Access the full text.
Sign up today, get DeepDyve free for 14 days.
Goodwin Ah, D. Cooper, A. Malcolm, Ippolito Rm, E. Koren, F. Neethling, Y. Ye, N. Zuhdi, Lamontagne Lr (1992)
Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans.Transplantation proceedings, 24 2
M. Slapak, M. Greenbaum, W. Bardawil, C. Saravis, J. Joison, W. McDermott (1971)
Effect of heparin, arvin, liver perfusion, and heterologous antiplatelet serum on rejection of pig kidney by dog.Transplantation proceedings, 3 1
Orthotopic heart
(1998)
Removal of antiporcine natural antibodies from huma and nonhuman primate plasma in vitro and in vivo by a Gala1±3Galb1± 4Glc-X immunoaf®nity column
A. Zaidi, M. Schmoeckel, F. Bhatti, P. Waterworth, M. Tolan, E. Cozzi, G. Chavez, G. Langford, S. Thiru, J. Wallwork, D. White, P. Friend (1998)
Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors.Transplantation, 65 12
M. Kimikawa, T. Kawai, D. Sachs, R. Colvin, A. Bartholomew, A. Cosimi (1997)
Mixed chimerism and transplantation tolerance induced by a nonlethal preparative regimen in cynomolgus monkeys.Transplantation proceedings, 29 1-2
(1994)
XU H, et al
(1971)
GERWURZ H, et al
Stanley Jordan, D. Tyan, L. Czer, M. Toyoda (1998)
Immunomodulatory actions of intravenous immunoglobulin (IVIG): potential applications in solid organ transplant recipients.Pediatric transplantation, 2 2
U. Galili, D. LaTemple, A. Walgenbach, K. Stone (1997)
Porcine and bovine cartilage transplants in cynomolgus monkey: II. Changes in anti-Gal response during chronic rejection.Transplantation, 63 5
C. Larsen, E. Elwood, D. Alexander, S. Ritchie, R. Hendrix, C. Tucker-Burden, H. Cho, A. Aruffo, D. Hollenbaugh, P. Linsley, K. Winn, T. Pearson (1996)
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathwaysNature, 381
Y. Xu, T. Lorf, T. Sablinski, P. Gianello, M. Bailin, R. Monroy, T. Kozłowski, M. Awwad, D. Cooper, D. Sachs (1998)
Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column.Transplantation, 65 2
(1996)
In vivo immunoadsorption of antipig antibodies in baboons using a speci®c Gala1±3Gal column
(1995)
HEADLEE D, STETLER-STEVENSON M, et al
(1993)
Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation Transplantation
(1996)
Extracorporeal immunoadsorption of anti - pig antibody in pigs using a Gal oligosaccharide immunoaf ® nity columns
(1996)
immunoadsorption of anti- pig antibody in pigs using aGal oligosaccharide immunoaf®nity columns
Y. Ye, F. Neethling, M. Niekrasz, Eugen Koren, S. Richards, M. Martin, Stanley Kosanke, Rafael Oriol, D. Cooper (1994)
Evidence that intravenously administered alpha-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts.Transplantation, 58 3
(1996)
Long - term acceptance of skin and cardiac allografts after blocking CD 40 ligand
Fritz Bach, Simon Robson, Hans Winkler, Christiane Ferran, K. Stuhlmeier, Christopher Wrighton, Wayne Hancock (1995)
Barriers to xenotransplantationNature Medicine, 1
(1998)
SZABOLCS M, et al
U. Galili (1993)
Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans.Immunology today, 14 10
R. Oriol, F. Barthod, A. Bergemer, Y. Ye, E. Koren, D. Cooper (1994)
Monomorphic and polymorphic carbohydrate antigens on pig tissues: implications for organ xenotransplantation in the pig‐to‐human modelTransplant International, 7
U. Galili, R. Mandrell, Randa Hamadeh, S. Shohet, J. Griffiss (1988)
Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human floraInfection and Immunity, 56
(1997)
IDEC - C 2 B 8 results of a phase I multiple - dose trial in patients with relapsed non - Hodgkin ' s lymphoma
T. Kozłowski, F. Ierino, D. Lambrigts, A. Foley, D. Andrews, M. Awwad, R. Monroy, A. Cosimi, D. Cooper, D. Sachs (1998)
Depletion of anti‐Galα1–3Gal antibody in baboons by specific α‐Gal immunoaffinity columnsXenotransplantation, 5
D. Cooper, E. Koren, R. Oriol (1994)
Oligosaccharides and Discordant XenotransplantationImmunological Reviews, 141
(1987)
M, et al
O. Minanov, J. Artrip, M. Szabolcs, P. Kwiatkowski, U. Galili, S. Itescu, R. Michler (1998)
Triple immunosuppression reduces mononuclear cell infiltration and prolongs graft life in pig-to-newborn baboon cardiac xenotransplantation.The Journal of thoracic and cardiovascular surgery, 115 5
(1997)
FERRAN C, HECHENLEITNER P, et al
F. Bach, C. Ferran, P. Hechenleitner, W. Mark, N. Koyamada, Tsulasa Miyatake, H. Winkler, Anne Badrichant, D. Candinas, W. Hancock (1997)
Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environmentNature Medicine, 3
A. Shons, M. Bier, T. Jetzer, J. Najarian (1973)
Techniques of in vivo plasma modification for the treatment of hyperacute rejection.Surgery, 73 1
D. Cooper, P. Human, G. Lexer, A. Rose, J. Rees, M. Keraan, E. Toit (1988)
Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon.The Journal of heart transplantation, 7 3
Cooper Cooper, Human Human, Lexer Lexer (1988)
Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboonJ Heart Lung Transplant, 7
P. Macchiarini, R. Oriol, A. Azimzadeh, V. Montpreville, R. Rieben, N. Bovin, M. Mazmanian, P. Dartevelle (1998)
Evidence of human non-alpha-galactosyl antibodies involved in the hyperacute rejection of pig lungs and their removal by pig organ perfusion.The Journal of thoracic and cardiovascular surgery, 116 5
(1994)
KOREN E, ORIOL R
P. Mclaughlin, A. Grillo‐López, B. Link, R. Levy, M. Czuczman, M. Williams, M. Heyman, I. Bence-Bruckler, C. White, F. Cabanillas, V. Jain, A. Ho, J. Lister, K. Wey, D. Shen, B. Dallaire (1998)
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16 8
E. Koren, F. Neethling, S. Richards, M. Koscec, Y. Ye, N. Zuhdi, D. Cooper (1993)
Binding and specificity of major immunoglobulin classes of preformed human anti-pig heart antibodiesTransplant International, 6
D. Joziasse, J. Shaper, E. Jabs, N. Shaper (1991)
Characterization of an alpha 1----3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene.The Journal of biological chemistry, 266 11
A. Moberg, A. Shons, H. Gewurz, M. Mozes, J. Najarian (1971)
Prolongation of renal xenografts by the simultaneous sequestration of preformed antibody, inhibition of complement, coagulation and antibody synthesis.Transplantation proceedings, 3 1
(1979)
GARCIA-RINALDI R, MCCALMON R, et al
D. Goodman, M. Millan, C. Ferran, F. Bach (1997)
Mechanisms of Delayed Xenograft Rejection
(1997)
TUSCANO J, SATO S, et al
A. Palmer, K. Welsh, P. Gjorstrup, D. Taube, M. Bewick, M. Thick (1989)
REMOVAL OF ANTI-HLA ANTIBODIES BY EXTRACORPOREAL IMMUNOADSORPTION TO ENABLE RENAL TRANSPLANTATIONThe Lancet, 333
U. Galili, S. Shohet, E. Kobrin, C. Stults, B. Macher (1988)
Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.The Journal of biological chemistry, 263 33
