Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Bladt, D. Riethmacher, S. Isenmann, A. Aguzzi, C. Birchmeier (1995)
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budNature, 376
R. Tuchman, I. Rapin (2002)
Epilepsy in autismThe Lancet Neurology, 1
E. Courchesne, K. Pierce (2005)
Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnectionCurrent Opinion in Neurobiology, 15
K. Eagleson, M. Gravielle, L. McFadyen-Ketchum, S. Russek, D. Farb, P. Levitt (2010)
Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changesNeuroscience, 168
A. Orzechowski (2007)
Possible implications of redox-sensitive tumour cell transformation; lessons from cell culture studies.Polish journal of veterinary sciences, 10 2
Paul Berghuis, M. Dobszay, Kyle Sousa, G. Schulte, P. Mager, W. Härtig, T. Görcs, Y. Zilberter, P. Ernfors, T. Harkany (2004)
Brain‐derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast‐spiking GABAergic interneuronsEuropean Journal of Neuroscience, 20
S. Patz, J. Grabert, T. Gorba, M. Wirth, P. Wahle (2004)
Parvalbumin expression in visual cortical interneurons depends on neuronal activity and TrkB ligands during an Early period of postnatal development.Cerebral cortex, 14 3
Ivana Rosová, M. Dao, Benjamin Capoccia, D. Link, J. Nolta (2008)
Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem CellsSTEM CELLS, 26
A. Lavdas, M. Grigoriou, V. Pachnis, J. Parnavelas (1999)
The Medial Ganglionic Eminence Gives Rise to a Population of Early Neurons in the Developing Cerebral CortexThe Journal of Neuroscience, 19
A. Cellerino, L. Maffei, L. Domenici (1996)
The Distribution of Brain‐derived Neurotrophic Factor and its Receptor trkB in Parvlbumin‐containing Neurons of the Rat Visual CortexEuropean Journal of Neuroscience, 8
G. Bissonette, Mihyun Bae, T. Suresh, D. Jaffe, E. Powell (2010)
Astrocyte-Mediated Hepatocyte Growth Factor/Scatter Factor Supplementation Restores GABAergic Interneurons and Corrects Reversal Learning Deficits in MiceThe Journal of Neuroscience, 30
Ralph Rabkin, F. Fervenza, T. Tsao, Richard Sibley, Michael Friedlaender, Fay Hsu, Charles Lassman, Michael Hausmann, Philip Huie, Ralph Schwall (2001)
Hepatocyte growth factor receptor in acute tubular necrosis.Journal of the American Society of Nephrology : JASN, 12 3
M. Judson, K. Eagleson, Lily Wang, P. Levitt (2010)
Evidence of cell‐nonautonomous changes in dendrite and dendritic spine morphology in the met‐signaling–deficient mouse forebrainJournal of Comparative Neurology, 518
S. Yoshida, Sadao Shiosaka (1999)
Plasticity-related serine proteases in the brain (review).International journal of molecular medicine, 3 4
N. Minshew, Diane Williams (2007)
The new neurobiology of autism: cortex, connectivity, and neuronal organization.Archives of neurology, 64 7
E. Colombo, G. Menicucci, P. McGuire, A. Das (2007)
Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression.Investigative ophthalmology & visual science, 48 4
M. Hayashi, M. Sakata, T. Takeda, M. Tahara, Toshiya Yamamoto, Y. Okamoto, R. Minekawa, A. Isobe, M. Ohmichi, K. Tasaka, Y. Murata (2005)
Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension.Endocrinology, 146 11
Xiao (2001)
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathwaysProceedings of the National Academy of Sciences, USA, 98
B. Abrahams, D. Geschwind (2008)
Advances in autism genetics: on the threshold of a new neurobiologyNature Reviews Genetics, 9
C. Eckerich, S. Zapf, Regina Fillbrandt, S. Loges, M. Westphal, K. Lamszus (2007)
