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P. Ng, S. Henikoff (2003)
SIFT: predicting amino acid changes that affect protein functionNucleic acids research, 31 13
(2006)
BMC Bioinformatics BioMed Central Database
M. Gatz, C. Reynolds, L. Fratiglioni, B. Johansson, J. Mortimer, S. Berg, A. Fiske, N. Pedersen (2006)
Role of genes and environments for explaining Alzheimer disease.Archives of general psychiatry, 63 2
G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E. Stadlan (1984)
Clinical diagnosis of Alzheimer's diseaseNeurology, 34
L. Bertram, B. Schjeide, B. Hooli, K. Mullin, M. Hiltunen, H. Soininen, M. Ingelsson, L. Lannfelt, D. Blacker, R. Tanzi (2008)
No Association between CALHM1 and Alzheimer's Disease RiskCell, 135
G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E. Stadlan (2011)
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseNeurology, 77
E. Friedman (2002)
Alcohol consumption and risk of dementiaThe Lancet, 360
U. Dreses-Werringloer, J. Lambert, V. Vingtdeux, Haitian Zhao, H. Vais, Adam Siebert, Ankit Jain, J. Koppel, A. Rovelet-Lecrux, D. Hannequin, F. Pasquier, D. Galimberti, E. Scarpini, D. Mann, C. Lendon, D. Campion, P. Amouyel, P. Davies, P. Davies, J. Foskett, F. Campagne, P. Marambaud, P. Marambaud (2008)
A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease RiskCell, 133
I. Jang (2002)
Direct thrombin inhibitors in acute coronary syndromesThe Lancet, 360
R. Minster, F. Demirci, S. DeKosky, M. Kamboh (2009)
No association between CALHM1 variation and risk of Alzheimer diseaseHuman Mutation, 30
R. Deane, A. Sagare, Katie Hamm, Margaret Parisi, Steven Lane, M. Finn, D. Holtzman, B. Zlokovic (2008)
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.The Journal of clinical investigation, 118 12
S. Sunyaev, V. Ramensky, I. Koch, Warren Lathe, A. Kondrashov, P. Bork (2001)
Prediction of deleterious human alleles.Human molecular genetics, 10 6
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn (1997)
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysisJAMA, 278
K. Sleegers, N. Brouwers, K. Bettens, S. Engelborghs, Helen Miegroet, P. Deyn, C. Broeckhoven (2009)
No association between CALHM1 and risk for Alzheimer dementia in a Belgian populationHuman Mutation, 30
Carles Ferrer-Costa, J. Gelpí, Leire Zamakola, Ivan Parraga, X. Cruz, M. Orozco (2005)
PMUT: a web-based tool for the annotation of pathological mutations on proteinsBioinformatics, 21 14
Yue (2006)
SNPs3D: Candidate gene and SNP selection for association studiesBMC Bioinformatics, 7
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn (1997)
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.JAMA, 278 16
L. Bertram, M. McQueen, K. Mullin, D. Blacker, R. Tanzi (2007)
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene databaseNature Genetics, 39
S. Waring, R. Rosenberg (2008)
Genome-wide association studies in Alzheimer disease.Archives of neurology, 65 3
A common P86L variant in CALHM1 was recently identified to increase susceptibility to Alzheimer disease (AD) in individuals of European‐descent. To determine whether or not this association is also valid in a different ethnic population, we directly sequenced three nearby SNPs including P86L in more than 2,500 Japanese AD case–control samples. We found no association between CALHM1 P86L polymorphism and AD risk in Japanese individuals. We also found a small number of non‐synonymous minor variants in both control and case populations, some of which are predicted to affect protein function, but are unlikely to increase this risk of AD in this population. We also determined that the P86L allele frequency is lower in non‐Caucasian populations than in Caucasians. Our findings suggest that the CALHM1 P86L common variant may not influence AD risk in Japanese. © 2009 Wiley‐Liss, Inc.
American Journal of Medical Genetics part B – Wiley
Published: Mar 1, 2010
Keywords: Alzheimer disease; susceptibility; genetic risk; Asian; association study
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