L. Bühler, T. Friedman, J. Iacomini, D. Cooper (1999)
Xenotransplantation--state of the art--update 1999.Frontiers in bioscience : a journal and virtual library, 4
J. Leventhal, A. Dalmasso, J. Cromwell, J. Platt, C. Manivel, R. Bolman, A. Matas (1993)
Prolongation of cardiac xenograft survival by depletion of complement.Transplantation, 55 4
(1996)
JOZIASSE D, BOVIN N, et al
R. Perper, J. Najarian (1966)
EXPERIMENTAL RENAL HETEROTRANSPLANTATION: I. In Widely Divergent SpeciesTransplantation, 4
(1988)
LEXER G, et al
B. Coiffier, C. Haioun, N. Ketterer, A. Engert, H. Tilly, D. Ma, Peter Johnson, A. Lister, M. Feuring‐Buske, J. Radford, R. Capdeville, Volker Diehl, F. Reyes (1998)
Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study.Blood, 92 6
T. Kozłowski, R. Monroy, Y. Xu, R. Glaser, M. Awwad, D. Cooper, D. Sachs (1998)
Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction.Transplantation, 66 2
(1998)
Feasibility and pharmacokinitic study of a chimeric anti - CD 20 monoclonal antibody ( IDEC - C 2 B 8 ) in relapsed B cell lymphoma . The IDEC - C 2 B 8 study group
(1998)
TYAN D, CZER L, et al
D. Cooper (1998)
Xenoantigens and xenoantibodiesXenotransplantation, 5
M. Kujundžić, E. Koren, F. Neethling, Franko Mitotic, M. Koscec, Tatjana Kujundzic, Mic Martin, D. Cooper (1994)
Variability of anti‐αGal antibodies in human serum and their relation to serum cytotoxicity against pig cellsXenotransplantation, 1
Bouhours Bouhours, Pourcel Pourcel, Bouhours Bouhours (1996)
Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Galα1‐3Gal), blood group H determinant and N‐glycolylneuraminic acidGlycoconjugate J, 13
R. Noelle, M. Roy, D. Shepherd, I. Stamenkovic, J. Ledbetter, A. Aruffo (1992)
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.Proceedings of the National Academy of Sciences of the United States of America, 89 14
(1992)
STROCKBINE L, et al
(1999)
Long-term prognosis following zidovudine monotherapy in primary human immunode®ciency virus type 1 infection
G. Alexandre, J. Squifflet, M. Bruyere, D. Latinne, R. Reding, P. Gianello, M. Carlier, Y. Pirson (1987)
Present experiences in a series of 26 ABO-incompatible living donor renal allografts.Transplantation proceedings, 19 6
(1973)
BEIR M, JETZER J, et al
(1994)
Transplantation of fetal porcine pancreas to diabetic patients : Biochemical and histological evidence for graft survival
(1993)
of the natural anti-Gal antibody with agalactosyl epitopes: a major obstacle for xenotransplantation in humans
J. Magee, B. Collins, Robert, C. Harland, Bonnie, J. Lindman, R. Bollinger, M. Frank, J. Platt (1995)
Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.The Journal of clinical investigation, 96 5
(1989)
Plasmapheresis and splenectomy in experimental renal xenotransplantation
M. Schmoeckel, Farah Bhatti, A. Zaidi, E. Cozzi, P. Waterworth, M. Tolan, G. Pino-Chavez, Martin Goddard, R. Warner, G. Langford, John Dunning, J. Wallwork, David White (1998)
Orthotopic heart transplantation in a transgenic pig-to-primate model.Transplantation, 65 12
(1979)
Modi ® cation of hyperacute renal xenograft rejection after extracorporeal immunoadsorption of heterospeci - ® c antibody
T. Wekerle, M. Sayegh, Joshua Hill, Yong Zhao, A. Chandraker, K. Swenson, Guiling Zhao, M. Sykes (1998)
Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell ToleranceThe Journal of Experimental Medicine, 187