Hypoxia can induce c‐Met expression in glioma cells and enhance SF/HGF‐induced cell migrationInternational Journal of Cancer, 121
Jan Stenman, H. Toresson, K. Campbell (2003)
Identification of Two Distinct Progenitor Populations in the Lateral Ganglionic Eminence: Implications for Striatal and Olfactory Bulb NeurogenesisThe Journal of Neuroscience, 23
C-H Tang, Y. Wei (2008)
The urokinase receptor and integrins in cancer progressionCellular and Molecular Life Sciences, 65
M. Beilmann, G. Woude, H. Dienes, P. Schirmacher (2000)
Hepatocyte growth factor-stimulated invasiveness of monocytes.Blood, 95 12
J. Mann, S. McDermott, Haikun Bao, J. Hardin, A. Gregg (2010)
Pre-Eclampsia, Birth Weight, and Autism Spectrum DisordersJournal of Autism and Developmental Disorders, 40
P. Lalive, R. Paglinawan, G. Biollaz, E. Kappos, Dino Leone, U. Malipiero, J. Relvas, M. Moransard, T. Suter, A. Fontana (2005)
TGF‐β‐treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF‐c‐Met pathwayEuropean Journal of Immunology, 35
T. Nagayama, M. Nagayama, S. Kohara, H. Kamiguchi, M. Shibuya, Y. Katoh, J. Itoh, Y. Shinohara (2004)
Post-ischemic delayed expression of hepatocyte growth factor and c-Met in mouse brain following focal cerebral ischemiaBrain Research, 999
Kazuya Kitamura, A. Iwanami, M. Nakamura, J. Yamane, Kota Watanabe, Yoshinori Suzuki, Daisuke Miyazawa, S. Shibata, H. Funakoshi, S. Miyatake, R. Coffin, Toshikazu Nakamura, Y. Toyama, H. Okano (2007)
Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injuryJournal of Neuroscience Research, 85
P. Jackson, L. Boccuto, C. Skinner, J. Collins, G. Neri, F. Gurrieri, C. Schwartz (2009)
Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorderAutism Research, 2
Just (2007)
Functional and anatomical cortical underconnectivity in autism: Evidence from an FMRI study of an executive function task and corpus callosum morphometryCerebral Cortex, 17
Diana Wilkerson, Alessandra Volpe, R. Dean, J. Titus (2002)
PERINATAL COMPLICATIONS AS PREDICTORS OF INFANTILE AUTISMInternational Journal of Neuroscience, 112
D. Kinney, K. Munir, David Crowley, A. Miller (2008)
Prenatal stress and risk for autismNeuroscience & Biobehavioral Reviews, 32
K. Owen, D. Qiu, J. Alves, A. Schumacher, L. Kilpatrick, Jun Li, Jennifer Harris, V. Ellis (2010)
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.The Biochemical journal, 426 2
C. Frith (2004)
Is autism a disconnection disorder?The Lancet Neurology, 3
Y. Okura, H. Arimoto, N. Tanuma, Kunio Matsumoto, Toshikazu Nakamura, T. Yamashima, T. Miyazawa, Y. Matsumoto (1999)
Analysis of neurotrophic effects of hepatocyte growth factor in the adult hypoglossal nerve axotomy modelEuropean Journal of Neuroscience, 11
Teruya Nakamura, S. Mizuno, Kunio Matsumoto, Yoshiki Sawa, Hikaru Matsuda, Toshikazu Nakamura (2000)
Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF.The Journal of clinical investigation, 106 12
T. Gorba, P. Wahle (1999)
Expression of TrkB and TrkC but not BDNF mRNA in neurochemically identified interneurons in rat visual cortex in vivo and in organotypic culturesEuropean Journal of Neuroscience, 11
Mariëlle Handel, H. Swaab, L. Vries, M. Jongmans (2007)
Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a reviewEuropean Journal of Pediatrics, 166
T. Ide, Y. Kitajima, Atsushi Miyoshi, T. Ohtsuka, Mayumi Mitsuno, Kazuma Ohtaka, Y. Koga, K. Miyazaki (2006)
Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathwayInternational Journal of Cancer, 119
