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J. Newton, S. Harney, B. Wordsworth, MA Brown (2004)
A review of the MHC genetics of rheumatoid arthritisGenes and Immunity, 5
Ming Li, S. Erickson, C. Hobbs, Jingyun Li, Xinyu Tang, Todd Nick, S. Macleod, M. Cleves (2014)
Detecting Maternal‐Fetal Genotype Interactions Associated With Conotruncal Heart Defects: A Haplotype‐Based Analysis With Penalized Logistic RegressionGenetic Epidemiology, 38
B. Mitchell, C. Kammerer, J. Blangero, M. Mahaney, D. Rainwater, B. Dyke, J. Hixson, R. Henkel, R. Sharp, Anthony Comuzzie, J. VandeBerg, M. Stern, J. Maccluer (1996)
Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study.Circulation, 94 9
J. Sinsheimer, Michelle Creek (2013)
Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans
Y. Lee, Yasuyo Daito, Y. Katayama, H. Minami, H. Negishi (2009)
The significance of measurement of serum unbound bilirubin concentrations in high‐risk infantsPediatrics International, 51
P. Gregersen, J. Silver, R. Winchester (1987)
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.Arthritis and rheumatism, 30 11
M. Cannon, Peter Jones, R. Murray (2002)
Obstetric complications and schizophrenia: historical and meta-analytic review.The American journal of psychiatry, 159 7
S. Harney, J. Newton, A. Milicic, M. Brown, Bryan Wordsworth (2003)
Non-inherited maternal HLA alleles are associated with rheumatoid arthritis.Rheumatology, 42 1
Tristan Hayeck, N. Zaitlen, Po-ru Loh, B. Vilhjálmsson, Samuela Pollack, A. Gusev, Jian Yang, Guo-Bo Chen, M. Goddard, P. Visscher, N. Patterson, A. Price (2014)
Mixed Model with Correction for Case-Control Ascertainment Increases Association PowerbioRxiv
B. Insel, Alan Brown, M. Bresnahan, C. Schaefer, E. Susser (2005)
Maternal–fetal blood incompatibility and the risk of schizophrenia in offspringSchizophrenia Research, 80
D. Jawaheer, P. Gregersen (2002)
Rheumatoid arthritis. The genetic components.Rheumatic diseases clinics of North America, 28 1
D. Schaid (1999)
Mathematical and Statistical Methods for Genetic AnalysisAmerican Journal of Human Genetics, 64
K. Lange, J. Papp, J. Sinsheimer, Ram Sripracha, Hua Zhou, E. Sobel (2013)
Mendel: the Swiss army knife of genetic analysis programsBioinformatics, 29 12
D. Freedman, R. Deicken, L. Kegeles, S. Vinogradov, Yuanyuan Bao, Alan Brown (2011)
Maternal–fetal blood incompatibility and neuromorphologic anomalies in schizophrenia: Preliminary findingsProgress in Neuro-Psychopharmacology and Biological Psychiatry, 35
B. Devlin, K. Roeder (1999)
Genomic Control for Association StudiesBiometrics, 55
Wei-Min Chen, G. Abecasis (2007)
Family-based association tests for genomewide association scans.American journal of human genetics, 81 5
K. Lange, J. Sinsheimer (2005)
The Pedigree Trimming ProblemHuman Heredity, 58
H. Visser, S. Cessie, K. Vos, F. Breedveld, J. Hazes (2002)
How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis.Arthritis and rheumatism, 46 2
P. Lupo, L. Mitchell, M. Canfield, G. Shaw, A. Olshan, R. Finnell, Huiping Zhu (2014)
Maternal-fetal metabolic gene-gene interactions and risk of neural tube defects.Molecular genetics and metabolism, 111 1
M. Liang, Xun Wang, Jin Li, Fan Yang, Z. Fang, Li-hua Wang, Yonghua Hu, Dafang Chen (2010)
Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction StudyJournal of Biomedicine and Biotechnology, 2010
J. Fox (2008)
Applied Regression Analysis and Generalized Linear Models
Mitchell Mitchell, Kammerer Kammerer, Blangero Blangero, Mahaney Mahaney, Rainwater Rainwater, Dyke Dyke, Hixson Hixson, Henkel Henkel, Sharp Sharp, Comuzzie Comuzzie, Vandeberg Vandeberg, Stern Stern, Maccluer Maccluer (1996)
Genetic and environmental contributions to cardiovascular risk factors in Mexican AmericansThe San Antonio Family Heart Study. Circulation, 94
I. Silveira, R. Burlingame, C. Muhlen, A. Bender, H. Staub (2007)
Anti-CCP antibodies have more diagnostic impact than rheumatoid factor (RF) in a population tested for RFClinical Rheumatology, 26
K. Ayers, K. Lange (2008)
Penalized estimation of haplotype frequenciesBioinformatics, 24 14
D. Falconer (1965)
The inheritance of liability to certain diseases, estimated from the incidence among relativesAnnals of Human Genetics, 29
Naya Juul-Dam, J. Townsend, E. Courchesne (2001)
Prenatal, Perinatal, and Neonatal Factors in Autism, Pervasive Developmental Disorder-Not Otherwise Specified, and the General PopulationPediatrics, 107
C. Werning (1983)
[Rheumatoid arthritis].Medizinische Monatsschrift fur Pharmazeuten, 6 12
C. Palmer, E. Mallery, J. Turunen, Hsin-ju Hsieh, L. Peltonen, J. Lonnqvist, J. Woodward, J. Sinsheimer (2008)
Effect of Rhesus D incompatibility on schizophrenia depends on offspring sexSchizophrenia research, 104
M. Sáez, A. Gonzáléz-Pérez, M. Martínez-Larrad, J. Gayán, L. Real, M. Serrano-Ríos, A. Ruíz (2010)
WWOX gene is associated with HDL cholesterol and triglyceride levelsBMC Medical Genetics, 11
