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M. Farag, D. Huhman, Zhentian Lei, L. Sumner (2007)
Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS.Phytochemistry, 68 3
Nayumi Akimoto, T. Ara, D. Nakajima, K. Suda, Chiaki Ikeda, Shingo Takahashi, Reiko Muneto, M. Yamada, Hideyuki Suzuki, D. Shibata, N. Sakurai (2017)
FlavonoidSearch: A system for comprehensive flavonoid annotation by mass spectrometryScientific Reports, 7
Chad Johnston, M. Skinnider, Morgan Wyatt, Xiang Li, Michael Ranieri, Lian Yang, D. Zechel, Bin Ma, N. Magarvey (2015)
An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural productsNature Communications, 6
H. Röst, Timo Sachsenberg, Stephan Aiche, C. Bielow, Hendrik Weisser, Fabian Aicheler, S. Andreotti, Hans-Christian Ehrlich, Petra Gutenbrunner, E. Kenar, X. Liang, S. Nahnsen, L. Nilse, J. Pfeuffer, George Rosenberger, Marc Rurik, Uwe Schmitt, Johannes Veit, Mathias Walzer, David Wojnar, W. Wolski, O. Schilling, J. Choudhary, L. Malmström, R. Aebersold, K. Reinert, O. Kohlbacher (2016)
OpenMS: a flexible open-source software platform for mass spectrometry data analysisNature Methods, 13
Zhentian Lei, L. Jing, Feng Qiu, Hua Zhang, D. Huhman, Zhiqin Zhou, L. Sumner (2015)
Construction of an Ultrahigh Pressure Liquid Chromatography-Tandem Mass Spectral Library of Plant Natural Products and Comparative Spectral Analyses.Analytical chemistry, 87 14
J. Watson, Emily Greenough, J. Leet, M. Ford, D. Drexler, James Belcastro, J. Herbst, M. Chatterjee, M. Banks (2009)
Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic TipsJournal of Biomolecular Screening, 14
Shouchuang Wang, Chenkun Yang, Hong Tu, Junjie Zhou, Xianqing Liu, Yunjiang Cheng, Jie Luo, X. Deng, Hongyan Zhang, Juan Xu (2017)
Characterization and Metabolic Diversity of Flavonoids in Citrus SpeciesScientific Reports, 7
M. Cho, L. Howard, R. Prior, J. Clark (2004)
Flavonoid glycosides and antioxidant capacity of various blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometryJournal of the Science of Food and Agriculture, 84
Zhuan-Hong Li, Han Guo, Wenbin Xu, Juan Ge, Xin Li, Mireguli Alimu, Dajun He (2016)
Rapid Identification of Flavonoid Constituents Directly from PTP1B Inhibitive Extract of Raspberry (Rubus idaeus L.) Leaves by HPLC-ESI-QTOF-MS-MS.Journal of chromatographic science, 54 5
C. Santos‐Buelga, C. Garcia‐Viguera, F. A. TomasS‐Barbern (2003)
Royal Society of Chemistry (Great Britain)
H. Horai, Masanori Arita, S. Kanaya, Yoshito Nihei, Tasuku Ikeda, Kazuhiro Suwa, Y. Ojima, Kenichi Tanaka, Satoshi Tanaka, K. Aoshima, Y. Oda, Yuji Kakazu, M. Kusano, Takayuki Tohge, Fumio Matsuda, Y. Sawada, M. Hirai, H. Nakanishi, Kazutaka Ikeda, N. Akimoto, T. Maoka, Hiroki Takahashi, T. Ara, N. Sakurai, H. Suzuki, D. Shibata, S. Neumann, T. Iida, Kenichi Tanaka, K. Funatsu, Fumito Matsuura, T. Soga, R. Taguchi, K. Saito, T. Nishioka (2010)
MassBank: a public repository for sharing mass spectral data for life sciences.Journal of mass spectrometry : JMS, 45 7
Eva Rijke, P. Out, W. Niessen, F. Ariese, C. Gooijer, U. Brinkman (2006)
Analytical separation and detection methods for flavonoids.Journal of chromatography. A, 1112 1-2
Zhentian Lei, D. Huhman, L. Sumner (2011)
Mass Spectrometry Strategies in Metabolomics*The Journal of Biological Chemistry, 286
D. Wishart, Y. Feunang, A. Marcu, Anchi Guo, Kevin Liang, R. Vázquez-Fresno, Tanvir Sajed, Daniel Johnson, Carin Li, N. Karu, Zinat Sayeeda, Elvis Lo, Nazanin Assempour, M. Berjanskii, Sandeep Singhal, David Arndt, Yongjie Liang, Hasan Badran, J. Grant, Arnau Serra-Cayuela, Yifeng Liu, R. Mandal, V. Neveu, Allison Pon, Craig Knox, Michael Wilson, C. Manach, A. Scalbert (2017)
HMDB 4.0: the human metabolome database for 2018Nucleic Acids Research, 46
Feng Qiu, D. Fine, Daniel Wherritt, Zhentian Lei, L. Sumner (2016)
PlantMAT: A Metabolomics Tool for Predicting the Specialized Metabolic Potential of a System and for Large-Scale Metabolite Identifications.Analytical chemistry, 88 23
Colin Smith, E. Want, Grace O'Maille, R. Abagyan, G. Siuzdak (2006)
XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.Analytical chemistry, 78 3
J. Xia, D. Wishart (2016)
Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data AnalysisCurrent Protocols in Bioinformatics, 55
H. Tsugawa, T. Cajka, T. Kind, Yan Ma, Brendan Higgins, K. Ikeda, Mitsuhiro Kanazawa, J. VanderGheynst, O. Fiehn, Masanori Arita (2015)
MS-DIAL: Data Independent MS/MS Deconvolution for Comprehensive Metabolome AnalysisNature methods, 12
Flavonoids are a class of specialized metabolites found in many different plant species. They protect against UV radiation, scavenge reactive oxygen species, are involved in plant defense responses, and are associated with plant‐microorganism interactions. They have also been reported to possess health‐promoting effects including anti‐inflammatory, antioxidant, anticancer activity, and antihypertensive effects. Flavonoids encompass >10,000 structures where the types and amounts depend on the plant species, developmental stage, organ, and growth conditions. The diversity of flavonoid structures represents a significant challenge in the analysis of plant flavonoids. Many analytical techniques have been developed to detect and quantify flavonoids, and the most productive of these techniques use liquid chromatography (LC) coupled to mass spectrometry (MS) to analyze flavonoids due to the excellent combination of selectivity and sensitivity of MS. In addition, mass spectral libraries have been constructed to further aid flavonoid identification. Here, the use of ultra‐high pressure liquid chromatography coupled to mass spectrometry (UHPLC‐MS) in plant flavonoid analyses, with an emphasis on sample extraction, flavonoid separation, and MS detection, is described. © 2018 by John Wiley & Sons, Inc.
Current Protocols in Plant Biology – Wiley
Published: Mar 1, 2019
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