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Tina Han, G. Vries (1999)
Neurogenesis of galanin cells in the bed nucleus of the stria terminalis and centromedial amygdala in rats: a model for sexual differentiation of neuronal phenotype.Journal of neurobiology, 38 4
S. Linsambarth, R. Moraga-Amaro, Daisy Quintana-Donoso, Sebastián Rojas, J. Stehberg (2017)
The Amygdala and Anxiety
H. Pape, D. Paré (2010)
Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear.Physiological reviews, 90 2
M. Bupesh, I. Legaz, A. Abellán, L. Medina (2011)
Multiple telencephalic and extratelencephalic embryonic domains contribute neurons to the medial extended amygdalaJournal of Comparative Neurology, 519
S. Herculano‐Houzel, P. Manger, J. Kaas (2014)
Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size.Frontiers in neuroanatomy, 8
P. Sah, E. Faber, M. Armentia, J. Power (2003)
The amygdaloid complex: anatomy and physiology.Physiological reviews, 83 3
L. Medina, I. Legaz, Gertrudis González, F. Castro, J. Rubenstein, L. Puelles (2004)
Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complexJournal of Comparative Neurology, 474
M. Równiak (2013)
The amygdala in the guinea pig is sexually dimorphic—A morphometric studyBrain Research, 1524
B. Finlay, R. Darlington, Nicholas Nicastro (2001)
Developmental structure in brain evolutionBehavioral and Brain Sciences, 24
A. Breathnach, F. Goldby (1954)
The amygdaloid nuclei, hippocampus and other parts of the rhinencephalon in the porpoise (Phocaena phocaena).Journal of anatomy, 88 3
Joseph LeDoux (2000)
Emotion Circuits in the BrainAnnual Review of Neuroscience, 23
F. Rohlf (1999)
Shape Statistics: Procrustes Superimpositions and Tangent SpacesJournal of Classification, 16
Ryan Remedios, Dhananjay Huilgol, Bhaskar Saha, P. Hari, L. Bhatnagar, Tom Kowalczyk, R. Hevner, Y. Suda, S. Aizawa, T. Ohshima, Anastassia Stoykova, S. Tole (2007)
A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortexNature Neuroscience, 10
Nicolas Gutierrez-Castellanos, A. Martínez-Marcos, F. Martínez-García, E. Lanuza (2010)
Chemosensory function of the amygdala.Vitamins and hormones, 83
J. Fiala, K. Harris (2001)
Synthesis of Research: Extending Unbiased Stereology of Brain Ultrastructure to Three-dimensional VolumesJournal of the American Medical Informatics Association : JAMIA, 8 1
B. Ferry (2017)
The Amygdala - Where Emotions Shape Perception, Learning and Memories
M. Równiak, A. Robak, S. Szteyn, K. Bogus-Nowakowska, B. Wasilewska, J. Najdzion (2007)
The morphometric study of the amygdala in the rabbit.Folia morphologica, 66 1
G. Baron, H. Stephan, H. Frahm (1987)
Comparison of brain structure volumes in Insectivora and primates. VI. Paleocortical components.Journal fur Hirnforschung, 28 4
A. McDonald (2020)
Functional neuroanatomy of the basolateral amygdala: Neurons, neurotransmitters, and circuits.Handbook of behavioral neuroscience, 26
F. Rohlf, D. Slice (1990)
Extensions of the Procrustes Method for the Optimal Superimposition of LandmarksSystematic Biology, 39
H. Schröder, N. Moser, S. Huggenberger (2020)
Neuroanatomy of the Mouse: An IntroductionNeuroanatomy of the Mouse
G. Kevetter, S. Winans (1981)
Connections of the corticomedial amygdala in the golden hamster. II. Efferents of the “olfactory amygdala”Journal of Comparative Neurology, 197
Richardson Js (1973)
The amygdala: historical and functional analysis.Acta neurobiologiae experimentalis, 33 3
S. Montgomery, N. Mundy, R. Barton (2016)
Brain evolution and development: adaptation, allometry and constraintProceedings of the Royal Society B: Biological Sciences, 283
P. Janak, K. Tye (2015)
From circuits to behaviour in the amygdalaNature, 517
L. Medina, I. Legaz, G. González, F. De Castro, J.L. Rubenstein, L. Puelles (2004)
Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex: pallial divisions of claustrum and amygdala, 474
E. Prager, H. Bergstrom, Gary Wynn, M. Braga (2016)
The basolateral amygdala γ‐aminobutyric acidergic system in health and diseaseJournal of Neuroscience Research, 94
M. West, H. Gundersen (1990)
