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The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee

The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee AbbreviationsFIXfactor IXFVIIIfactor VIIIHEAD‐US‐CHemophilia Early Detection Ultrasound in ChinaHJHSHemophilia Joint Health ScoreHemophilia A and B are rare, inherited bleeding disorders characterized by the deficiency of coagulation factor VIII (FVIII) or factor IX (FIX).1 The severity of hemophilia is classified according to the patient's baseline level of FVIII or FIX, where >5 IU/dL is considered mild, 1–5 IU/dL is considered moderate, and <1 U/dL is considered severe hemophilia.1 A meta‐analysis of national registries estimated the worldwide prevalence of hemophilia A and B in men to be 17.1 and 3.8 cases per 100,000, respectively.2 The main clinical feature of hemophilia is spontaneous bleeding in soft tissues, joints, muscles, and other body parts, as well as persistent bleeding after minor bumps and injuries.3 Recurrent bleeding in the joint cavity may cause permanent joint damage, which markedly contributes to decreased quality of life and even disability in patients with hemophilia.4 In case of repeated or extensive joint bleeding, a large amount of hemosiderin is deposited into the synovial membrane of the joint cavity. The synovial membrane can absorb decomposition products; however, excessive hemosiderin amounts cause changes in the metabolic properties of the synovial membrane, which can lead to synovitis. Synovial membranes can produce large amounts of pro‐inflammatory cytokines http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Ultrasound in Medicine Wiley

The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee

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References (29)

Publisher
Wiley
Copyright
© 2023 American Institute of Ultrasound in Medicine
ISSN
0278-4297
eISSN
1550-9613
DOI
10.1002/jum.16072
Publisher site
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Abstract

AbbreviationsFIXfactor IXFVIIIfactor VIIIHEAD‐US‐CHemophilia Early Detection Ultrasound in ChinaHJHSHemophilia Joint Health ScoreHemophilia A and B are rare, inherited bleeding disorders characterized by the deficiency of coagulation factor VIII (FVIII) or factor IX (FIX).1 The severity of hemophilia is classified according to the patient's baseline level of FVIII or FIX, where >5 IU/dL is considered mild, 1–5 IU/dL is considered moderate, and <1 U/dL is considered severe hemophilia.1 A meta‐analysis of national registries estimated the worldwide prevalence of hemophilia A and B in men to be 17.1 and 3.8 cases per 100,000, respectively.2 The main clinical feature of hemophilia is spontaneous bleeding in soft tissues, joints, muscles, and other body parts, as well as persistent bleeding after minor bumps and injuries.3 Recurrent bleeding in the joint cavity may cause permanent joint damage, which markedly contributes to decreased quality of life and even disability in patients with hemophilia.4 In case of repeated or extensive joint bleeding, a large amount of hemosiderin is deposited into the synovial membrane of the joint cavity. The synovial membrane can absorb decomposition products; however, excessive hemosiderin amounts cause changes in the metabolic properties of the synovial membrane, which can lead to synovitis. Synovial membranes can produce large amounts of pro‐inflammatory cytokines

Journal

Journal of Ultrasound in Medicine – Wiley

Published: Apr 1, 2023

Keywords: hemophilia; hemophilic arthropathy; Hemophilia Joint Health Score; ultrasound

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