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THE ESTIMATION OF GENE FREQUENCIES IN A RANDOM‐MATING POPULATION

THE ESTIMATION OF GENE FREQUENCIES IN A RANDOM‐MATING POPULATION BY R. CEPPELLINI, lstituto Sieroterapico Milanese, Milano, Italy M. SINISCALCO, Istituto d i Genetica, Universitri, Napoli, Italy AND C. A. B. SMITH, Galton Laboratory, University College, London 1. The estimation of gene frequencies in a population is an important problem in human genetics and anthropology, especially where blood groups are concerned. Much work has already been done on this problem, notably by W. L. Stevens (1938), R. A. Fisher (1940, 1946), C. W. Cotterman (1947), D. J. Finney (1948a, b), W. C. Boyd (1954a, b ) , and others. Here we give a general procedure applicable (under very general conditions) both to samples of unrelated individuals and to families. This method is applied to data on blood groups collected from villages near the mouth of the River Po, in northern Italy, in the course of an investigation on microcythaemia (Bianco, Ceppellini, Silvestroni & Siniscalco, 1954). Experience shows that this new method of computation is reasonably rapid, except in the case of a rare, or fairly rare, recessive gene, or when such a gene is present in a series of alleles. It may also become laborious when there are complicated families and a system of several alleles; in this http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

THE ESTIMATION OF GENE FREQUENCIES IN A RANDOM‐MATING POPULATION

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References (14)

Publisher
Wiley
Copyright
Copyright © 1955 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1955.tb01360.x
Publisher site
See Article on Publisher Site

Abstract

BY R. CEPPELLINI, lstituto Sieroterapico Milanese, Milano, Italy M. SINISCALCO, Istituto d i Genetica, Universitri, Napoli, Italy AND C. A. B. SMITH, Galton Laboratory, University College, London 1. The estimation of gene frequencies in a population is an important problem in human genetics and anthropology, especially where blood groups are concerned. Much work has already been done on this problem, notably by W. L. Stevens (1938), R. A. Fisher (1940, 1946), C. W. Cotterman (1947), D. J. Finney (1948a, b), W. C. Boyd (1954a, b ) , and others. Here we give a general procedure applicable (under very general conditions) both to samples of unrelated individuals and to families. This method is applied to data on blood groups collected from villages near the mouth of the River Po, in northern Italy, in the course of an investigation on microcythaemia (Bianco, Ceppellini, Silvestroni & Siniscalco, 1954). Experience shows that this new method of computation is reasonably rapid, except in the case of a rare, or fairly rare, recessive gene, or when such a gene is present in a series of alleles. It may also become laborious when there are complicated families and a system of several alleles; in this

Journal

Annals of Human GeneticsWiley

Published: Nov 1, 1955

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