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Sarah Ruediger, D. Spirig, F. Donato, P. Caroni (2012)
Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learningNature Neuroscience, 15
S. Lea (1981)
Contemporary Animal Learning Theory, Anthony Dickinson. Cambridge University Press, Cambridge (1981), xii, +177 pp. £12.50 hardback, £3.95 paperbackAnimal Behaviour, 29
Amar Sahay, Kimberly Scobie, Alexis Hill, C. O’Carroll, M. Kheirbek, N. Burghardt, A. Fenton, A. Dranovsky, R. Hen (2011)
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separationNature, 472
M. Llorens-Martín, I. Torres-Alemán, J. Trejo (2006)
Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neuronsHippocampus, 16
D. Dupret, Annabelle Fabre, M. Döbrössy, A. Panatier, Jose Rodriguez, S. Lamarque, V. Lemaire, S. Oliet, P. Piazza, D. Abrous (2007)
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal NeuronsPLoS Biology, 5
Carmen Vivar, H. Praag (2013)
Functional circuits of new neurons in the dentate gyrusFrontiers in Neural Circuits, 7
F. Fumagalli, M. Pasini, A. Frasca, F. Drago, G. Racagni, M. Riva (2009)
Prenatal stress alters glutamatergic system responsiveness in adult rat prefrontal cortexJournal of Neurochemistry, 109
M. Trinchero, M. Koehl, Malik Bechakra, P. Delage, V. Charrier, Noëlle Grosjean, E. Ladevèze, A. Schinder, D. Abrous (2015)
Effects of spaced learning in the water maze on development of dentate granule cells generated in adult miceHippocampus, 25
(2011)
Adult Neurogenesis 2
A. Amsel (1992)
Frustration theory--many years later.Psychological bulletin, 112 3
S. Tronel, Laure Belnoue, Noëlle Grosjean, J. Revest, P. Piazza, M. Koehl, D. Abrous (2012)
Adult‐born neurons are necessary for extended contextual discriminationHippocampus, 22
R. Miltenberger (1996)
Behavior Modification: Principles and Procedures
L. Raine, H. Lee, Brian Saliba, Laura Chaddock-Heyman, C. Hillman, A. Kramer (2013)
The Influence of Childhood Aerobic Fitness on Learning and MemoryPLoS ONE, 8
James Groves, I. Leslie, Guo-Jen Huang, S. McHugh, Amy Taylor, R. Mott, M. Munafo, D. Bannerman, J. Flint (2013)
Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic ModelPLoS Genetics, 9
Carmen Vivar, M. Potter, Jiwon Choi, Ji-young Lee, T. Stringer, E. Callaway, F. Gage, Hoonkyo Suh, H. Praag (2012)
Monosynaptic inputs to new neurons in the dentate gyrusNature Communications, 3
M. Llorens-Martín, G. Tejeda, J. Trejo (2011)
Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs RecoveryNeuropsychopharmacology, 36
A. Garthe, J. Behr, G. Kempermann (2009)
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning StrategiesPLoS ONE, 4
D. Lerman, Brian Iwata (1995)
Prevalence of the extinction burst and its attenuation during treatment.Journal of applied behavior analysis, 28 1
Yung‐Wei Pan, G. Chan, C. Kuo, D. Storm, Z. Xia (2012)
Inhibition of Adult Neurogenesis by Inducible and Targeted Deletion of ERK5 Mitogen-Activated Protein Kinase Specifically in Adult Neurogenic Regions Impairs Contextual Fear Extinction and Remote Fear MemoryThe Journal of Neuroscience, 32
A. Garthe, G. Kempermann (2013)
An old test for new neurons: refining the Morris water maze to study the functional relevance of adult hippocampal neurogenesisFrontiers in Neuroscience, 7
M. Llorens-Martín, G. Tejeda, J. Trejo (2010)
Differential Regulation of the Variations Induced by Environmental Richness in Adult Neurogenesis as a Function of Time: A Dual Birthdating AnalysisPLoS ONE, 5
A. Dickinson (1980)
Contemporary Animal Learning Theory
Yung‐Wei Pan, D. Storm, Z. Xia (2013)
Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: New insights from ERK5 MAP kinaseNeurobiology of Learning and Memory, 105
M. Llorens-Martín, N. Rueda, C. Martínez-Cué, I. Torres-Alemán, J. Flórez, José Trejo (2007)
Both increases in immature dentate neuron number and decreases of immobility time in the forced swim test occurred in parallel after environmental enrichment of miceNeuroscience, 147
P. Pérez-Domper, Simona Gradari, J. Trejo (2013)
