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The association of HLA‐linked genes with systemic lupus erythematosus

The association of HLA‐linked genes with systemic lupus erythematosus SUMMARY The reported associations between HLA antigen DR3 and null (QO) alleles at the C4A and C4B loci and systemic lupus erythematosus are here analysed. The empirical logistic method has been applied to a body of data which included the relevant genotypes. The analysis suggests that the association with null alleles at the C4 loci is primary and the DR3 association is likely to be secondary to this. This may give information as to the location of the HLA‐linked disease susceptibility gene. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

The association of HLA‐linked genes with systemic lupus erythematosus

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References (9)

Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1986.tb01942.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY The reported associations between HLA antigen DR3 and null (QO) alleles at the C4A and C4B loci and systemic lupus erythematosus are here analysed. The empirical logistic method has been applied to a body of data which included the relevant genotypes. The analysis suggests that the association with null alleles at the C4 loci is primary and the DR3 association is likely to be secondary to this. This may give information as to the location of the HLA‐linked disease susceptibility gene.

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1986

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