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The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37

The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37 Summary A human placental alkaline phosphatase (PLAP) eDNA was isolated from a Λgt10 library of the cell line HEp‐2. Southern blots probed with a fragment of the eDNA clone showed that the human genome may contain more than one PLAP‐related sequence. The PLAP probe showed person‐to‐person variation in banding pattern with a number of enzymes. Using a panel of human/rodent somatic cell hybrids the PLAP sequences were mapped to chromosome 2. In situ hybridization confirmed this assignment and localized the gene(s) to chromosome 2 band q37. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37

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References (29)

Publisher
Wiley
Copyright
Copyright © 1987 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1987.tb01056.x
Publisher site
See Article on Publisher Site

Abstract

Summary A human placental alkaline phosphatase (PLAP) eDNA was isolated from a Λgt10 library of the cell line HEp‐2. Southern blots probed with a fragment of the eDNA clone showed that the human genome may contain more than one PLAP‐related sequence. The PLAP probe showed person‐to‐person variation in banding pattern with a number of enzymes. Using a panel of human/rodent somatic cell hybrids the PLAP sequences were mapped to chromosome 2. In situ hybridization confirmed this assignment and localized the gene(s) to chromosome 2 band q37.

Journal

Annals of Human GeneticsWiley

Published: May 1, 1987

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