The growth factors cascade and the dendrito-/synapto-genesis versus cell survival in adult hippocampal neurogenesis: The chicken or the eggAgeing Research Reviews, 12
J. Vukovic, G. Borlikova, M. Ruitenberg, GregoryJ Robinson, R. Sullivan, T. Walker, P. Bartlett (2013)
Immature Doublecortin-Positive Hippocampal Neurons Are Important for Learning But Not for RememberingThe Journal of Neuroscience, 33
A. Bilang‐Bleuel, J. Rech, S. Carli, F. Holsboer, J. Reul (2002)
Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the ratEuropean Journal of Neuroscience, 15
A. Tashiro, Hiroshi Makino, F. Gage (2007)
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature StageThe Journal of Neuroscience, 27
A. Garthe, Z. Huang, Leszek Kaczmarek, R. Filipkowski, Gerd Kempermann (2014)
Not all water mazes are created equal: cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficitsGenes, Brain, and Behavior, 13
B. Skinner (1974)
Behavior modification.Science, 185 4154
Benjamin Lacar, Sarah Parylak, K. Vadodaria, Anindita Sarkar, Fred Gage (2014)
Increasing the resolution of the adult neurogenesis pictureF1000Prime Reports, 6
J. Barker, J. Wojtowicz, R. Boonstra (2004)
Where's my dinner? Adult neurogenesis in free‐living food‐storing rodentsGenes, 4
L. Garcia-Segura (2009)
Hormones and Brain Plasticity
J. Aimone, Wei Deng, F. Gage (2011)
Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern SeparationNeuron, 70
Julia Freund, A. Brandmaier, Lars Lewejohann, Imke Kirste, Mareike Kritzler, Antonio Krüger, Norbert Sachser, U. Lindenberger, Gerd Kempermann (2013)
Emergence of Individuality in Genetically Identical MiceScience, 340
Changpeng Shen, Y. Tsimberg, Christopher Salvadore, E. Meller (2004)
Activation of Erk and JNK MAPK pathways by acute swim stress in rat brain regionsBMC Neuroscience, 5
E. Castrén, R. Hen (2013)
Neuronal plasticity and antidepressant actionsTrends in Neurosciences, 36
T. Nakashiba, J. Cushman, K. Pelkey, S. Renaudineau, D. Buhl, T. McHugh, V. Barrera, R. Chittajallu, Keisuke Iwamoto, C. McBain, M. Fanselow, S. Tonegawa (2012)
Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern CompletionCell, 149
J. Gil-Mohapel, P. Brocardo, Will Choquette, Russ Gothard, J. Simpson, B. Christie (2013)
Hippocampal Neurogenesis Levels Predict WATERMAZE Search Strategies in the Aging BrainPLoS ONE, 8
ABSTRACT The influence of the learning process on the persistence of the newly acquired behavior is relevant both for our knowledge of the learning/memory mechanisms and for the educational policy. However, it is unclear whether during an operant conditioning process with a continuous reinforcement paradigm, individual differences in acquisition are also associated to differences in persistence of the acquired behavior. In parallel, adult neurogenesis has been implicated in spatial learning and memory, but the specific role of the immature neurons born in the adult brain is not well known for this process. We have addressed both questions by analyzing the relationship between water maze task acquisition scores, the persistence of the acquired behavior, and the size of the different subpopulations of immature neurons in the adult murine hippocampus. We have found that task acquisition and persistence rates were negatively correlated: the faster the animals find the water maze platform at the end of acquisition stage, the less they persist in searching for it at the learned position in a subsequent non‐reinforced trial; accordingly, the correlation in the number of some new neurons' subpopulations and the acquisition rate is negative while with persistence in acquired behavior is positive. These findings reveal an unexpected relationship between the efficiency to learn a task and the persistence of the new behavior after a non‐reinforcement paradigm, and suggest that the immature neurons might be involved in different roles in acquisition and persistence/extinction of a learning task. © 2016 Wiley Periodicals, Inc.
Hippocampus – Wiley
Published: Jul 1, 2016
Keywords: ; ; ; ;
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