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The therapeutic index of antihistamines

The therapeutic index of antihistamines The therapeutic index of antihistamines Church MK. The therapeutic index of antihistamines. Pediatr Allergy Immunol 1993: 4 (suppl 4): 25-32. 0Munksgaard 1993. M. K. Church Clinical Pharmacology Group, Southampton General Hospital, United Kingdom Professor M. K. Church, Clinical Pharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton SO9 4XY, United Kingdom Key words: therapeutic index; antihistamine Allergic diseases comprise a spectrum of pathological conditions that share a common initiation, namely the combination of allergen with cell bound immunoglobulin E (IgE); they have a remarkably similar cellular pathology and yet their symptoms vary considerably with the nature of the target organ. As both symptomatic control and treatment of the underlying development of chronic allergic inflammation should be the aims of therapy, it is pertinent to present a brief summary of the mechanisms of allergic disease in different organs before discussing drug therapy. In all time-extrinsic allergic diseases, the primary event is the sensitization of individuals to specific allergens. In all atopic individuals, i.e., those with a genetic predisposition to allergy, contact with allergens, such as products of the house dust mite, Dermatophagoides pteronyssinus, or grass pollens, gives rise to a cognate relationship between antigen-presenting cells (APC), T-lymphocytes and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

The therapeutic index of antihistamines

Church, M. K.
Pediatric Allergy and Immunology , Volume 4 (S4) – Dec 1, 1993
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References (120)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1993.tb00335.x
Publisher site
See Article on Publisher Site

Abstract

The therapeutic index of antihistamines Church MK. The therapeutic index of antihistamines. Pediatr Allergy Immunol 1993: 4 (suppl 4): 25-32. 0Munksgaard 1993. M. K. Church Clinical Pharmacology Group, Southampton General Hospital, United Kingdom Professor M. K. Church, Clinical Pharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton SO9 4XY, United Kingdom Key words: therapeutic index; antihistamine Allergic diseases comprise a spectrum of pathological conditions that share a common initiation, namely the combination of allergen with cell bound immunoglobulin E (IgE); they have a remarkably similar cellular pathology and yet their symptoms vary considerably with the nature of the target organ. As both symptomatic control and treatment of the underlying development of chronic allergic inflammation should be the aims of therapy, it is pertinent to present a brief summary of the mechanisms of allergic disease in different organs before discussing drug therapy. In all time-extrinsic allergic diseases, the primary event is the sensitization of individuals to specific allergens. In all atopic individuals, i.e., those with a genetic predisposition to allergy, contact with allergens, such as products of the house dust mite, Dermatophagoides pteronyssinus, or grass pollens, gives rise to a cognate relationship between antigen-presenting cells (APC), T-lymphocytes and

Journal

Pediatric Allergy and Immunology – Wiley

Published: Dec 1, 1993

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