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The measurement of fitness and mutation rate in human populations

The measurement of fitness and mutation rate in human populations The measurement of fitness and mutation rate in human populations BY BRIAN CHARLESWORTH AND DEBORAH CHARLESWORTH Department of Genetics, University of Liverpool, Liverpool, L69 3BX Human geneticists often wish to estimab the relative fitnesses of two or more genotypes, especially in connexion with the ‘indirect method’ of measuring the rate of mutation of a gene controlling a deleterious trait. Various methods for measuring relative genotypic fitnesses have been proposed by a number of authors (e.g. Reed & Neel, 1955; Krooth, 1955; Reed, 1959, Crow, 1962). The differences between these methods are not merely differences in approach to the statistical problems of estimation of the same parameter ‘fitness’; different parameters are being estimated, and the relations between them are by no means clear. This confusion arises from the fact that the standard models of population genetics are precisely defined only for populations where generations are distinct. In such populations, the fitness wi a genotype i is defined as its of expected number of offspring (parents and offspring being counted at the same stage in the lifecycle). The fitness of genotype i relative to that of a standard genotype j is measured as wi/wj. Relative genotypic fitnesses can be substituted http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

The measurement of fitness and mutation rate in human populations

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References (21)

Publisher
Wiley
Copyright
Copyright © 1973 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1973.tb01825.x
Publisher site
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Abstract

The measurement of fitness and mutation rate in human populations BY BRIAN CHARLESWORTH AND DEBORAH CHARLESWORTH Department of Genetics, University of Liverpool, Liverpool, L69 3BX Human geneticists often wish to estimab the relative fitnesses of two or more genotypes, especially in connexion with the ‘indirect method’ of measuring the rate of mutation of a gene controlling a deleterious trait. Various methods for measuring relative genotypic fitnesses have been proposed by a number of authors (e.g. Reed & Neel, 1955; Krooth, 1955; Reed, 1959, Crow, 1962). The differences between these methods are not merely differences in approach to the statistical problems of estimation of the same parameter ‘fitness’; different parameters are being estimated, and the relations between them are by no means clear. This confusion arises from the fact that the standard models of population genetics are precisely defined only for populations where generations are distinct. In such populations, the fitness wi a genotype i is defined as its of expected number of offspring (parents and offspring being counted at the same stage in the lifecycle). The fitness of genotype i relative to that of a standard genotype j is measured as wi/wj. Relative genotypic fitnesses can be substituted

Journal

Annals of Human Genetics – Wiley

Published: Oct 1, 1973

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