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F. Giannelli, R. Howlett (1966)
The identification of the chromosomes of the D group (13-15) Denver: an autoradiographic and measurement study.Cytogenetics, 5 3
De Capoa De Capoa, Breg Breg, Kushnick Kushnick, Miller Miller (1968)
Radioautographic identification of the D chromosomes involved in the centric type of D/G translocationAnn. Hum. Genet., 32
F. Giannelli (1965)
Autoradiographic Identification of the D (13–15) Chromosome Responsible for D1 Trisomic Patau's SyndromeNature, 208
J. German (1964)
THE PATTERN OF DNA SYNTHESIS IN THE CHROMOSOMES OF HUMAN BLOOD CELLSThe Journal of Cell Biology, 20
JorgeJ. Yunis, ErnestB. Hook, Mary Mayer (1964)
DEOXYRIBONUCLEIC-ACID REPLICATION PATTERN OF TRISOMY D1.Lancet, 2 7366
(1967)
Trisomy D, in a 10 year old girl
Yunis Yunis, Hook Hook, Mayer Mayer (1964)
DNA replication pattern of trisomy D 1Lancet, ii
M. Mikkelsen (1967)
DNA replication analysis of six 13–15/21 translocation familiesAnnals of Human Genetics, 30
L. Dallaire, F. Fraser (1964)
TWO UNUSUAL CASES OF FAMILIAL MONGOLISM.Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie, 6
W. Schmid (1963)
DNA REPLICATION PATTERNS OF HUMAN CHROMOSOMES.Cytogenetics, 2
A. Capoa, W. Breg, T. Kushnick, O. Miller (1968)
Radioautographic identification of the D chromosomes involved in the centric fusion type of D/G translocation, t(DqGq)Annals of Human Genetics, 32
P. Marden, J. Yunis (1967)
Trisomy D1 in a 10-year-old girl. Normal neutrophils and fetal hemoglobin.American journal of diseases of children, 114 6
A. Capoa, O. Miller, B. Mukherjee, D. Warburton (1968)
Autoradiographic studies on a mother and aborted foetus from a family with four mongoloid children and a presumptive 21/21 translocationAnnals of Human Genetics, 31
There have been many reports of carriers of translocations of the centric fusion type, in which the carriers show no phenotypic abnormalities. I n most cases the chromosomes involved have not been the homologous members of the same pair, since normal children have been born to the carriers. In two families, however, in which only mongo1 children were born, the translocation was thought to be of pair no. 21 (Dallaire & Fraser, 1964; de Capoa et al. 1967). The present paper reports the case of a phenotypically normal woman with a D/D translocation who has had at least thirteen unsuccessful pregnancies all terminating before the Mteenth week, and no normal pregnancies. The translocation appears to involve both members of pair no. 15. CASE HISTORY The patient is an apparently normal woman of 37 who has had no serious illnesses. She was adopted as a baby so nothing is known of her family history. The menarche occurred at age 15 and her menstrual cycle is regular. She was married in 1955 and may have had an abortion in that year. I n 1956 three abortions occurred, two at 8 weeks and one at 12 weeks. In 1957 and 1958
Annals of Human Genetics – Wiley
Published: May 1, 1969
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