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The phase problem for two‐dimensional crystals. II. Simulations

The phase problem for two‐dimensional crystals. II. Simulations Phasing of diffraction data from two‐dimensional crystals using only minimal molecular envelope information is investigated by simulation. Two‐dimensional crystals are an attractive target for studying membrane proteins using X‐ray free‐electron lasers, particularly for dynamic studies at room temperature. Simulations using an iterative projection algorithm show that phasing is feasible with fairly minimal molecular envelope information, supporting recent uniqueness results for this problem [Arnal & Millane (2017). Acta Cryst. A73, 438–448]. The effects of noise and likely requirements for structure determination using X‐ray free‐electron laser sources are investigated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Crystallographica Section A Foundations of Crystallography Wiley

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References (38)

Publisher
Wiley
Copyright
Copyright © 2018 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0108-7673
eISSN
1600-5724
DOI
10.1107/S2053273318008707
pmid
30182940
Publisher site
See Article on Publisher Site

Abstract

Phasing of diffraction data from two‐dimensional crystals using only minimal molecular envelope information is investigated by simulation. Two‐dimensional crystals are an attractive target for studying membrane proteins using X‐ray free‐electron lasers, particularly for dynamic studies at room temperature. Simulations using an iterative projection algorithm show that phasing is feasible with fairly minimal molecular envelope information, supporting recent uniqueness results for this problem [Arnal & Millane (2017). Acta Cryst. A73, 438–448]. The effects of noise and likely requirements for structure determination using X‐ray free‐electron laser sources are investigated.

Journal

Acta Crystallographica Section A Foundations of CrystallographyWiley

Published: Sep 1, 2018

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