Unbiased stereological estimation of the number of neurons in the human hippocampusJournal of Comparative Neurology, 296
Heinz Stephan, Frahm Hd, Georg Baron (1987)
Comparison of brain structure volumes in Insectivora and primates. VII. Amygdaloid components.Journal fur Hirnforschung, 28 5
Mohan Pabba (2013)
Evolutionary development of the amygdaloid complexFrontiers in Neuroanatomy, 7
G. Kevetter, S. Winans (1981)
Connections of the corticomedial amygdala in the golden hamster. I. Efferents of the “vomeronasal amygdala”Journal of Comparative Neurology, 197
L. Puelles, E. Kuwana, E. Puelles, A. Bulfone, K. Shimamura, Jerry Keleher, S. Smiga, J. Rubenstein (2000)
Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx‐2, Emx‐1, Nkx‐2.1, Pax‐6, and Tbr‐1Journal of Comparative Neurology, 424
P. Maras, A. Petrulis (2008)
The posteromedial cortical amygdala regulates copulatory behavior, but not sexual odor preference, in the male Syrian hamster (Mesocricetus auratus)Neuroscience, 156
J. Muller, F. Mascagni, A. McDonald (2005)
Coupled Networks of Parvalbumin-Immunoreactive Interneurons in the Rat Basolateral AmygdalaThe Journal of Neuroscience, 25
E.M. Prager, H.C. Bergstrom, G.H. Wynn, M.F.M. Braga (2016)
The basolateral amygdala gabaergic system in health and disease, 94
M. Davis, C. Shi (2000)
The amygdalaCurrent Biology, 10
Swanson L.W. (1998)
10.1016/S0166-2236(98)01265-XTrends in Neurosciences, 21
R. Barton, P. Harvey (2000)
Mosaic evolution of brain structure in mammalsNature, 405
Frahm Hd, H. Stephan, M. Stephan (1982)
Comparison of brain structure volumes in Insectivora and Primates. I. Neocortex.Journal fur Hirnforschung, 23 4
G. Baron, H. Frahm, K. Bhatnagar, H. Stephan (1983)
Comparison of brain structure volumes in Insectivora and Primates. III. Main olfactory bulb (MOB).Journal fur Hirnforschung, 24 5
Weizhe Hong, Dong-Wook Kim, D. Anderson (2014)
Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal SubsetsCell, 158
M. Równiak, S. Szteyn, A. Robak (2003)
A comparative study of the mammalian amygdala: a Golgi study of the basolateral amygdala.Folia morphologica, 62 4
J.C. Fiala, K.M. Harris (2001)
Extending unbiased stereology of brain ultrastructure to three‐dimensional volumes, 8
M. Równiak, K. Bogus-Nowakowska (2020)
The amygdala of the common shrew, guinea pig, rabbit, fox and pig: five flavours of the mammalian amygdala as a consequence of clade‐specific mosaic‐like evolutionJournal of Anatomy, 236
L. Puelles (2017)
Comments on the Updated Tetrapartite Pallium Model in the Mouse and Chick, Featuring a Homologous Claustro-Insular ComplexBrain, Behavior and Evolution, 90
C. Carlo, L. Stefanacci, L. Stefanacci, K. Semendeferi, C. Stevens, Charles Stevens (2009)
Comparative analyses of the neuron numbers and volumes of the amygdaloid complex in old and new world primatesJournal of Comparative Neurology, 518
M. Równiak, A. Robak, S. Szteyn, K. Bogus-Nowakowska, B. Wasilewska, J. Najdzion (2005)
A morphometric study of the amygdala in the guinea pig.Folia morphologica, 64 3
S. Newman (1999)
The Medial Extended Amygdala in Male Reproductive Behavior A Node in the Mammalian Social Behavior NetworkAnnals of the New York Academy of Sciences, 877
J. Boissonnat (1988)
Shape reconstruction from planar cross sectionsComput. Vis. Graph. Image Process., 44
Nicole Barger, L. Stefanacci, C. Schumann, C. Sherwood, J. Annese, J. Allman, J. Buckwalter, P. Hof, K. Semendeferi (2012)
Neuronal populations in the basolateral nuclei of the amygdala are differentially increased in humans compared with apes: A stereological studyJournal of Comparative Neurology, 520
J. Fiala (2005)
Reconstruct: a free editor for serial section microscopyJournal of Microscopy, 218
LeDoux J. (2007)
10.1016/j.cub.2007.08.005Current Biology, 17
A.J. McDonald (2020)
Handbook of behavioral neuroscience
F. Bookstein (1986)
Size and Shape Spaces for Landmark Data in Two DimensionsStatistical Science, 1
F. Martínez-García, A. Martínez-Marcos, E. Lanuza (2002)
The pallial amygdala of amniote vertebrates: evolution of the concept, evolution of the structureBrain Research Bulletin, 57
