Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Towards the Total Synthesis of Gedunin: Construction of the Fully Elaborated ABC Ring System

Towards the Total Synthesis of Gedunin: Construction of the Fully Elaborated ABC Ring System The widely occurring tetranortriterpene natural product gedunin has a well‐established range of important biological properties. Although this molecule has received substantial semi‐synthetic attention from medicinal chemists, it has not received devoted de novo synthetic attention since it was first isolated in 1960. A key feature of the approach presented herein was the decision to utilize a Robinson annulation reaction, which facilitated the installation of the challenging 7‐acetoxy functional group and the completion of the fully functionalized ABC ring system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Towards the Total Synthesis of Gedunin: Construction of the Fully Elaborated ABC Ring System

Loading next page...
 
/lp/wiley/towards-the-total-synthesis-of-gedunin-construction-of-the-fully-NxDmj6gu9K

References (75)

Publisher
Wiley
Copyright
© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201700013
Publisher site
See Article on Publisher Site

Abstract

The widely occurring tetranortriterpene natural product gedunin has a well‐established range of important biological properties. Although this molecule has received substantial semi‐synthetic attention from medicinal chemists, it has not received devoted de novo synthetic attention since it was first isolated in 1960. A key feature of the approach presented herein was the decision to utilize a Robinson annulation reaction, which facilitated the installation of the challenging 7‐acetoxy functional group and the completion of the fully functionalized ABC ring system.

Journal

Asian Journal of Organic ChemistryWiley

Published: May 1, 2017

Keywords: ; ; ; ;

There are no references for this article.