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The Primary Angioplasty in Myocardial Infarction Studies: An Overview

The Primary Angioplasty in Myocardial Infarction Studies: An Overview Introduction The purpose of the Primary Angioplasty in Myocardial Infarction (PAMI) study group is to conduct high quality scientific research with a specific focus on mechanical reperfusion strategies in acute myocardial infarction (MI). Our research ideas and hypotheses originate from joint collaboration of practicing physicians, and not the medical device or pharmaceutical industries. Specific objectives have included determination of the best methods of achieving high rates of normal coronary flow and low rates of reocclusion, determining the safest and most cost-effective reperfusion strategy, and how to effectively deliver acute MI treatments to patients regardless of their geographical location. PAMI-1 Observational trials had demonstrated that primary percutaneous transluminal coronary angioplasty (PTCA) was associated with early patency rates exceeding 90%, and low rates of intracranial bleeding, recurrent ischemia and death.' However, randomized trials of primary PTCA compared to thrombolytic therapy were necessary to determine which reperfusion strategy was superior. The PAMI-1 study involved 12 clinical centers that enrolled 395 patients within 12 hours of the onset of ML2 Patients were treated with intravenous heparin and aspirin, then randomly assigned to undergo PTCA as the primary Address for reprints: Cindy L. Grines, M.D., Division of Cardiology, William Beaumont Hospital, 3601 West http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interventional Cardiology Wiley

The Primary Angioplasty in Myocardial Infarction Studies: An Overview

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References (31)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0896-4327
eISSN
1540-8183
DOI
10.1111/j.1540-8183.1998.tb00103.x
Publisher site
See Article on Publisher Site

Abstract

Introduction The purpose of the Primary Angioplasty in Myocardial Infarction (PAMI) study group is to conduct high quality scientific research with a specific focus on mechanical reperfusion strategies in acute myocardial infarction (MI). Our research ideas and hypotheses originate from joint collaboration of practicing physicians, and not the medical device or pharmaceutical industries. Specific objectives have included determination of the best methods of achieving high rates of normal coronary flow and low rates of reocclusion, determining the safest and most cost-effective reperfusion strategy, and how to effectively deliver acute MI treatments to patients regardless of their geographical location. PAMI-1 Observational trials had demonstrated that primary percutaneous transluminal coronary angioplasty (PTCA) was associated with early patency rates exceeding 90%, and low rates of intracranial bleeding, recurrent ischemia and death.' However, randomized trials of primary PTCA compared to thrombolytic therapy were necessary to determine which reperfusion strategy was superior. The PAMI-1 study involved 12 clinical centers that enrolled 395 patients within 12 hours of the onset of ML2 Patients were treated with intravenous heparin and aspirin, then randomly assigned to undergo PTCA as the primary Address for reprints: Cindy L. Grines, M.D., Division of Cardiology, William Beaumont Hospital, 3601 West

Journal

Journal of Interventional CardiologyWiley

Published: Apr 1, 1998

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