N. Meiri, T. Masos, Kobi Rosenblum, R. Miskin, Y. Dudai (1994)
Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning.Proceedings of the National Academy of Sciences of the United States of America, 91
C. Birchmeier, W. Birchmeier, E. Gherardi, G. Woude (2003)
Met, metastasis, motility and moreNature Reviews Molecular Cell Biology, 4
I. Sousa, T. Clark, C. Toma, Kazuhiro Kobayashi, Maja Choma, R. Holt, N. Sykes, J. Lamb, A. Bailey, A. Battaglia, E. Maestrini, A. Monaco (2009)
MET and autism susceptibility: family and case–control studiesEuropean Journal of Human Genetics, 17
N. Lokker, M. Mark, E. Luis, G. Bennett, K. Robbins, Joffre Bakerl, P. Godowski (1992)
Structure‐function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.The EMBO Journal, 11
Myrna Dent, Y. Sumi, R. Morris, P. Seeley (1993)
Urokinase‐type Plasminogen Activator Expression by Neurons and Oligodendrocytes During Process Outgrowth in Developing Rat BrainEuropean Journal of Neuroscience, 5
A. Kolevzon, R. Gross, A. Reichenberg (2007)
Prenatal and perinatal risk factors for autism: a review and integration of findings.Archives of pediatrics & adolescent medicine, 161 4
M. Bigio, S. Hosain, M. Altumbabic (1999)
Localization of urokinase-type plasminogen activator, its receptor, and inhibitors in mouse forebrain during postnatal developmentInternational Journal of Developmental Neuroscience, 17
M. Joannidis, K. Spokes, T. Nakamura, D. Faletto, L. Cantley (1994)
Regional expression of hepatocyte growth factor/c-met in experimental renal hypertrophy and hyperplasia.The American journal of physiology, 267 2 Pt 2
Paul El-Fishawy, M. State (2010)
The genetics of autism: key issues, recent findings, and clinical implications.The Psychiatric clinics of North America, 33 1
S. Scarpino, F. d'Alena, A. Napoli, A. Pasquini, A. Marzullo, L. Ruco (2004)
Increased expression of Met protein is associated with up‐regulation of hypoxia inducible factor‐1 (HIF‐1) in tumour cells in papillary carcinoma of the thyroidThe Journal of Pathology, 202
D. Campbell, J. Sutcliffe, P. Ebert, R. Militerni, C. Bravaccio, S. Trillo, M. Elia, C. Schneider, R. Melmed, R. Sacco, A. Persico, P. Levitt (2006)
A genetic variant that disrupts MET transcription is associated with autismProceedings of the National Academy of Sciences, 103
E. Powell, D. Campbell, G. Stanwood, Caleb Davis, J. Noebels, P. Levitt (2003)
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type-Specific Deficits, Epilepsy, and Behavioral DysfunctionThe Journal of Neuroscience, 23
A. Ebens, K. Brose, E. Leonardo, M. Hanson, F. Bladt, C. Birchmeier, B. Barres, M. Tessier-Lavigne (1996)
Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor NeuronsNeuron, 17
J. Rubenstein, M. Merzenich (2003)
Model of autism: increased ratio of excitation/inhibition in key neural systemsGenes, 2
井手 貴雄 (2007)
Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
M. Judson, M. Bergman, D. Campbell, K. Eagleson, P. Levitt (2009)
Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrainJournal of Comparative Neurology, 513
D. Kirchhofer, Xiaoyi Yao, M. Peek, C. Eigenbrot, M. Lipari, K. Billeci, H. Maun, P. Moran, L. Santell, C. Wiesmann, R. Lazarus (2004)
Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor β-Chain in Met Binding and Signaling*Journal of Biological Chemistry, 279
E. Glasson, C. Bower, B. Petterson, N. Klerk, G. Chaney, J. Hallmayer (2004)
