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J. Sui, Wenhui Li, A. Murakami, A. Tamin, Leslie Matthews, S. Wong, M. Moore, A. Tallarico, Mobolaji Olurinde, H. Choe, L. Anderson, W. Bellini, M. Farzan, W. Marasco (2004)
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association.Proceedings of the National Academy of Sciences of the United States of America, 101 8
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Li-Rung Chen, Yu-Chin Wang, Y. Lin, S. Chou, Shyh-Fong Chen, L. Liu, Ying-Ta Wu, C. Kuo, T. Chen, S. Juang (2005)
Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitorsBioorganic & Medicinal Chemistry Letters, 15
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E. Snijder, P. Bredenbeek, J. Dobbe, V. Thiel, J. Ziebuhr, L. Poon, Y. Guan, M. Rozanov, W. Spaan, A. Gorbalenya (2003)
Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 LineageJournal of Molecular Biology, 331
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J. Joseph, K. Saikatendu, V. Subramanian, B. Neuman, A. Brooun, Mark Griffith, K. Moy, M. Yadav, Jeff Velasquez, M. Buchmeier, R. Stevens, P. Kuhn (2006)
Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding MotifsJournal of Virology, 80
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K. Saikatendu, J. Joseph, V. Subramanian, T. Clayton, Mark Griffith, K. Moy, Jeff Velasquez, B. Neuman, M. Buchmeier, R. Stevens, P. Kuhn (2005)
Structural Basis of Severe Acute Respiratory Syndrome Coronavirus ADP-Ribose-1″-Phosphate Dephosphorylation by a Conserved Domain of nsP3Structure (London, England : 1993), 13
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Erik Prentice, J. McAuliffe, Xiaotao Lu, K. Subbarao, M. Denison (2004)
Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Replicase ProteinsJournal of Virology, 78
- Publisher
- Wiley
- Copyright
- Copyright © 2008 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0108-7673
- eISSN
- 1600-5724
- DOI
- 10.1107/S0108767307054426
- pmid
- 18156685
- Publisher site
- See Article on Publisher Site
Abstract
The 2003 outbreak of severe acute respiratory syndrome (SARS), caused by a previously unknown coronavirus called SARS‐CoV, had profound social and economic impacts worldwide. Since then, structure–function studies of SARS‐CoV proteins have provided a wealth of information that increases our understanding of the underlying mechanisms of SARS. While no effective therapy is currently available, considerable efforts have been made to develop vaccines and drugs to prevent SARS‐CoV infection. In this review, some of the notable achievements made by SARS structural biology projects worldwide are examined and strategies for therapeutic intervention are discussed based on available SARS‐CoV protein structures. To date, 12 structures have been determined by X‐ray crystallography or NMR from the 28 proteins encoded by SARS‐CoV. One key protein, the SARS‐CoV main protease (Mpro), has been the focus of considerable structure‐based drug discovery efforts. This article highlights the importance of structural biology and shows that structures for drug design can be rapidly determined in the event of an emerging infectious disease.
Journal
Acta Crystallographica Section A: Foundations and Advances – Wiley
Published: Jan 1, 2008
Keywords: ; ;