - the recognition and excision of thymine dimers, is deficient in xeroderma cells (Setlow, Regan, German & Carrier, 1969; Cleaver, 1969; Cleaver & Trosko, 1970). The retention of pyrimidine dimers in the DNA of skin cells thus directly or indirectly predisposes the cells to neoplastic change. Normal human cells can be photosensitized to long-wavelength U.V. radiation by treatment with the furocoumarin trisoralen (Trosko & Isoun, 1971). Pathak & Kramer (1969) have demonstrated that furocoumarins form http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Unscheduled DNA synthesis, u.v.‐induced chromosome aberrations adn SV 40 transformation in cultured cells from xeroderma pigmentosum

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References (33)

Publisher
Wiley
Copyright
Copyright © 1971 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1956.tb01387.x
Publisher site
See Article on Publisher Site

Abstract

Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV,, transformation in cultured cells from xeroderma pigmentosum BY JENNIFER M. PARRINGTON, JOY D. A. DELHANTY AND HOWARD P. BADEN" MRC Human Biochemical Genetics Unit and Galton Laboratory, University College London Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disease (El-Hefnawi, Maynard Smith & Penrose, 1965) characterized by extreme sensitivity to sunlight and a greatly increased susceptibility to carcinomas and melanomas of the skin. A severe deficiency or complete absence of DNA repair replication following 2537A. U.V. irradiation has been demonstrated in both cultured fibroblasts (Cleaver, 1968; Bootsma, Mulder, Pot & Cohen, 1970) and lymphocytes (Burk, Lutzner & Robbins, 1969) from these patients. Recent work has suggested that the initial step in the repair mechanism - the recognition and excision of thymine dimers, is deficient in xeroderma cells (Setlow, Regan, German & Carrier, 1969; Cleaver, 1969; Cleaver & Trosko, 1970). The retention of pyrimidine dimers in the DNA of skin cells thus directly or indirectly predisposes the cells to neoplastic change. Normal human cells can be photosensitized to long-wavelength U.V. radiation by treatment with the furocoumarin trisoralen (Trosko & Isoun, 1971). Pathak & Kramer (1969) have demonstrated that furocoumarins form

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1971

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