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Tissue distributions, substrate specificities and molecular sizes of human peptidases determined by separate gene loci

Tissue distributions, substrate specificities and molecular sizes of human peptidases determined... SUMMARY 1. The distribution of seven different peptidases thought to be determined by separate gene loci has been examined in a variety of human tissues. Although most of them are widely distributed, their relative activities vary from tissue to tissue. 2. The enzymes have been characterized in terms of their electrophoretie mobilities, their patterns of specificity with thirty‐five different substrates, and their molecular sizes as estimated by gel nitration. 3. One of the peptidases (peptidase S) which is not found in red cells but is present in most other tissues has not been previously described. It appears to hydrolyse a somewhat wider range of substrates than the other peptidases, and to have a larger molecular size (c. 245,000). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Tissue distributions, substrate specificities and molecular sizes of human peptidases determined by separate gene loci

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References (36)

Publisher
Wiley
Copyright
Copyright © 1971 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1971.tb00243.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY 1. The distribution of seven different peptidases thought to be determined by separate gene loci has been examined in a variety of human tissues. Although most of them are widely distributed, their relative activities vary from tissue to tissue. 2. The enzymes have been characterized in terms of their electrophoretie mobilities, their patterns of specificity with thirty‐five different substrates, and their molecular sizes as estimated by gel nitration. 3. One of the peptidases (peptidase S) which is not found in red cells but is present in most other tissues has not been previously described. It appears to hydrolyse a somewhat wider range of substrates than the other peptidases, and to have a larger molecular size (c. 245,000).

Journal

Annals of Human GeneticsWiley

Published: Feb 1, 1971

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