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THE GENETICAL SOCIETY

THE GENETICAL SOCIETY ABSTRACTSOF PAPERS ATTEMPTS TO TEST THE INACTIVE-X. THEORY O F DOSAGE COMPENSATION I N MAMMALS M. F. LYO.N, M.R.C. Radiobiological Itesearch Unit, Harwell, Berks. This theory postulates that in the somatic cells of female mammals one of the two X-chromosomes is genetically inactivated and, since either one may be inactive in different cells of the same animal, that this gives rise to the mosaic phenotype of female mammak hoterozygous for sex-linked genes. It follows that if a fcmalc carries two non-allelic sex-linked mutant gencs affecting the same character, one on each X-ohromosomc, then one or other mutant should act in all her cells, and she should have no normal patches. Attempts are being made to confirm this for three pairs of mouse mutants affecting coat colour and coat structure. Female mice homozygous for pp and carrying Cattanach’s translocation (including the allele + P ) on one X-chromosome are variegated wild-type/pink-eye. Similar mice with the gene M o d p on the other X-chromosome show no pp patches and are indistinguishable from ordinary M o d P + , i.c. either the gene M o d P or the tramlocation, and hence the $. p allele, is active in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

THE GENETICAL SOCIETY

Annals of Human Genetics , Volume 25 (4) – May 1, 1962
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Publisher
Wiley
Copyright
Copyright © 1962 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1962.tb01776.x
Publisher site
See Article on Publisher Site

Abstract

ABSTRACTSOF PAPERS ATTEMPTS TO TEST THE INACTIVE-X. THEORY O F DOSAGE COMPENSATION I N MAMMALS M. F. LYO.N, M.R.C. Radiobiological Itesearch Unit, Harwell, Berks. This theory postulates that in the somatic cells of female mammals one of the two X-chromosomes is genetically inactivated and, since either one may be inactive in different cells of the same animal, that this gives rise to the mosaic phenotype of female mammak hoterozygous for sex-linked genes. It follows that if a fcmalc carries two non-allelic sex-linked mutant gencs affecting the same character, one on each X-ohromosomc, then one or other mutant should act in all her cells, and she should have no normal patches. Attempts are being made to confirm this for three pairs of mouse mutants affecting coat colour and coat structure. Female mice homozygous for pp and carrying Cattanach’s translocation (including the allele + P ) on one X-chromosome are variegated wild-type/pink-eye. Similar mice with the gene M o d p on the other X-chromosome show no pp patches and are indistinguishable from ordinary M o d P + , i.c. either the gene M o d P or the tramlocation, and hence the $. p allele, is active in

Journal

Annals of Human Genetics – Wiley

Published: May 1, 1962

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