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K. Lange, M. Spence, M. Frank (1976)
Application of the lod method to the detection of linkage between a quantitative trait and a qualitative marker: a simulation experiment.American journal of human genetics, 28 2
S. Daiger, M. Miller, R. Chakraborty (1984)
Heritability of quantitative variation at the group-specific component (Gc) locus.American journal of human genetics, 36 3
Eric Boerwinkle, Charles Sing (1986)
Bias of the contribution of single-locus effects to the variance of a quantitative trait.American journal of human genetics, 39 1
C. Maclean, N. Morton, R. Lew (1975)
Analysis of family resemblance. IV. Operational characteristics of segregation analysis.American journal of human genetics, 27 3
N. Morton, C. Maclean (1974)
Analysis of family resemblance. 3. Complex segregation of quantitative traits.American journal of human genetics, 26 4
A. Jacquard (1974)
The Genetic Structure of Populations
R. Go, R. Elston, E. Kaplan (1978)
Efficiency and robustness of pedigree segregation analysis.American journal of human genetics, 30 1
R. Clark, E. Boerwinkle, G. Brewer, C. Sing (1983)
Studies of enzyme polymorphism in the Kamuela population of Drosophila mercatorum. III. Effects of variation at the alpha GPD locus and subflight stress on the energy charge and glycolytic intermediate concentrations.Genetics, 104 4
N. Day (1969)
Estimating the components of a mixture of normal distributionsBiometrika, 56
T. Burns, P. Moll, M. Schork (1984)
Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits.American journal of human genetics, 36 5
Leonard Langer, S. Yang, J. Hall, Annemarie Sommer, Sambasiva Kottamasu, Mahin Golabi, Natalie Krassikoff, John Opitz, Jay Bernstein (1987)
Thanatophoric dysplasia and cloverleaf skull.American journal of medical genetics. Supplement, 3
C. Sing, J. Orr (1976)
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. III. Identification of genetic effects using 12 polymorphic genetic blood marker systems.American journal of human genetics, 28 5
J. Hopper, J. Mathews (1982)
Extensions to multivariate normal models for pedigree analysisAnnals of Human Genetics, 46
R. Elston, James Stewart (1971)
A general model for the genetic analysis of pedigree data.Human heredity, 21 6
V. Hasselblad (1966)
Estimation of parameters for a mixture of normal distributionsTechnometrics, 8
S. Turner, Mark Johnson, E. Boerwinkle, E. Richelson, H. Taswell, C. Sing, S. Turner, M. Johnson, E. Richelson, H. Taswell, Ann Arbor, Michigan, E. Boerwinkle, C. Sing
Sodium-lithium Countertransport and Blood Pressure in Healthy Blood Donors Summary Studies Finding an Increased Maximal Rate of Na-li Countertransport in Red Blood Cells from Persons with Essential Hypertension and Their Normotensive Offspring Have Raised the Possibility That Na-li Countertransport
W. Blackwelder, R. Elston (1974)
Comment on Dr. Robertson's communicationBehavior Genetics, 4
C. Li, L. Sacks (1954)
The Derivation of Joint Distribution and Correlation between Relatives by the Use of Stochastic MatricesBiometrics, 10
D. Hopkinson, N. Spencer, H. Harris (1964)
GENETICAL STUDIES ON HUMAN RED CELL ACID PHOSPHATASE.American journal of human genetics, 16
M. Kutner (1975)
Applied Linear Statistical Models
K. Lange, J. Westlake, M. Spence (1976)
Extensions to pedigree analysis III. Variance components by the scoring methodAnnals of Human Genetics, 39
Cedric Smith (1980)
Estimating genetic correlationsAnnals of Human Genetics, 43
Morton Morton, MacLean MacLean (1974)
Analysis of family resemblance. III. Complex segregation analysis of quantitative traitsAm. J. Hum. Genet., 26
James Thompson (1975)
Quantitative variation and gene numberNature, 258
James Thompson, J. Thoday (1979)
SYNTHESIS: POLYGENIC VARIATION IN PERSPECTIVE
H. Scheffé (1960)
The Analysis of Variance
J. Lalouel, D. Rao, N. Morton, R. Elston (1983)
A unified model for complex segregation analysis.American journal of human genetics, 35 5
Sing Sing, Davignon Davignon (1985)
The role of Apoliprotein E genetic polymorphism in determining normal plasma lipid and lipoprotein variationAm. J. Hum. Gen., 37
R. Fisher
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.Transactions of the Royal Society of Edinburgh, 52
P. Moll, T. Berry, W. Weidman, R. Ellefson, H. Gordon, B. Kottke (1984)
Detection of genetic heterogeneity among pedigrees through complex segregation analysis: an application to hypercholesterolemia.American journal of human genetics, 36 1
A. Neimann-Sørensen, A. Robertson (1961)
The Association between Blood Groups and Several Production Characteristics in Three Danish Cattle BreedsActa Agriculturae Scandinavica, 11
A. Wyman, Ray WHITEt (1980)
A highly polymorphic locus in human DNA.Proceedings of the National Academy of Sciences of the United States of America, 77 11
C. Sing, J. Davignon (1985)
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation.American journal of human genetics, 37 2
E. Boerwinkle, S. Turner, C. Sing (1984)
The role of the genetics of sodium lithium countertransport in the determination of blood pressure variability in the population at large.Progress in clinical and biological research, 165
J. Goldstein, M. Brown (1979)
The LDL receptor locus and the genetics of familial hypercholesterolemia.Annual review of genetics, 13
Blackwelder Blackwelder, Elston Elston (1974)
Comments on dr. Robinson's communicationBehavioral Genetics, 4
Dempster Dempster, Laird Laird, Rubin Rubin (1977)
Maximum likelihood for incomplete data via the EM algorithmJ. Roy. Stal. Soc. B, 39
P. Moll, Rachel Powsner, C. Sing (1979)
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. V. Variance components estimated from pedigreesAnnals of Human Genetics, 42
J. Lalouel, P. Darlu, J. Henrotte, D. Rao (1983)
Genetic regulation of plasma and red blood cell magnesium concentration in man. II. Segregation analysis.American journal of human genetics, 35 5
Summary Improved laboratory methods allow one to investigate the contribution of measured allelic variability at a locus physiologically involved in determining the expression of a quantitative trait. We present statistical methods that incorporate measured genotype information into the analysis of a quantitative phenotype that allows one simultaneously to detect and estimate the effects of a measured single locus and residual polygenic effects. Likelihoods are presented for the joint distribution of the quantitative phenotype and a measured genotype that are appropriate when the data are collected as a sample of unrelated individuals or as a sample of nuclear families. Application of this method to the analysis of serum cholesterol levels and the concentration of the group specific component (Gc) are presented. The analysis of the contribution of the common Gc polymorphism to the determination of quantitative variability in Gc using smaples of related and unrelated individuals presents, for the first time, the simultaneous estimation of the frequencies and the effects of the genotypes at a measured locus, and the contribution of residual unmeasured polygenes to phenotypic variability.
Annals of Human Genetics – Wiley
Published: May 1, 1986
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