F. Neethling, D. Joziasse, Nicolai Bovin, D. Cooper, R. Oriol (1996)
The reducing end of αGal oligosaccharides contributes to their efficiency in blocking natural antibodies of human and baboon seraTransplant International, 9
T. Tedder, J. Tuscano, S. Sato, J. Kehrl (1997)
CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling.Annual review of immunology, 15
(1997)
FERRAN C, et al
Costanzo-Nordin Mr, Grusk Bb, Silver Ma, Sobotka Pa, G. Winters, J. O’Connell, R. Pifarré, J. Robinson (1988)
Reversal of recalcitrant cardiac allograft rejection with methotrexate.Circulation, 78 5 Pt 2
(1998)
and xenoantibodies
(1987)
incompatible renal transplantation: initial immunopathologic evaluation
M. Chopek, Simmons Rl, Jeffrey Platt (1987)
ABO-incompatible kidney transplantation: initial immunopathologic evaluation.Transplantation proceedings, 19 6
(1998)
Depletion of anti-aGal1±3Gal antibody in baboons by speci®c immunoaf®nity columns
Robert, D. Larsen, Carlos, A., Rivera-Marrerot, Linda, K., Ernst, Richard, D. CummingsQ, John, B. Lowe (2001)
Frameshift and Nonsense Mutations in a Human Genomic Sequence Homologous to a Murine UDP-Gal:&D-Gal( 1,4)-D-GlcNAc CY( 1,3)-Galactosyltransferase cDNA*
D. Cooper, Goodwin Ah, E. Koren, R. Oriol, Malcolm Aj, Ippolito Rm, F. Neethling, Y. Ye, E. Romano, N. Zuhdi (1993)
Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.Transplant immunology, 1 3
B. Murthy, A. Muerhoff, S. Desai, Jennifer Lund, Christopher Schmid, Andrew Levey, I. Mushahwar, BrianJ. Pereira (1997)
GB hepatitis agent in cadaver organ donors and their recipients.Transplantation, 63 3
Takaaki Kobayashi, S. Taniguchi, F. Neethling, Alan Rose, Wayne Hancock, Y. Ye, M. Niekrasz, Stanley Kosanke, L. Wright, David White, D. Cooper (1997)
Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy.Transplantation, 64 9
A. Kirk, D. Harlan, N. Armstrong, T. Davis, Yinchen Dong, G. Gray, X. Hong, David Thomas, J. Fechner, S. Knechtle (1997)
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.Proceedings of the National Academy of Sciences of the United States of America, 94 16
K. Reemtsma (1966)
Renal heterotransplantation.Advances in surgery, 2
E. Clave, G. Socié, J. Cosset, M. Chaillet, E. Tartour, T. Girinsky, E. Carosella, H. Fridman, E. Gluckman, C. Mathiot (1995)
Multicolor flow cytometry analysis of blood cell subsets in patients given total body irradiation before bone marrow transplantation.International journal of radiation oncology, biology, physics, 33 4
Egidio Romano, F. Neethling, K. Nilsson, S. Kosanke, A. Shimizu, S. Magnusson, L. Svensson, B. Samuelsson, D. Cooper (1999)
Intravenous synthetic αgal saccharides delay hyperacute rejection following pig‐to‐baboon heart transplantationXenotransplantation, 6
E. Sausville, D. Headlee, M. Stetler-Stevenson, E. Jaffe, D. Solomon, W. Figg, J. Herdt, W. Kopp, H. Rager, S. Steinberg (1995)
Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study.Blood, 85 12
L. Bühler, M. Awwad, M. Basker, S. Gojo, Anthony Watts, S. Treter, K. Nash, G. Oravec, Q. Chang, A. Thall, J. Down, Megan Sykes, D. Andrews, Robert Sackstein, M. White-Scharf, D. Sachs, D. Cooper (2000)
High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.Transplantation, 69 11
K. Lindsley, H. Deeg (1998)
Total body irradiation for marrow or stem-cell transplantation.Cancer investigation, 16 6
