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Copyright ISBN 67-16-15126-7 ISSN 0906-5783 The role of air pollutants Nilsson L. The role of air pollutants. Pediatr Allergy Immunol 1994: 5 (Suppl 1): 52-56. 0Munksgaard 1994. Lennart Nilsson University Hospital, LinkBping, Sweden Faculty of Health Sciences, Institution of Pediatrics, University Hospital, S-58185 Linkoping, Sweden The immune response Normally, rats, who have been exposed to allergens during the first weeks of life will show a tolerance to the antigen after a brief IgE antibody response (1). We can also see this in infants (2). When the individual, at the time of initial exposure to an antigen, is simultaneously exposed to certain risk factors, the immune response may instead steadily increase. This expands the pool of memory T cells and this effectively primes the immune system. You will have then built a foundation of hypersensitivity to the allergen. Once an allergic inflammatory response to an allergen occurs, the process in turn enhances sensitization to new allergens. Different air pollutants (Diesel exhaust, SO2, NOz and ozone) Interplay If we have an individual with a genetic propensity to allergy, the allergic disease is the result of an interplay between exposure to the allergen and various environmental influences. The susceptibility to sensitization
Pediatric Allergy and Immunology – Wiley
Published: May 1, 1994
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