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Two crystal forms of a helix‐rich fatty acid‐ and retinol‐binding protein, Na‐FAR‐1, from the parasitic nematode Necator americanus

Two crystal forms of a helix‐rich fatty acid‐ and retinol‐binding protein, Na‐FAR‐1, from the... Na‐FAR‐1 is an unusual α‐helix‐rich fatty acid‐ and retinol‐binding protein from Necator americanus, a blood‐feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit‐cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit‐cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Crystallographica Section F Wiley

Two crystal forms of a helix‐rich fatty acid‐ and retinol‐binding protein, Na‐FAR‐1, from the parasitic nematode Necator americanus

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References (39)

Publisher
Wiley
Copyright
International Union of Crystallography, 2012
ISSN
1744-3091
eISSN
1744-3091
DOI
10.1107/S1744309112023597
pmid
22750878
Publisher site
See Article on Publisher Site

Abstract

Na‐FAR‐1 is an unusual α‐helix‐rich fatty acid‐ and retinol‐binding protein from Necator americanus, a blood‐feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit‐cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit‐cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.

Journal

Acta Crystallographica Section FWiley

Published: Jul 1, 2012

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