A. Pitkänen, E. Jolkkonen, S. Kemppainen (2000)
Anatomic heterogeneity of the rat amygdaloid complex.Folia morphologica, 59 1
Joseph LeDoux (2003)
The Emotional Brain, Fear, and the AmygdalaCellular and Molecular Neurobiology, 23
N. Moreno, Agustín González (2007)
Evolution of the amygdaloid complex in vertebrates, with special reference to the anamnio‐amniotic transitionJournal of Anatomy, 211
L.W. Swanson, G.D. Petrovich (1998)
What is the amygdala?, 21
E. Crosby, T. Humphrey (1944)
Studies of the vertebrate telencephalon. III. The amygdaloid complex in the shrew (Blarina brevicauda)Journal of Comparative Neurology, 81
M. Równiak, S. Szteyn, A. Robak (2004)
A morphometric study of the amygdala in the common shrew.Folia morphologica, 63 4
J. Krettek, J. Price (1978)
A description of the amygdaloid complex in the rat and cat with observations on intra‐amygdaloid axonal connectionsJournal of Comparative Neurology, 178
E. Garcia-Calero, M. Martı́nez-de-la-Torre, L. Puelles (2020)
A radial histogenetic model of the mouse pallial amygdalaBrain Structure & Function, 225
Loïc Chareyron, P. Lavenex, D. Amaral, P. Lavenex (2011)
Stereological analysis of the rat and monkey amygdalaJournal of Comparative Neurology, 519
The amygdala primarily evolved as a danger detector that regulates emotional behaviours and learning. However, it is also engaged in stress responses as well as olfactory/pheromonal and reproductive functions. All of these functions are processed by a set of nuclei which are derived from different telencephalic sources (pallial and subpallial) and have a unique cellular structure and specific connections. It is unclear how these individual anatomical and functional units evolved to fit the amygdala to the specific needs of various mammals. Thus, this study provides quantitative data regarding volumes, neuron density and neuron numbers in the main amygdala nuclei of the common shrew, guinea pig, rabbit, fox and pig – species from across the mammalian phylogeny which differ in brain complexity and ecology. The results show that the volume of the amygdala and its individual nuclei scale with negative allometry relative to brain mass (an allometric coefficient below one). However, in relation to the whole amygdala volume, volumes and volumetric percentages of the lateral (LA) and basomedial (BM) nuclei scale with positive allometry, for the medial (ME) and lateral olfactory tract (NLOT) nuclei these parameters scale with negative allometry while the values of these parameters for the basolateral (BL), central (CE) and cortical (CO) nuclei scale with isometry. Moreover, density of neurons scales with strong negative allometry relative to both brain mass and amygdala volume with values of allometric coefficient below zero across studied species. This value for BL is significantly lower than that for the whole amygdala, for ME it is significantly higher while values for NLOT, CE, CO, LA and BM are quite similar to the value for whole amygdala. Finally, neuron numbers in the whole amygdala and its individual nuclei scale with negative allometry in relation to brain mass. However, in relation to the number of neurons in the whole amygdala, neuron numbers and percentages of neurons for LA and BM scale with positive allometry, for BL and NLOT they scale with negative allometry while the values of these parameters for CE, CO and ME scale with isometry. In conclusion, all of these results indicate that each of the nuclei studied displays a different and unique pattern of evolution in relation to brain mass or the whole amygdala volume. These patterns do not match with the various classical concepts of amygdala parcellation; however, in some way, they reflect diversity revealed by the expression of homeobox genes in various embryological studies.
Journal of Anatomy – Wiley
Published: Mar 1, 2022
Keywords: amygdala; comparative neuroanatomy; mammalian evolution; neuron density; neuron number; stereology; volume
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