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Translocation between both members of chromosome pair number 15 causing recurrent abortions

Translocation between both members of chromosome pair number 15 causing recurrent abortions There have been many reports of carriers of translocations of the centric fusion type, in which the carriers show no phenotypic abnormalities. I n most cases the chromosomes involved have not been the homologous members of the same pair, since normal children have been born to the carriers. In two families, however, in which only mongo1 children were born, the translocation was thought to be of pair no. 21 (Dallaire & Fraser, 1964; de Capoa et al. 1967). The present paper reports the case of a phenotypically normal woman with a D/D translocation who has had at least thirteen unsuccessful pregnancies all terminating before the Mteenth week, and no normal pregnancies. The translocation appears to involve both members of pair no. 15. CASE HISTORY The patient is an apparently normal woman of 37 who has had no serious illnesses. She was adopted as a baby so nothing is known of her family history. The menarche occurred at age 15 and her menstrual cycle is regular. She was married in 1955 and may have had an abortion in that year. I n 1956 three abortions occurred, two at 8 weeks and one at 12 weeks. In 1957 and 1958 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Translocation between both members of chromosome pair number 15 causing recurrent abortions

Annals of Human Genetics , Volume 32 (4) – May 1, 1969

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References (13)

Publisher
Wiley
Copyright
Copyright © 1969 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1969.tb00085.x
Publisher site
See Article on Publisher Site

Abstract

There have been many reports of carriers of translocations of the centric fusion type, in which the carriers show no phenotypic abnormalities. I n most cases the chromosomes involved have not been the homologous members of the same pair, since normal children have been born to the carriers. In two families, however, in which only mongo1 children were born, the translocation was thought to be of pair no. 21 (Dallaire & Fraser, 1964; de Capoa et al. 1967). The present paper reports the case of a phenotypically normal woman with a D/D translocation who has had at least thirteen unsuccessful pregnancies all terminating before the Mteenth week, and no normal pregnancies. The translocation appears to involve both members of pair no. 15. CASE HISTORY The patient is an apparently normal woman of 37 who has had no serious illnesses. She was adopted as a baby so nothing is known of her family history. The menarche occurred at age 15 and her menstrual cycle is regular. She was married in 1955 and may have had an abortion in that year. I n 1956 three abortions occurred, two at 8 weeks and one at 12 weeks. In 1957 and 1958

Journal

Annals of Human GeneticsWiley

Published: May 1, 1969

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