E. Elwood, C. Larsen, H. Cho, M. Corbascio, S. Ritchie, D. Alexander, C. Tucker-Burden, P. Linsley, A. Aruffo, D. Hollenbaugh, K. Winn, T. Pearson (1998)
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.Transplantation, 65 11
C. Groth, A. Tibell, J. Tollemar, J. Bolinder, J. Östman, E. Möller, F. Reinholt, O. Korsgren, C. Hellerström, A. Andersson (1994)
Transplantation of porcine fetal pancreas to diabetic patientsThe Lancet, 344
(1993)
KOREN E, et al
Eugen Koren, F. Milotič, F. Neethling, M. Koscec, David Fei, Takaaki Kobayashi, Shigeki Taniguchi, D. Cooper (1996)
Monoclonal antiidiotypic antibodies neutralize cytotoxic effects of anti-alphaGal antibodies.Transplantation, 62 6
F. Bach, J. Platt, D. Cooper (1991)
Accommodation — The Role of Natural Antibody and Complement in Discordant Xenograft Rejection
(1989)
GIANELLO P, LATINNE D, et al
(1994)
CARNER K, CHAMBERS KS, et al
Paul Simon, F. Neethling, Shigeki Taniguchi, P. Goode, David Zopf, Wayne Hancock, D. Cooper (1998)
Intravenous infusion of Galalpha1-3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts.Transplantation, 65 3
Mitchell, Reff, K. Carner, K. Chambers, P. Chinn, J. Leonard, Ron Raab, R. Newman, N. Hanna, D. Anderson (1994)
Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20.Blood, 83 2
K. McCurry, D. Kooyman, C. Alvarado, A. Cotterell, Michael Martin, J. Logan, J. Platt (1995)
Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injuryNature Medicine, 1
A. Azimzadeh, C. Meyer, H. Watier, J. Beller, M. Chenard-Neu, R. Kieny, K. Boudjema, D. Jaeck, J. Cinqualbre, P. Wolf (1998)
Removal of primate xenoreactive natural antibodies by extracorporeal perfusion of pig kidneys and livers.Transplant immunology, 6 1
A. Bolognesi, P. Tazzari, F. Olivieri, L. Polito, R. Lemoli, A. Terenzi, L. Pasqualucci, B. Falini, F. Stirpe (1998)
Evaluation of immunotoxins containing single‐chain ribosome‐inactivating proteins and an anti‐CD22 monoclonal antibody (OM124): in vitro and in vivo studiesBritish Journal of Haematology, 101
D. Maloney, A. Grillo‐López, D. Bodkin, C. White, T. Liles, I. Royston, C. Varns, J. Rosenberg, R. Levy (1997)
IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 15 10
(1998)
TANIGUCHI S, et al
C. Wordell (1991)
Use of Intravenous Immune Globulin Therapy: An OverviewAnnals of Pharmacotherapy, 25
Isabel McMorrow, C. Comrack, Pradeep Nazarey, David Sachs, Harout Dersimonian (1997)
Relationship between ABO blood group and levels of Gal alpha,3Galactose-reactive human immunoglobulin G.Transplantation, 64 3
(1992)
Molecular and biological characterization of a murine ligand for CD 40
D. Terman, R. García‐Rinaldi, R. McCalmon, C. Crumb, C. Mattioli, G. Cook, R. Poser (1979)
Modification of hyperacute renal xenograft rejection after extracorporeal immunoadsorption of heterospecific antibody.The International journal of artificial organs, 2 1
(1995)
WINKLER H, et al
D. Lambrigts, P. Calster, Yuanxin Xu, M. Awwad, F. Neethling, T. Kozłowski, A. Foley, A. Watts, Sanders Chae, J. Fishman, A. Thall, M. White-Scharf, D. Sachs, D. Cooper (1998)
Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti‐αGal antibody in the baboonXenotransplantation, 5
Tomasz Kozlowski, A. Shimizu, D. Lambrigts, Kazuhiko Yamada, Yasushi Fuchimoto, Roseann Glaser, Rod Monroy, Yuanxin Xu, M. Awwad, Robert Colvin, A. Cosimi, Simon Robson, Jay Fishman, Thomas Spitzer, D. Cooper, David Sachs (1999)
Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption.Transplantation, 67 1
R. Oriol, Y. Ye, E. Koren, D. Cooper (1993)
CARBOHYDRATE ANTIGENS OF PIG TISSUES REACTING WITH HUMAN NATURAL ANTIBODIES AS POTENTIAL TARGETS FOR HYPERACUTE VASCULAR REJECTION IN PIG‐TO‐MAN ORGAN XENOTRANSPLANTATION1Transplantation, 56
KORGSEN O, TIBELL A, et al
S. Lindbäck, J. Vizzard, D. Cooper, H. Gaines (1999)
Long-term prognosis following zidovudine monotherapy in primary human immunodeficiency virus type 1 infection.The Journal of infectious diseases, 179 6
R. Armitage, W. Fanslow, L. Strockbine, Timothy Sato, K. Clifford, B. Macduff, Dirk Anderson, S. Gimpel, T. Davis‐Smith, C. Maliszewski, E. Clark, Craig Smith, K. Grabstein, D. Cosman, M. Spriggs (1992)
Molecular and biological characterization of a murine ligand for CD40Nature, 357
G. Lexer, D. Cooper, Alan Rose, Wicomb Wn, J. Rees, M. Keraan, E. DuToit (1986)
Hyperacute rejection in a discordant (pig to baboon) cardiac xenograft model.The Journal of heart transplantation, 5 6
(1998)
Feasibility and pharmacokinitic study of a chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in relapsed B cell lymphoma
U. Galili (1997)
Anti-αgalactosyl (Anti-Gal) Antibody Damage Beyond Hyperacute Rejection
(1995)
Multicolor ̄ow cytometry analysis of blood cell subsets in patients given total body irradiation before bone marrow transplantation
(1984)
A unique natural human IgG antibody with anti-a-galactosyl speci®city
K. Tobinai, Yukio Kobayashi, Masaru Narabayashi, Michinori Ogura, Y. Kagami, Yasuo Morishima, T. Ohtsu, T. Igarashi, Y. Sasaki, Tomohiro Kinoshita, Takashi Murate (1998)
Feasibility and pharmacokinetic study of a chimeric anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab) in relapsed B-cell lymphoma. The IDEC-C2B8 Study Group.Annals of oncology : official journal of the European Society for Medical Oncology, 9 5
M. Sykes, D. Sachs (1997)
Xenogeneic Tolerance Through Hematopoietic Cell and Thymic Transplantation
U. Galili, P. Andrews (1995)
Suppression of α-galactosyl epitopes synthesis and production of the natural anti-Gal antibody: a major evolutionary event in ancestral Old World primatesJournal of Human Evolution, 29
A. Górski, P. Grieb, G. Korczak-Kowalska, P. Wierzbicki, B. Stepién-Sopniewska, T. Mrowiec (1993)
Cladribine (2-chloro-deoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro.Immunopharmacology, 26 3
Jeffrey Platt, Richard Fischel, A. Matas, Sally Reif, R. Bolman, Fritz Bach (1991)
Immunopathology of hyperacute xenograft rejection in a swine-to-primate model.Transplantation, 52 2
U. Galili, Rachmilewitz Ea, A. Peleg, I. Flechner (1984)
A unique natural human IgG antibody with anti-alpha-galactosyl specificityThe Journal of Experimental Medicine, 160
(1999)
in baboons undergoing a tolerance inducing regimen and antibody adsorption
R. Kaplon, Robert Michler, He Xu, Pawel Kwiatkowski, Niloo Edwards, Jeffrey Platt (1995)
Absence of hyperacute rejection in newborn pig-to-baboon cardiac xenografts.Transplantation, 59 1
W. Parker, K. Lundberg-Swanson, Z. Holzknecht, J. Lateef, Sara Washburn, S. Braedehoeft, J. Platt (1996)
Isohemagglutinins and xenoreactive antibodies: members of a distinct family of natural antibodies.Human immunology, 45 2
