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Trials of the European Working Party on Streptokinase and of the European Cooperative Study Group on Alteplase in Patients with Acute Myocardial Infarction

Trials of the European Working Party on Streptokinase and of the European Cooperative Study Group... Trials of the European Working Party on Streptokinase and of the European Cooperative Working Group on tPA in Patients with Acute Myocardial Infarction The first trial of the European Working Party was commenced in 1962 at a time when no controlled, strictly randomized, large scale trials on the clinical use of thrombolytic drugs in patients with recent myocardial infarction (MI) were available. At that time, the frequency with which a fresh thrombw complicates the coronary atheromatous lesion in acute M1 was derived from autopsy studies and reported to vary from 13%-74%.' This disparity was doubtless due in part to the selection of the patient samples (sudden, early, late deaths), to types of infarctions (transmural, subendocardial), and to the methods of postmortem study (dissection or angiography). The prevailing hypothesis that a coronary thrombus was often seconduary to a MI was based, among other things, on the fact that at autopsy a thrombus was found more frequently in the older infarcts, after cardiac shock, or after severe heart failure.* The finding that radioactive fibrinogen, given in the acute phase of MI, has been recovered in the coronary thrombus at autopsy was wrongly conqidered as an argument in EWP stccring committee: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interventional Cardiology Wiley

Trials of the European Working Party on Streptokinase and of the European Cooperative Study Group on Alteplase in Patients with Acute Myocardial Infarction

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References (46)

Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0896-4327
eISSN
1540-8183
DOI
10.1111/j.1540-8183.1995.tb00910.x
Publisher site
See Article on Publisher Site

Abstract

Trials of the European Working Party on Streptokinase and of the European Cooperative Working Group on tPA in Patients with Acute Myocardial Infarction The first trial of the European Working Party was commenced in 1962 at a time when no controlled, strictly randomized, large scale trials on the clinical use of thrombolytic drugs in patients with recent myocardial infarction (MI) were available. At that time, the frequency with which a fresh thrombw complicates the coronary atheromatous lesion in acute M1 was derived from autopsy studies and reported to vary from 13%-74%.' This disparity was doubtless due in part to the selection of the patient samples (sudden, early, late deaths), to types of infarctions (transmural, subendocardial), and to the methods of postmortem study (dissection or angiography). The prevailing hypothesis that a coronary thrombus was often seconduary to a MI was based, among other things, on the fact that at autopsy a thrombus was found more frequently in the older infarcts, after cardiac shock, or after severe heart failure.* The finding that radioactive fibrinogen, given in the acute phase of MI, has been recovered in the coronary thrombus at autopsy was wrongly conqidered as an argument in EWP stccring committee:

Journal

Journal of Interventional CardiologyWiley

Published: Dec 1, 1995

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