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J. Cleaver (1970)
DNA repair and radiation sensitivity in human (xeroderma pigmentosum) cells.International journal of radiation biology and related studies in physics, chemistry, and medicine, 18 6
(1968)
Unscheduled incorporation of thymidine in ultraviolet irradiated human IGALI
S. Igali, B. Bridges, M. Ashwood‐Smith, B. Scott (1970)
Mutagenesis in Escherichia coli. IV. Photosensitization to near ultraviolet light by 8-methoxypsoralen.Mutation research, 9 1
G. Veldhuisen, P. Pouwels (1970)
TRANSFORMATION OF XERODERMA-PIGMENTOSUM CELLS BY SV40The Lancet, 296
S. Aaronson, G. Todaro (1968)
SV40 T antigen induction and transformation in human fibroblast cell strains.Virology, 36 2
P. Moorhead, P. Nowell, W. Mellman, D. Battips, D. Hungerford (1960)
Chromosome preparations of leukocytes cultured from human peripheral blood.Experimental cell research, 20
J. Cleaver, James Trosko (1970)
ABSENCE OF EXCISION OF ULTRAVIOLET‐INDUCED CYCLOBUTANE DIMERS IN XERODERMA PIGMENTOSUM *Photochemistry and Photobiology, 11
J. Trosko, M. Isoun (1971)
Photosensitizing effect of trisoralen on DNA synthesis in human cells grown in vitro.International journal of radiation biology and related studies in physics, chemistry, and medicine, 19 1
S. Aaronson (1970)
Susceptibility of Human Cell Strains to Transformation by Simian Virus 40 and Simian Virus 40 Deoxyribonucleic AcidJournal of Virology, 6
(1970)
Mutagenesis in E
(1969)
Decreased incorporation of thymidine into the DNA coll strzhins
S. Aaronson, C. Lytle (1970)
Decreased Host Cell Reactivation of Irradiated SV40 Virus in Xeroderma PigmentosumNature, 228
(1965)
Xeroderma pigmentosum - its inheri
Burk (1969)
Decreased incorporation of thymidine into the DNA of lymphoeytes from patients with xeroderma pigmentosum after UV-irradiationin vitroClin. Res, 17
(1970)
Decreased host cell roactivation of irradiated S V 4 0 virus
Lond. 28, 273. lymphocytes. Radiat. Res. 36, 281. Photosensitization to near ultraviolet light by 8-methoxypsoralen
Madhu Pathak, D. Krämer (1969)
Photosensitization of skin in vivo by furocoumarins (psoralens).Biochimica et biophysica acta, 195 1
D. Smithers, J. Wood (1952)
Xeroderma pigmentosum; an attempt at cancer prophylaxis.Lancet, 1 6715
(1960)
Chromosome preparations of leucocytes cultured from human peripheral blood
BY Setlow, J. Regan, James German, W. Carrier (1969)
Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA.Proceedings of the National Academy of Sciences of the United States of America, 64 3
(1968)
SV 40 T antigen induction and transforinntion in human fibroblast AARONSON
J. Cleaver (1968)
Defective Repair Replication of DNA in Xeroderma PigmentosumNature, 218
Koller Pc (1948)
Inheritance of Xeroderma and its Chromosome MechanismBritish Journal of Cancer, 2
(1969)
Xeroderma pigmentosum: a human disease in which an initial stage of DNA repair CLEAVER
By Cleaver (1969)
Xeroderma pigmentosum: a human disease in which an initial stage of DNA repair is defective.Proceedings of the National Academy of Sciences of the United States of America, 63 2
Richard Evans, A. Norman (1968)
Unscheduled incorporation of thymidine in ultraviolet-irradiated human lymphocytes.Radiation research, 36 2
D. Bootsma, M. Mulder, J. Cohen, F. Pot (1970)
Different inherited levels of DNA repair replication in xeroderma pigmentosum cell strains after exposure to ultraviolet irradiation.Mutation research, 9 5
Burk (1971)
Ultraviolet-stimulated thymidine incorporation in xeroderma pigmenttosum lymphocytes.J. Lab. Cliln. Med, 77
J. Robbins, P. Burk, W. Levis (1970)
Rapid and sensitive assay for D.N.A. synthesis in leucocyte cultures.Lancet, 1 7663
(1970)
Transformation of xeroderma pigmentosum cells by SV 40. Lancet ii, 529. is defective
G. Todaro, H. Green, Michael Swift (1966)
Susceptibility of Human Diploid Fibroblast Strains to Transformation by SV40 VirusScience, 153
H. El‐Hefnawi, S. Smith, L. Penrose (1964)
Xeroderma pigmentosum‐its inheritance and relationship to the ABO blood‐group systemAnnals of Human Genetics, 28
(1971)
Ultraviolet-stimulated thymidine BURK
Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV,, transformation in cultured cells from xeroderma pigmentosum BY JENNIFER M. PARRINGTON, JOY D. A. DELHANTY AND HOWARD P. BADEN" MRC Human Biochemical Genetics Unit and Galton Laboratory, University College London Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disease (El-Hefnawi, Maynard Smith & Penrose, 1965) characterized by extreme sensitivity to sunlight and a greatly increased susceptibility to carcinomas and melanomas of the skin. A severe deficiency or complete absence of DNA repair replication following 2537A. U.V. irradiation has been demonstrated in both cultured fibroblasts (Cleaver, 1968; Bootsma, Mulder, Pot & Cohen, 1970) and lymphocytes (Burk, Lutzner & Robbins, 1969) from these patients. Recent work has suggested that the initial step in the repair mechanism - the recognition and excision of thymine dimers, is deficient in xeroderma cells (Setlow, Regan, German & Carrier, 1969; Cleaver, 1969; Cleaver & Trosko, 1970). The retention of pyrimidine dimers in the DNA of skin cells thus directly or indirectly predisposes the cells to neoplastic change. Normal human cells can be photosensitized to long-wavelength U.V. radiation by treatment with the furocoumarin trisoralen (Trosko & Isoun, 1971). Pathak & Kramer (1969) have demonstrated that furocoumarins form
Annals of Human Genetics – Wiley
Published: Oct 1, 1971
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