Perinatal factors and the development of autism: a population study.Archives of general psychiatry, 61 6
Selma Pennacchietti, P. Michieli, M. Galluzzo, M. Mazzone, S. Giordano, P. Comoglio (2003)
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.Cancer cell, 3 4
P. Levitt, K. Eagleson, E. Powell (2004)
Regulation of neocortical interneuron development and the implications for neurodevelopmental disordersTrends in Neurosciences, 27
L. Lahtinen, Noora Huusko, H. Myöhänen, Anna-Kaisa Lehtivarjo, R. Pellinen, Turunen Mp, S. Ylä-Herttuala, E. Pirinen, A. Pitkänen (2009)
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampusNeuroscience, 163
M. Casanova, D. Buxhoeveden, Juan Gomez (2003)
Disruption in the Inhibitory Architecture of the Cell Minicolumn: Implications for AutisimThe Neuroscientist, 9
B. Thompson, G. Stanwood, P. Levitt (2010)
Specificity of prenatal cocaine exposure effects on cortical interneurons is independent from dopamine D1 receptor co-localizationJournal of Chemical Neuroanatomy, 39
K. Eagleson, A. Bonnin, P. Levitt (2005)
Region‐ and age‐specific deficits in γ‐aminobutyric acidergic neuron development in the telencephalon of the uPAR–/– mouseJournal of Comparative Neurology, 489
Geschwind (2009)
Advances in autismAnnual Review of Medicine, 60
S. Pleasure, S. Anderson, R. Hevner, A. Bagri, O. Marín, D. Lowenstein, J. Rubenstein (2000)
Cell Migration from the Ganglionic Eminences Is Required for the Development of Hippocampal GABAergic InterneuronsNeuron, 28
S. Hara, K. Nakashiro, S. Kłosek, T. Ishikawa, S. Shintani, H. Hamakawa (2006)
Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells.Oral oncology, 42 6
H. Wichterle, J. García-Verdugo, D. Herrera, A. Álvarez-Buylla (1999)
Young neurons from medial ganglionic eminence disperse in adult and embryonic brainNature Neuroscience, 2
L. Naldini, L. Tamagnone, E. Vigna, M. Sachs, G. Hartmann, W. Birchmeier, Daikuhara Yasushi, H. Tsubouchi, F. Blasi, P. Comoglio (1992)
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.The EMBO Journal, 11
F. Blasi (1993)
Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasivenessBioEssays, 15
H. Jyonouchi, L. Geng, Agnès Ruby, B. Zimmerman-Bier (2005)
Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary InterventionNeuropsychobiology, 51
A. Bahi, Frédéric Boyer, T. Kafri, J. Dreyer (2006)
Silencing urokinase in the ventral tegmental area in vivo induces changes in cocaine‐induced hyperlocomotionJournal of Neurochemistry, 98
F. Vaccarino, E. Grigorenko, K. Smith, H. Stevens (2009)
Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for AutismJournal of Autism and Developmental Disorders, 39
D. Campbell, Chun Li, J. Sutcliffe, A. Persico, P. Levitt (2008)
Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorderAutism Research, 1
B. Binder, J. Mihály, G. Prager (2007)
uPAR – uPA – PAI-1 interactions and signaling: A vascular biologist’s viewThrombosis and Haemostasis, 97
K. Shimazaki, Kazunari Yoshida, Yuji Hirose, H. Ishimori, M. Katayama, T. Kawase (2003)
Cytokines regulate c-Met expression in cultured astrocytesBrain Research, 962
D. Campbell, Rosanna D'Oronzio, K. Garbett, P. Ebert, K. Mirnics, P. Levitt, A. Persico (2007)
Disruption of cerebral cortex MET signaling in autism spectrum disorderAnnals of Neurology, 62
D. Geschwind, P. Levitt (2007)
Autism spectrum disorders: developmental disconnection syndromesCurrent Opinion in Neurobiology, 17
P. Giacobini, A. Messina, S. Wray, C. Giampietro, T. Crepaldi, P. Carmeliet, A. Fasolo (2007)
