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The locus ordering problem

The locus ordering problem Summary Studies of phenotypes defined by codominant alleles at two or more loci in three‐generation families allow haplotypes to be deduced. These data are easily summarized by the Mendelian convention of upper and lower case, with case defining phase rather than nature. In two‐generation families haplotypes may be inferred with high precision for closely linked loci even if an allele at one locus is recessive. Coding procedures are discussed and a simple solution to inferring the most likely order of three or more loci, and defining its likelihood compared with other orders, is presented. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

The locus ordering problem

EDWARDS, J. H.
Annals of Human Genetics , Volume 51 (3) – Jul 1, 1987
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References (14)

Publisher
Wiley
Copyright
Copyright © 1987 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1987.tb00877.x
Publisher site
See Article on Publisher Site

Abstract

Summary Studies of phenotypes defined by codominant alleles at two or more loci in three‐generation families allow haplotypes to be deduced. These data are easily summarized by the Mendelian convention of upper and lower case, with case defining phase rather than nature. In two‐generation families haplotypes may be inferred with high precision for closely linked loci even if an allele at one locus is recessive. Coding procedures are discussed and a simple solution to inferring the most likely order of three or more loci, and defining its likelihood compared with other orders, is presented.

Journal

Annals of Human Genetics – Wiley

Published: Jul 1, 1987

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