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SUMMARY The associations of satellited chromosomes with other chromosomes have been determined in photomicrographs of 423 human somatic cells in mitosis. It is found that the frequency with which a satellited chromosome lies in juxtaposition to a particular chromosome is not purely a function of the length of that chromosome (as might be expected if the assumption were true that satellited chromosomes are distributed at random throughout the cell.) The non‐random distribution of satellited chromosomes uncovered by the study is attributed to associations at specific chromosome regions. The most common association was the well‐known and often multiple one occurring between the short arms of satellited chromosomes. A relatively high frequency of associations also occurred between the short arms of satellited chromosomes and specific non‐satellited regions of chromosomes 2, 6, 18, 19, 21 and/or 22. Much less frequent associations occurred also with specific regions of chromosomes 1, 3 and 17. A feature common to all significant associations is that they tend to occur close to sites where secondary constrictions have been demonstrated. This finding suggests that these associations may indicate the position of active nucleolus‐organizer sites. It is also postulated that chromosome associations are the result of nucleolus fusion during interphase. Evidence from organisms other than man is presented in support of the hypothesis that a tendency to chromosome association between ‘nucleolar chromosomes’ may be a general phenomenon. The possible implications of chromosome association with respect to the aetiology of human chromosomal aberrations is discussed. The writers are grateful to Dr James H. Renwick for suggestions on the presentation of the data, and to Marie E. Ferguson‐Smith for preparing the figures. This investigation was supported in part by Research Grant 7841 from the Division of General Medical Sciences, the United States Public Health Service.
Annals of Human Genetics – Wiley
Published: Nov 1, 1963
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