Hepatocyte Growth Factor Acts as a Motogen and Guidance Signal for Gonadotropin Hormone-Releasing Hormone-1 Neuronal MigrationThe Journal of Neuroscience, 27
P. Longati, Alberto Bardelli, C. Ponzetto, Luigi Naldini, P. Comoglio (1994)
Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).Oncogene, 9 1
E. Powell, W. Mars, P. Levitt (2001)
Hepatocyte Growth Factor/Scatter Factor Is a Motogen for Interneurons Migrating from the Ventral to Dorsal TelencephalonNeuron, 30
J. Rubenstein (2010)
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorderCurrent Opinion in Neurology, 23
T. Ide, Y. Kitajima, Atsushi Miyoshi, T. Ohtsuka, Mayumi Mitsuno, Kazuma Ohtaka, K. Miyazaki (2007)
The Hypoxic Environment in Tumor-Stromal Cells Accelerates Pancreatic Cancer Progression via the Activation of Paracrine Hepatocyte Growth Factor/c-Met SignalingAnnals of Surgical Oncology, 14
L. Sussel, O. Marín, S. Kimura, J. Rubenstein (1999)
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.Development, 126 15
Monica Stefan, A. Koch, Annalisa Mancini, A. Mohr, K. Weidner, H. Niemann, T. Tamura (2001)
Src Homology 2-containing Inositol 5-Phosphatase 1 Binds to the Multifunctional Docking Site of c-Met and Potentiates Hepatocyte Growth Factor-induced Branching Tubulogenesis*The Journal of Biological Chemistry, 276
C. Huh, V. Factor, Aránzazu Sánchez, K. Uchida, E. Conner, S. Thorgeirsson (2004)
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.Proceedings of the National Academy of Sciences of the United States of America, 101 13
G. Xiao, M. Jeffers, A. Bellacosa, Y. Mitsuuchi, G. Woude, J. Testa (2001)
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.Proceedings of the National Academy of Sciences of the United States of America, 98 1
Katsuhide Okunishi, M. Dohi, K. Nakagome, R. Tanaka, S. Mizuno, Kunio Matsumoto, J. Miyazaki, Toshikazu Nakamura, K. Yamamoto (2005)
A Novel Role of Hepatocyte Growth Factor as an Immune Regulator through Suppressing Dendritic Cell Function1The Journal of Immunology, 175
H. Larsson, W. Eaton, K. Madsen, M. Vestergaard, A. Olesen, E. Agerbo, D. Schendel, P. Thorsen, P. Mortensen (2005)
Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status.American journal of epidemiology, 161 10
B. Bill, D. Geschwind (2009)
Genetic advances in autism: heterogeneity and convergence on shared pathways.Current opinion in genetics & development, 19 3
W. Mars, R. Zarnegar, G. Michalopoulos (1993)
Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.The American journal of pathology, 143 3
S. Anderson, O. Marín, Carrie Horn, Kelly Jennings, J. Rubenstein (2001)
Distinct cortical migrations from the medial and lateral ganglionic eminences.Development, 128 3
M. Abercrombie (1946)
Estimation of nuclear population from microtome sectionsThe Anatomical Record, 94
E. Powell, Sven Mühlfriedel, J. Bolz, P. Levitt (2003)
Differential Regulation of Thalamic and Cortical Axonal Growth by Hepatocyte Growth Factor/Scatter FactorDevelopmental Neuroscience, 25
C. Ponzetto, A. Bardelli, Z. Zhen, F. Maina, P. Zonca, S. Giordano, A. Graziani, G. Panayotou, P. Comoglio (1994)
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyCell, 77
Maria Valicenti-McDermott, K. McVicar, I. Rapin, B. Wershil, H. Cohen (2006)
Frequency of Gastrointestinal Symptoms in Children with Autistic Spectrum Disorders and Association with Family History of Autoimmune DiseaseJournal of Developmental & Behavioral Pediatrics, 27
G. Martins, C. Plachez, E. Powell (2006)