E. Cozzi, D. White (1995)
The generation of transgenic pigs as potential organ donors for humansNature Medicine, 1
Zhiya Yu, V. Lennon (1999)
Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases.The New England journal of medicine, 340 3
B. Collins, A. Cotterell, K. McCurry, C. Alvarado, J. Magee, W. Parker, J. Platt (1995)
Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection.Journal of immunology, 154 10
R Larsen, C Rivera-Marrero, L. Ernst, R Cummings, J. Lowe (1990)
Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA.The Journal of biological chemistry, 265 12
(1998)
Evaluation of immunotoxin containing single-chain ribosomeinactivating proteins and an anti-CD22 monoclonal antibody (OM124): in vitro and in vivo studies
D. Lambrigts, D. Sachs, D. Cooper (1998)
Discordant organ xenotransplantation in primates: world experience and current status.Transplantation, 66 5
(1988)
The interaction between the human anti-a-galactosyl IgG (anti-Gal) and bacteria of the human ̄ora
T. Sablinski, D. Latinne, P. Gianello, Michael Ballln, K. Bergen, R. Colvin, Alicia Foleys, H. Hong, T. Lorf, S. Meehan, R. Monroy, J. Powelson, Megan Sykess, Mayumi Tanaka, A. Cosimi, D. Sachs (1995)
Xenotransplantation of pig kidneys to nonhuman primates: I. Development of the modelXenotransplantation, 2
(1998)
Rituximab (antiCD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study
M. Sandrin, H. Vaughan, P. Dabkowski, I. McKenzie (1993)
Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.Proceedings of the National Academy of Sciences of the United States of America, 90 23
A. Rose, D. Cooper, P. Human, H. Reichenspurner, B. Reichart (1991)
Histopathology of hyperacute rejection of the heart: experimental and clinical observations in allografts and xenografts.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 10 2
E. Koren, M. Kujundžić, M. Koscec, F. Neethling, S. Richards, Y. Ye, N. Zuhdi, D. Cooper (1994)
Cytotoxic effects of human preformed anti-Gal IgG and complement on cultured pig cells.Transplantation proceedings, 26 3
(1998)
Life-supporting pig-to-primate renal xenotransplantation using genetically modi®ed donors Transplantation
The role of antibodies directed against Galα1–3Gal (α‐Gal) epitopes in porcine‐to‐primate xenotransplantation has been widely studied during the past few years. These antibodies (anti‐α‐Gal) have been associated with both hyperacute rejection and acute vascular rejection of vascularized organs. Depletion and (temporary or permanent) suppression of production of anti‐α‐Gal seem to be essential to the long‐term survival of these organs, even when the ultimate aim is accommodation or tolerance. Although more than 95% depletion of anti‐α‐Gal can be achieved by the use of immunoaffinity column technology, to date no regimen has been successful in preventing the return of anti‐α‐Gal from continuing production. In this review, we discuss current and novel methods for achieving depletion or inhibition (i.e. extracorporeal immunoadsorption, anti‐idiotypic antibodies, the intravenous infusion of immunoglobulin or oligosaccharides) and suppression of production (i.e. irradiation, pharmacologic agents, specific monoclonal antibodies, immunotoxins) of anti‐α‐Gal antibodies.
Xenotransplantation – Wiley
Published: Aug 1, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.