Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The testing of dominants for heterozygosity

The testing of dominants for heterozygosity The testing of dominants for heterozygosity BY C . C . L I Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Consider a pair of autosomal genes with gene G dominant over gene g. Animal and plant breeders have always used some type of 'progeny tests' to distinguish the homozygous dominants (GG) from the heterozygous dominants (Gg). The plant breeders usually have no difficulty in doing this, as each test-mating yields a large number of offspring. For mammals, especially large animals, however, the results of test mating are not always clear-cut because of the limited number of offspring produced by each mating. A heterozygous dominant producing all dominant offspringmay be mistaken for a homozygous dominant. A fundamental paper on the subject of test mating, mis-classification, and correction is the pioneer work of Haldane (1938). Unfortunately, there are a number of obscurities in that paper that have puzzled human genetics students who tried to apply the method. The present communication attempts to clarify some of the obscure points, and I am sure that the late Professor Haldane would have liked to see this done. In this note the original notation has been followed without any modification. To make http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

The testing of dominants for heterozygosity

LI, C. C.
Annals of Human Genetics , Volume 40 (2) – Nov 1, 1976
Download PDF
8 pages

Loading next page...
 
/lp/wiley/the-testing-of-dominants-for-heterozygosity-5UtG7EIEm8

References (3)

Publisher
Wiley
Copyright
Copyright © 1976 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1976.tb00178.x
Publisher site
See Article on Publisher Site

Abstract

The testing of dominants for heterozygosity BY C . C . L I Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Consider a pair of autosomal genes with gene G dominant over gene g. Animal and plant breeders have always used some type of 'progeny tests' to distinguish the homozygous dominants (GG) from the heterozygous dominants (Gg). The plant breeders usually have no difficulty in doing this, as each test-mating yields a large number of offspring. For mammals, especially large animals, however, the results of test mating are not always clear-cut because of the limited number of offspring produced by each mating. A heterozygous dominant producing all dominant offspringmay be mistaken for a homozygous dominant. A fundamental paper on the subject of test mating, mis-classification, and correction is the pioneer work of Haldane (1938). Unfortunately, there are a number of obscurities in that paper that have puzzled human genetics students who tried to apply the method. The present communication attempts to clarify some of the obscure points, and I am sure that the late Professor Haldane would have liked to see this done. In this note the original notation has been followed without any modification. To make

Journal

Annals of Human Genetics – Wiley

Published: Nov 1, 1976

There are no references for this article.