Loss of Embryonic MET Signaling Alters Profiles of Hippocampal InterneuronsDevelopmental Neuroscience, 29
Pat Levitt, D. Campbell (2009)
The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders.The Journal of clinical investigation, 119 4
F. Koga, S. Tsutsumi, L. Neckers (2007)
Low Dose Geldanamycin Inhibits Hepatocyte Growth Factor- and Hypoxia-Stimulated Invasion of Cancer CellsCell Cycle, 6
S. Anderson, D. Eisenstat, Leyuan Shi, J. Rubenstein (1997)
Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.Science, 278 5337
Z.Josh Huang, A. Kirkwood, T. Pizzorusso, V. Porciatti, B. Morales, M. Bear, L. Maffei, S. Tonegawa (1999)
BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual CortexCell, 98
(2006)
Cerebral Cortex doi:10.1093/cercor/bhl006 Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum
C. Marshall, A. Noor, J. Vincent, A. Lionel, L. Feuk, J. Skaug, M. Shago, R. Moessner, D. Pinto, Yan Ren, Bhooma Thiruvahindrapduram, A. Fiebig, S. Schreiber, J. Friedman, Cees Ketelaars, Y. Vos, C. Ficicioglu, S. Kirkpatrick, R. Nicolson, L. Sloman, A. Summers, Clare Gibbons, A. Teebi, D. Chitayat, R. Weksberg, A. Thompson, C. Vardy, Victoria Crosbie, S. Luscombe, Rebecca Baatjes, L. Zwaigenbaum, W. Roberts, B. Fernandez, P. Szatmari, S. Scherer (2008)
Structural variation of chromosomes in autism spectrum disorder.American journal of human genetics, 82 2
T. Masos, R. Miskin (1996)
Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain.Brain research. Molecular brain research, 35 1-2
Y. Uehara, O. Minowa, C. Mori, K. Shiota, J. Kuno, T. Noda, N. Kitamura (1995)
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factorNature, 373
Candidate risk genes for autism spectrum disorder (ASD) have been identified, but the challenge of determining their contribution to pathogenesis remains. We previously identified two ASD risk genes encoding the receptor tyrosine kinase MET and the urokinase plasminogen activator receptor (PLAUR), which is thought to modulate availability of the MET ligand. We also reported a role for Met signaling in cortical interneuron development in vitro and a reduction of these neurons in uPAR (mouse ortholog of PLAUR) null mice, suggesting that disruption of either gene impacts cortical development similarly. Here, we modify this conclusion, reporting that interneuron numbers are unchanged in the neocortex of Metfx/fx/ Dlx5/6cre mice, in which Met is ablated from cells arising from the ventral telencephalon (VTel). Consistent with this, Met transcript is not detected in the VTel during interneuron genesis and migration; furthermore, during the postnatal period of interneuron maturation, Met is co‐expressed in glutamatergic projection neurons, but not interneurons. Low levels of Met protein are expressed in the VTel at E12.5 and E14.5, likely reflecting the arrival of Met containing corticofugal axons. Met expression, however, is induced in E12.5 VTel cells after 2 days in vitro, perhaps underlying discrepancies between observations in vitro and in Metfx/fx/ Dlx5/6cre mice. We suggest that, in vivo, Met impacts the development of cortical projection neurons, whereas uPAR influences interneuron maturation. An altered balance between excitation and inhibition has been postulated as a biological mechanism for ASD; this imbalance could arise from different risk genes differentially affecting either or both elements.
Autism Research – Wiley
Published: Feb 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.