I. Horst-Bruinsma, J. Hazes, G. Schreuder, T. Radstake, P. Barrera, L. Putte, D. Mustamu, D. Schaardenburg, F. Breedveld, R. Vries (1998)
Influence of non-inherited maternal HLA-DR antigens on susceptibility to rheumatoid arthritisAnnals of the Rheumatic Diseases, 57
C. Palmer, J. Turunen, J. Sinsheimer, S. Minassian, T. Paunio, J. Lönnqvist, L. Peltonen, J. Woodward (2002)
RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility.American journal of human genetics, 71 6
(2017)
Author manuscript; available in PMC
Jian Yang, N. Zaitlen, M. Goddard, P. Visscher, A. Price (2014)
Advantages and pitfalls in the application of mixed-model association methodsNature Genetics, 46
E. Stubbs, E. Ritvo, A. Mason-Brothers (1985)
Autism and shared parental HLA antigens.Journal of the American Academy of Child Psychiatry, 24 2
J. Hollister, P. Laing, S. Mednick (1996)
Rhesus incompatibility as a risk factor for schizophrenia in male adults.Archives of general psychiatry, 53 1
Y. Benjamini, Y. Hochberg (1995)
Controlling the false discovery rate: a practical and powerful approach to multiple testingJournal of the royal statistical society series b-methodological, 57
P. Kraft, C. Palmer, Arthur Woodward, J. Turunen, S. Minassian, T. Paunio, J. Lönnqvist, L. Peltonen, J. Sinsheimer (2004)
RHD maternal–fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth orderEuropean Journal of Human Genetics, 12
E. Kistner, C. Weinberg (2005)
A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parentsGenetic Epidemiology, 29
E. Wheeler, H. Cordell (2007)
Quantitative trait association in parent offspring trios: Extension of case/pseudocontrol method and comparison of prospective and retrospective approachesGenetic Epidemiology, 31
Hua Zhou, J. Blangero, T. Dyer, K. Chan, K. Lange, E. Sobel (2014)
Fast Genome‐Wide QTL Association Mapping on Pedigree and Population DataGenetic Epidemiology, 41
E. Kistner, C. Weinberg (2004)
Method for using complete and incomplete trios to identify genes related to a quantitative traitGenetic Epidemiology, 27
Boerwinkle (1986)
The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methodsAnn Hum Genet, 50
L. Procopciuc, G. Caracostea, G. Zaharie, F. Stamatian (2014)
Maternal/newborn VEGF-C936T interaction and its influence on the risk, severity and prognosis of preeclampsia, as well as on the maternal angiogenic profileThe Journal of Maternal-Fetal & Neonatal Medicine, 27
Jenny Lee, D. Weissglas-Volkov, M. Kyttälä, Z. Dastani, R. Cantor, E. Sobel, Christopher Plaisier, J. Engert, M. Greevenbroek, J. Kane, M. Malloy, C. Pullinger, A. Huertas-Vazquez, C. Aguilar-Salinas, Teresa Tusié-Luna, T. Bruin, B. Aouizerat, C. Kallen, C. Croce, R. Aqeilan, M. Marcil, J. Viikari, T. Lehtimäki, O. Raitakari, J. Kuusisto, M. Laakso, M. Taskinen, J. Genest, P. Pajukanta (2008)
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.American journal of human genetics, 83 2
E. Boerwinkle, C. Sing (1987)
The use of measured genotype information in the analysis of quantitative phenotypes in man.Annals of Human Genetics, 51
P. Levine, L. Burnham, E. Katzin, P. Vogel (1941)
The role of iso-immunization in the pathogenesis of erythroblastosis fetalisAmerican Journal of Obstetrics and Gynecology, 42
G. Dahlquist, Christopher Patterson, G. Soltész (1999)
Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group.Diabetes care, 22 10
E. Dempster, I. Lerner (1950)
Heritability of Threshold Characters.Genetics, 35 2
SUMMARY Maternal‐offspring gene interactions, aka maternal‐fetal genotype (MFG) incompatibilities, are neglected in complex diseases and quantitative trait studies. They are implicated in birth to adult onset diseases but there are limited ways to investigate their influence on quantitative traits. We present the quantitative‐MFG (QMFG) test, a linear mixed model where maternal and offspring genotypes are fixed effects and residual correlations between family members are random effects. The QMFG handles families of any size, common or general scenarios of MFG incompatibility, and additional covariates. We develop likelihood ratio tests (LRTs) and rapid score tests and show they provide correct inference. In addition, the LRT's alternative model provides unbiased parameter estimates. We show that testing the association of SNPs by fitting a standard model, which only considers the offspring genotypes, has very low power or can lead to incorrect conclusions. We also show that offspring genetic effects are missed if the MFG modeling assumptions are too restrictive. With genome‐wide association study data from the San Antonio Family Heart Study, we demonstrate that the QMFG score test is an effective and rapid screening tool. The QMFG test therefore has important potential to identify pathways of complex diseases for which the genetic etiology remains to be discovered.
Annals of Human Genetics – Wiley
Published: Jan 1, 2016
Keywords: ; ; ; ; ; ; ; ;
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